Slc25a5 (solute carrier family 25 member 5)

Gene: Slc25a5 (solute carrier family 25 member 5) Heterocephalus glaber

Analyze

Symbol:

Slc25a5

Name:

solute carrier family 25 member 5

RGD ID:

18929797

Description:

ENCODES a protein that exhibits adenine nucleotide transmembrane transporter activity (inferred); ATP:ADP antiporter activity (inferred); oxidative phosphorylation uncoupler activity (inferred); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); ASSOCIATED WITH autistic disorder (ortholog); syndromic X-linked intellectual disability Cabezas type (ortholog); syndromic X-linked intellectual disability Lubs type (ortholog); FOUND IN membrane raft (ortholog); mitochondrial inner membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ADP/ATP translocase 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624895	3,472,791 - 3,477,568 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624895	3,472,810 - 3,475,713 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

syndromic X-linked intellectual disability Cabezas type (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adaptive thermogenesis (IEA)

adenine nucleotide transport (IEA)

B cell differentiation (IEA)

cellular response to leukemia inhibitory factor (IEA,ISO)

chromosome segregation (IEA)

erythrocyte differentiation (IEA)

mitochondrial ADP transmembrane transport (IEA)

mitochondrial ATP transmembrane transport (IEA)

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (IEA)

positive regulation of cell population proliferation (IEA)

positive regulation of mitophagy (IEA)

proton transmembrane transport (IEA)

regulation of mitochondrial membrane permeability (IEA)

Cellular Component

membrane (IEA)

membrane raft (ISO)

mitochondrial envelope (IEA)

mitochondrial inner membrane (IEA,ISO)

mitochondrial nucleoid (IEA)

mitochondrial permeability transition pore complex (IEA)

mitochondrion (IEA)

MMXD complex (IEA)

Molecular Function

adenine nucleotide transmembrane transporter activity (IEA)

ATP:ADP antiporter activity (IEA)

oxidative phosphorylation uncoupler activity (IEA)

protein binding (ISO)

proton transmembrane transporter activity (IEA)

ubiquitin protein ligase binding (IEA)

References

Additional References at PubMed

PMID:21993625	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Slc25a5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624895	3,472,791 - 3,477,568 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624895	3,472,810 - 3,475,713 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

SLC25A5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	119,468,444 - 119,471,396 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	119,468,422 - 119,471,396 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	118,602,407 - 118,605,359 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	118,486,433 - 118,489,320 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	118,384,290 - 118,387,161	NCBI
Celera	X	119,057,070 - 119,060,067 (+)	NCBI		Celera
Cytogenetic Map	X	q24	NCBI
HuRef	X	108,095,551 - 108,098,548 (+)	NCBI		HuRef
CHM1_1	X	118,513,525 - 118,516,522 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	117,846,144 - 117,849,097 (+)	NCBI		T2T-CHM13v2.0

Slc25a5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	36,059,250 - 36,062,461 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	36,059,304 - 36,062,460 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	36,795,597 - 36,798,808 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	36,795,651 - 36,798,807 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	34,335,647 - 34,338,801 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	33,227,097 - 33,230,251 (+)	NCBI		MGSCv36	mm8
Celera	X	23,519,362 - 23,522,516 (+)	NCBI		Celera
Cytogenetic Map	X	A3.3	NCBI
cM Map	X	21.2	NCBI

Slc25a5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	120,897,616 - 120,900,683 (+)	NCBI		GRCr8
mRatBN7.2	X	116,031,896 - 116,034,963 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	116,031,803 - 116,034,967 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	118,134,175 - 118,137,242 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	121,703,302 - 121,706,369 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	119,249,467 - 119,252,534 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	123,404,570 - 123,407,637 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	123,404,518 - 123,407,645 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	123,549,736 - 123,552,803 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	8,072,239 - 8,075,306 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	8,077,794 - 8,080,862 (-)	NCBI
Celera	X	115,261,785 - 115,264,852 (+)	NCBI		Celera
Cytogenetic Map	X	q34	NCBI

Slc25a5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955534	496,933 - 510,934 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955534	497,518 - 500,309 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC25A5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	118,849,815 - 118,852,908 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	118,853,555 - 118,856,512 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	108,501,654 - 108,504,591 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	118,926,743 - 118,929,632 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	118,926,743 - 118,929,624 (+)	Ensembl	panpan1.1		panPan2

SLC25A5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	91,523,649 - 91,526,447 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	91,523,643 - 91,526,479 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	77,598,424 - 77,601,277 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	93,263,040 - 93,265,893 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	X	90,715,875 - 90,718,728 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	92,474,556 - 92,477,406 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	92,203,556 - 92,206,409 (+)	NCBI		UU_Cfam_GSD_1.0

Slc25a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	90,552,351 - 90,555,323 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936479	10,432,172 - 10,435,154 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC25A5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	97,919,290 - 97,922,239 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	97,919,295 - 97,922,245 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	113,743,301 - 113,746,201 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103247334
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666065	32,209,084 - 32,212,570 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_004872156	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01100865	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JH171897	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSHGLT00000020779 ⟹ ENSHGLP00000020577

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624895	3,472,791 - 3,477,568 (+)	Ensembl

RefSeq Acc Id:

XM_004872156 ⟹ XP_004872213

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624895	3,472,810 - 3,475,713 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_004872213	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EHB12828	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000020577
	ENSHGLP00000043222
	ENSHGLP00100045001

RefSeq Acc Id:	XP_004872213 ⟸ XM_004872156
- UniProtKB:	G5BU67 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSHGLP00000020577 ⟸ ENSHGLT00000020779

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000000244	UniProtKB/TrEMBL
	ENSHGLG00000014712	Ensembl, ENTREZGENE
	ENSHGLG00100051896	UniProtKB/TrEMBL
Ensembl Transcript	ENSHGLT00000020779	ENTREZGENE
	ENSHGLT00000066402	UniProtKB/TrEMBL
	ENSHGLT00100085233	UniProtKB/TrEMBL
Gene3D-CATH	1.50.40.10	UniProtKB/TrEMBL
InterPro	ADT_euk_type	UniProtKB/TrEMBL
	Mit_carrier	UniProtKB/TrEMBL
	Mitochondrial_sb/sol_carrier	UniProtKB/TrEMBL
	Mt_carrier_dom_sf	UniProtKB/TrEMBL
KEGG Report	hgl:101697130	UniProtKB/TrEMBL
NCBI Gene	Slc25a5	ENTREZGENE
PANTHER	ADP/ATP TRANSLOCASE 2	UniProtKB/TrEMBL
	PTHR45635	UniProtKB/TrEMBL
Pfam	Mito_carr	UniProtKB/TrEMBL
PRINTS	ADPTRNSLCASE	UniProtKB/TrEMBL
	MITOCARRIER	UniProtKB/TrEMBL
PROSITE	SOLCAR	UniProtKB/TrEMBL
Superfamily-SCOP	SSF103506	UniProtKB/TrEMBL
UniProt	G5BU67	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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