Nek1 (NIMA related kinase 1) - Rat Genome Database

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Gene: Nek1 (NIMA related kinase 1) Heterocephalus glaber
Analyze
Symbol: Nek1
Name: NIMA related kinase 1
RGD ID: 18931002
Description: ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); INVOLVED IN DNA damage response (ortholog); kidney development (ortholog); multicellular organism growth (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); amyotrophic lateral sclerosis type 24 (ortholog); asphyxiating thoracic dystrophy (ortholog); FOUND IN centriolar satellite (inferred); centrosome (inferred); cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase Nek1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624769945,644 - 1,147,246 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624769945,788 - 1,146,921 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Nek1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624769945,644 - 1,147,246 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624769945,788 - 1,146,921 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
NEK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384169,392,809 - 169,612,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4169,369,704 - 169,612,632 (-)EnsemblGRCh38hg38GRCh38
GRCh374170,313,960 - 170,533,734 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364170,551,004 - 170,770,189 (-)NCBINCBI36Build 36hg18NCBI36
Build 344170,689,158 - 170,908,344NCBI
Celera4167,647,120 - 167,866,584 (-)NCBICelera
Cytogenetic Map4q33NCBI
HuRef4166,069,151 - 166,288,552 (-)NCBIHuRef
CHM1_14170,290,871 - 170,510,372 (-)NCBICHM1_1
T2T-CHM13v2.04172,752,512 - 172,972,332 (-)NCBIT2T-CHM13v2.0
Nek1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39861,446,184 - 61,584,383 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl861,446,229 - 61,584,380 (+)EnsemblGRCm39 Ensembl
GRCm38860,993,157 - 61,131,349 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl860,993,195 - 61,131,346 (+)EnsemblGRCm38mm10GRCm38
MGSCv37863,472,017 - 63,609,031 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36863,885,335 - 64,023,496 (+)NCBIMGSCv36mm8
Celera863,560,390 - 63,696,381 (+)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map830.91NCBI
Nek1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81634,009,092 - 34,137,418 (-)NCBIGRCr8
mRatBN7.21628,998,229 - 29,125,426 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1628,998,231 - 29,117,723 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1632,593,117 - 32,712,602 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01636,026,844 - 36,146,328 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01632,228,326 - 32,347,844 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01632,321,010 - 32,439,421 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1632,321,010 - 32,439,421 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01632,155,914 - 32,274,325 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01631,025,718 - 31,032,968 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41632,317,987 - 32,438,010 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11632,320,904 - 32,431,386 (-)NCBI
Celera1628,993,115 - 29,112,552 (-)NCBICelera
Cytogenetic Map16p12NCBI
Nek1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540336,720,162 - 36,881,891 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540336,710,248 - 36,878,901 (+)NCBIChiLan1.0ChiLan1.0
NEK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23167,174,897 - 167,388,951 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14167,530,541 - 167,744,594 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04161,618,181 - 161,830,332 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14173,690,074 - 173,902,100 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4173,690,074 - 173,902,100 (-)Ensemblpanpan1.1panPan2
NEK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12520,297,190 - 20,528,537 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2520,299,079 - 20,518,483 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2520,934,647 - 21,153,217 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02520,475,506 - 20,704,356 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2520,475,503 - 20,694,127 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12520,318,819 - 20,578,371 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02520,295,186 - 20,524,672 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02520,394,714 - 20,624,101 (-)NCBIUU_Cfam_GSD_1.0
Nek1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494321,094,565 - 21,252,579 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365161,508,811 - 1,666,869 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365161,508,800 - 1,666,841 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1420,144,659 - 20,332,245 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11420,144,631 - 20,332,248 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21421,439,141 - 21,626,347 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17115,621,917 - 115,819,349 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7115,621,916 - 115,819,291 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603795,560,952 - 95,765,438 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000017646   ⟹   ENSHGLP00000017472
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624769945,644 - 1,147,246 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000017647   ⟹   ENSHGLP00000017473
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624769945,644 - 1,147,246 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000017648   ⟹   ENSHGLP00000017474
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624769946,896 - 1,137,150 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000017649   ⟹   ENSHGLP00000017475
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624769946,896 - 1,137,150 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000017650   ⟹   ENSHGLP00000017476
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624769946,896 - 1,137,150 (-)Ensembl
RefSeq Acc Id: XM_021264927   ⟹   XP_021120586
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624769945,788 - 1,146,920 (-)NCBI
RefSeq Acc Id: XM_021264928   ⟹   XP_021120587
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624769945,788 - 1,146,920 (-)NCBI
RefSeq Acc Id: XM_021264929   ⟹   XP_021120588
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624769945,788 - 1,146,920 (-)NCBI
RefSeq Acc Id: XM_021264930   ⟹   XP_021120589
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624769945,788 - 1,146,921 (-)NCBI
RefSeq Acc Id: XM_021264931   ⟹   XP_021120590
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624769945,788 - 1,146,920 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_021120589   ⟸   XM_021264930
- Peptide Label: isoform X4
- UniProtKB: G5BC21 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021120590   ⟸   XM_021264931
- Peptide Label: isoform X5
- UniProtKB: G5BC21 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021120588   ⟸   XM_021264929
- Peptide Label: isoform X3
- UniProtKB: G5BC21 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021120587   ⟸   XM_021264928
- Peptide Label: isoform X2
- UniProtKB: G5BC21 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021120586   ⟸   XM_021264927
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JEN4 (UniProtKB/TrEMBL),   G5BC21 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000017473   ⟸   ENSHGLT00000017647
RefSeq Acc Id: ENSHGLP00000017475   ⟸   ENSHGLT00000017649
RefSeq Acc Id: ENSHGLP00000017472   ⟸   ENSHGLT00000017646
RefSeq Acc Id: ENSHGLP00000017474   ⟸   ENSHGLT00000017648
RefSeq Acc Id: ENSHGLP00000017476   ⟸   ENSHGLT00000017650


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000012517 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000017647 ENTREZGENE
  ENSHGLT00000017648 ENTREZGENE
  ENSHGLT00000017649 ENTREZGENE
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Nek1 ENTREZGENE
PANTHER CAMK FAMILY PROTEIN KINASE UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE NEK1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0P6JEN4 ENTREZGENE, UniProtKB/TrEMBL
  G5BC21 ENTREZGENE, UniProtKB/TrEMBL