Mcmdc2 (minichromosome maintenance domain containing 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Mcmdc2 (minichromosome maintenance domain containing 2) Heterocephalus glaber
Analyze
Symbol: Mcmdc2
Name: minichromosome maintenance domain containing 2
RGD ID: 18928638
Description: ENCODES a protein that exhibits ATP binding (inferred); DNA binding (inferred); single-stranded DNA helicase activity (inferred); INVOLVED IN double-strand break repair involved in meiotic recombination (ortholog); late meiotic recombination nodule assembly (ortholog); meiotic recombination nodule assembly (ortholog); ASSOCIATED WITH azoospermia (ortholog); Joubert syndrome 21 (ortholog); spermatogenic failure 57 (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: MCM domain-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474424,425,515 - 24,471,470 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474424,422,656 - 24,483,365 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mcmdc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474424,425,515 - 24,471,470 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474424,422,656 - 24,483,365 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MCMDC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38866,870,771 - 66,926,382 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl866,870,749 - 66,922,048 (+)EnsemblGRCh38hg38GRCh38
GRCh37867,783,006 - 67,834,283 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36867,948,884 - 67,976,570 (+)NCBINCBI36Build 36hg18NCBI36
Celera863,776,478 - 63,827,777 (+)NCBICelera
Cytogenetic Map8q13.1NCBI
HuRef863,275,571 - 63,326,869 (+)NCBIHuRef
CHM1_1867,837,961 - 67,889,304 (+)NCBICHM1_1
T2T-CHM13v2.0867,297,252 - 67,352,914 (+)NCBIT2T-CHM13v2.0
Mcmdc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3919,978,863 - 10,011,179 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl19,978,863 - 10,012,310 (+)EnsemblGRCm39 Ensembl
GRCm3819,906,157 - 9,943,606 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl19,908,638 - 9,942,085 (+)EnsemblGRCm38mm10GRCm38
MGSCv3719,898,719 - 9,931,035 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3619,896,933 - 9,926,168 (+)NCBIMGSCv36mm8
Celera19,881,469 - 9,914,977 (+)NCBICelera
Cytogenetic Map1A2NCBI
cM Map12.19NCBI
Mcmdc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8514,071,609 - 14,120,435 (-)NCBIGRCr8
mRatBN7.259,291,967 - 9,337,526 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl59,298,101 - 9,338,300 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx511,454,559 - 11,494,044 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0513,084,457 - 13,123,993 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0512,789,227 - 12,828,713 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.058,973,861 - 9,039,616 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl58,978,010 - 9,038,594 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0513,781,014 - 13,839,762 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.458,842,432 - 8,881,827 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera58,810,709 - 8,849,895 (-)NCBICelera
Cytogenetic Map5q11NCBI
Mcmdc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544412,348,543 - 12,382,769 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544412,348,537 - 12,382,769 (-)NCBIChiLan1.0ChiLan1.0
MCMDC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2782,606,924 - 82,685,993 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1858,249,270 - 58,328,279 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0863,412,462 - 63,465,258 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1865,079,264 - 65,128,147 (+)NCBIpanpan1.1PanPan1.1panPan2
MCMDC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12916,424,088 - 16,462,094 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2916,426,318 - 16,460,599 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2916,739,713 - 16,777,699 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02916,504,173 - 16,542,352 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2916,503,756 - 16,540,857 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12916,536,436 - 16,574,575 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02916,636,010 - 16,674,434 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02916,892,562 - 16,930,779 (+)NCBIUU_Cfam_GSD_1.0
Mcmdc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530367,602,488 - 67,607,766 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364967,149,501 - 7,182,771 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCMDC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl467,847,817 - 67,895,867 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1467,850,585 - 67,892,438 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2473,908,711 - 73,952,722 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MCMDC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1862,742,176 - 62,790,994 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl862,745,855 - 62,790,143 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603978,709,912 - 78,763,056 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000017964   ⟹   ENSHGLP00000017788
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474424,425,515 - 24,471,470 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000017965   ⟹   ENSHGLP00000017789
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474424,425,817 - 24,471,376 (-)Ensembl
RefSeq Acc Id: XM_004842094   ⟹   XP_004842151
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474424,422,656 - 24,475,393 (-)NCBI
RefSeq Acc Id: XM_021256060   ⟹   XP_021111719
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474424,422,656 - 24,475,393 (-)NCBI
RefSeq Acc Id: XM_021256061   ⟹   XP_021111720
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474424,422,656 - 24,483,365 (-)NCBI
RefSeq Acc Id: XM_021256062   ⟹   XP_021111721
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474424,422,656 - 24,475,393 (-)NCBI
RefSeq Acc Id: XM_021256063   ⟹   XP_021111722
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474424,422,656 - 24,475,393 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_021111720   ⟸   XM_021256061
- Peptide Label: isoform X1
- UniProtKB: G5AQN3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021111719   ⟸   XM_021256060
- Peptide Label: isoform X1
- UniProtKB: G5AQN3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021111722   ⟸   XM_021256063
- Peptide Label: isoform X3
RefSeq Acc Id: XP_021111721   ⟸   XM_021256062
- Peptide Label: isoform X2
RefSeq Acc Id: XP_004842151   ⟸   XM_004842094
- Peptide Label: isoform X1
- UniProtKB: G5AQN3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000017788   ⟸   ENSHGLT00000017964
RefSeq Acc Id: ENSHGLP00000017789   ⟸   ENSHGLT00000017965


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000012730 Ensembl, ENTREZGENE
  ENSHGLG00100011553 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000017964 ENTREZGENE
  ENSHGLT00100015819 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro MCM UniProtKB/TrEMBL
  MCM_lid UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report hgl:101711255 UniProtKB/TrEMBL
NCBI Gene Mcmdc2 ENTREZGENE
PANTHER MINICHROMOSOME MAINTENANCE DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
  PTHR11630 UniProtKB/TrEMBL
Pfam MCM_lid UniProtKB/TrEMBL
SMART MCM UniProtKB/TrEMBL
UniProt G5AQN3 ENTREZGENE, UniProtKB/TrEMBL