Sptlc3 (serine palmitoyltransferase long chain base subunit 3) - Rat Genome Database

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Gene: Sptlc3 (serine palmitoyltransferase long chain base subunit 3) Heterocephalus glaber
Analyze
Symbol: Sptlc3
Name: serine palmitoyltransferase long chain base subunit 3
RGD ID: 18925214
Description: ENCODES a protein that exhibits acyltransferase activity (inferred); pyridoxal phosphate binding (inferred); serine C-palmitoyltransferase activity (inferred); INVOLVED IN sphingoid biosynthetic process (ortholog); ASSOCIATED WITH sensory peripheral neuropathy (ortholog); FOUND IN serine C-palmitoyltransferase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine palmitoyltransferase 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474113,956,570 - 14,152,600 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474113,956,688 - 14,152,127 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Sptlc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474113,956,570 - 14,152,600 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474113,956,688 - 14,152,127 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SPTLC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382013,008,972 - 13,169,103 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2013,008,972 - 13,169,103 (+)EnsemblGRCh38hg38GRCh38
GRCh372012,989,620 - 13,149,750 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362012,937,627 - 13,095,411 (+)NCBINCBI36Build 36hg18NCBI36
Celera2013,059,733 - 13,217,481 (+)NCBICelera
Cytogenetic Map20p12.1NCBI
HuRef2012,941,029 - 13,101,523 (+)NCBIHuRef
CHM1_12012,989,665 - 13,147,485 (+)NCBICHM1_1
T2T-CHM13v2.02013,048,743 - 13,212,449 (+)NCBIT2T-CHM13v2.0
Sptlc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392139,335,833 - 139,478,981 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2139,335,833 - 139,479,594 (+)EnsemblGRCm39 Ensembl
GRCm382139,493,913 - 139,637,061 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2139,493,913 - 139,637,674 (+)EnsemblGRCm38mm10GRCm38
MGSCv372139,319,656 - 139,463,410 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362139,185,361 - 139,329,115 (+)NCBIMGSCv36mm8
Celera2140,671,316 - 140,814,560 (+)NCBICelera
Cytogenetic Map2F3NCBI
cM Map268.52NCBI
Sptlc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83147,301,570 - 147,431,696 (+)NCBIGRCr8
mRatBN7.23126,847,878 - 126,978,010 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3126,847,878 - 126,978,010 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3130,707,371 - 130,835,985 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03139,291,458 - 139,420,089 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03136,994,594 - 137,123,206 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03132,560,437 - 132,689,313 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3132,560,506 - 132,692,737 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03139,023,075 - 139,151,792 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43127,691,668 - 127,825,206 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13127,597,526 - 127,729,920 (+)NCBI
Celera3125,501,233 - 125,630,510 (+)NCBICelera
Cytogenetic Map3q36NCBI
Sptlc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541522,531,626 - 22,682,564 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541522,532,193 - 22,686,071 (+)NCBIChiLan1.0ChiLan1.0
SPTLC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22113,894,378 - 14,053,615 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12013,891,210 - 14,052,725 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02012,966,584 - 13,125,802 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12012,952,501 - 13,111,347 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2012,952,524 - 13,111,347 (+)Ensemblpanpan1.1panPan2
SPTLC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1249,447,575 - 9,597,544 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl249,447,859 - 9,595,975 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha249,258,320 - 9,409,355 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0249,860,196 - 10,010,807 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl249,861,421 - 10,011,073 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1249,471,327 - 9,619,877 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0249,555,159 - 9,706,174 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0249,904,468 - 10,055,517 (-)NCBIUU_Cfam_GSD_1.0
Sptlc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640158,213,063 - 158,353,439 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364856,644,188 - 6,784,828 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364856,647,930 - 6,784,792 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPTLC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1721,769,484 - 21,903,264 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11721,769,388 - 21,903,269 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21724,339,933 - 24,473,785 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPTLC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,900,389 - 42,067,842 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,900,447 - 42,070,112 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660542,190,751 - 2,332,203 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004840827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021255072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021255073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021255074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01019252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01019265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSHGLT00000022593   ⟹   ENSHGLP00000022382
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474113,956,570 - 14,152,600 (+)Ensembl
RefSeq Acc Id: XM_004840827   ⟹   XP_004840884
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474113,956,688 - 14,152,127 (+)NCBI
RefSeq Acc Id: XM_021255072   ⟹   XP_021110731
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474113,956,688 - 14,152,127 (+)NCBI
RefSeq Acc Id: XM_021255073   ⟹   XP_021110732
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474113,956,688 - 14,152,127 (+)NCBI
RefSeq Acc Id: XM_021255074   ⟹   XP_021110733
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474113,956,688 - 14,152,127 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004840884 (Get FASTA)   NCBI Sequence Viewer  
  XP_021110731 (Get FASTA)   NCBI Sequence Viewer  
  XP_021110732 (Get FASTA)   NCBI Sequence Viewer  
  XP_021110733 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000022382
Reference Protein Sequences
RefSeq Acc Id: XP_004840884   ⟸   XM_004840827
- Peptide Label: isoform X1
- UniProtKB: G5ALV7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021110731   ⟸   XM_021255072
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021110732   ⟸   XM_021255073
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021110733   ⟸   XM_021255074
- Peptide Label: isoform X2
RefSeq Acc Id: ENSHGLP00000022382   ⟸   ENSHGLT00000022593


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000015963 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000022593 ENTREZGENE
Gene3D-CATH Aspartate Aminotransferase, domain 1 UniProtKB/TrEMBL
  Type I PLP-dependent aspartate aminotransferase-like (Major domain) UniProtKB/TrEMBL
InterPro Aminotrans_II_pyridoxalP_BS UniProtKB/TrEMBL
  Aminotransferase_I/II UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_small UniProtKB/TrEMBL
NCBI Gene Sptlc3 ENTREZGENE
PANTHER CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE UniProtKB/TrEMBL
  SERINE PALMITOYLTRANSFERASE 3 UniProtKB/TrEMBL
Pfam Aminotran_1_2 UniProtKB/TrEMBL
PROSITE AA_TRANSFER_CLASS_2 UniProtKB/TrEMBL
Superfamily-SCOP PLP-dependent transferases UniProtKB/TrEMBL
UniProt G5ALV7 ENTREZGENE, UniProtKB/TrEMBL