Mre11 (MRE11 homolog, double strand break repair nuclease) - Rat Genome Database

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Gene: Mre11 (MRE11 homolog, double strand break repair nuclease) Heterocephalus glaber
Analyze
Symbol: Mre11
Name: MRE11 homolog, double strand break repair nuclease
RGD ID: 18914734
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA helicase activity (ortholog); INVOLVED IN cell population proliferation (ortholog); chromosome organization (ortholog); DNA damage response (ortholog); PARTICIPATES IN altered p53 signaling pathway; ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; ASSOCIATED WITH Alzheimer's disease (ortholog); Animal Disease Models (ortholog); ataxia telangiectasia (ortholog); FOUND IN BRCA1-C complex (ortholog); chromatin (ortholog); condensed nuclear chromosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: double-strand break repair protein MRE11; double-strand break repair protein MRE11A; MRE11 homolog A, double strand break repair nuclease; Mre11a
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473539,092,781 - 39,153,920 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473539,095,559 - 39,153,936 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mre11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473539,092,781 - 39,153,920 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473539,095,559 - 39,153,936 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MRE11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381194,415,570 - 94,512,412 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1194,415,570 - 94,493,885 (-)EnsemblGRCh38hg38GRCh38
GRCh371194,148,736 - 94,227,010 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361193,790,114 - 93,866,688 (-)NCBINCBI36Build 36hg18NCBI36
Build 341193,790,120 - 93,866,688NCBI
Celera1191,438,299 - 91,514,850 (-)NCBICelera
Cytogenetic Map11q21NCBI
HuRef1190,216,033 - 90,292,535 (-)NCBIHuRef
CHM1_11194,033,481 - 94,110,055 (-)NCBICHM1_1
T2T-CHM13v2.01194,422,612 - 94,519,751 (-)NCBIT2T-CHM13v2.0
Mre11a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39914,695,971 - 14,748,421 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl914,695,950 - 14,748,419 (+)EnsemblGRCm39 Ensembl
GRCm38914,784,654 - 14,837,125 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl914,784,654 - 14,837,123 (+)EnsemblGRCm38mm10GRCm38
MGSCv37914,589,151 - 14,638,861 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36914,535,100 - 14,584,812 (+)NCBIMGSCv36mm8
Celera912,065,444 - 12,115,180 (+)NCBICelera
Cytogenetic Map9A2NCBI
cM Map94.33NCBI
Mre11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8819,900,211 - 19,961,906 (+)NCBIGRCr8
mRatBN7.2811,618,876 - 11,680,451 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl811,632,354 - 11,678,279 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx815,618,017 - 15,661,868 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0813,915,762 - 13,959,614 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0811,891,307 - 11,935,517 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0813,304,355 - 13,350,329 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl813,305,152 - 13,352,489 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0813,244,991 - 13,290,976 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4811,588,409 - 11,632,483 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1811,588,411 - 11,632,483 (+)NCBI
Celera813,102,879 - 13,146,939 (+)NCBICelera
Cytogenetic Map8q12NCBI
MRE11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2995,258,930 - 95,341,115 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11196,350,676 - 96,432,591 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01189,418,537 - 89,500,705 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11192,908,403 - 92,985,966 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1192,918,549 - 92,985,966 (-)Ensemblpanpan1.1panPan2
MRE11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1216,448,909 - 6,528,185 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl216,449,822 - 6,527,119 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha216,459,592 - 6,538,889 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0216,629,575 - 6,708,953 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl216,630,485 - 6,708,909 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1216,416,396 - 6,489,663 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0216,479,470 - 6,558,763 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0216,528,550 - 6,608,693 (+)NCBIUU_Cfam_GSD_1.0
Mre11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494779,363,444 - 79,439,016 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936674466,456 - 530,317 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936674466,495 - 528,072 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRE11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl926,572,361 - 26,634,567 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1926,572,352 - 26,634,596 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2930,330,565 - 30,388,455 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MRE11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1185,615,448 - 85,694,247 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl185,610,819 - 85,694,269 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604340,060,929 - 40,162,758 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000022291   ⟹   ENSHGLP00000022080
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473539,092,781 - 39,153,920 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000022292   ⟹   ENSHGLP00000022081
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473539,095,691 - 39,152,930 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000022293   ⟹   ENSHGLP00000022082
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473539,095,691 - 39,152,930 (-)Ensembl
RefSeq Acc Id: XM_004838047   ⟹   XP_004838104
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473539,095,559 - 39,153,936 (-)NCBI
RefSeq Acc Id: XM_013069640   ⟹   XP_012925094
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473539,095,559 - 39,153,936 (-)NCBI
RefSeq Acc Id: XM_021252663   ⟹   XP_021108322
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473539,095,559 - 39,153,895 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004838104 (Get FASTA)   NCBI Sequence Viewer  
  XP_012925094 (Get FASTA)   NCBI Sequence Viewer  
  XP_021108322 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000022081
  ENSHGLP00100001994
GenBank Protein JAN96928 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_012925094   ⟸   XM_013069640
- Peptide Label: isoform X2
- UniProtKB: G5BCY4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004838104   ⟸   XM_004838047
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J995 (UniProtKB/TrEMBL),   G5BCY4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021108322   ⟸   XM_021252663
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J995 (UniProtKB/TrEMBL),   G5BCY4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000022080   ⟸   ENSHGLT00000022291
RefSeq Acc Id: ENSHGLP00000022082   ⟸   ENSHGLT00000022293
RefSeq Acc Id: ENSHGLP00000022081   ⟸   ENSHGLT00000022292


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000015754 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLG00100001555 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000022292 ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLT00100002039 UniProtKB/TrEMBL
Gene3D-CATH 3.30.110.110 UniProtKB/TrEMBL
  3.60.21.10 UniProtKB/TrEMBL
InterPro Calcineurin-like_PHP_ApaH UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/TrEMBL
  Mre11 UniProtKB/TrEMBL
  Mre11_capping_dom UniProtKB/TrEMBL
  Mre11_DNA-bd UniProtKB/TrEMBL
  Mre11_N UniProtKB/TrEMBL
KEGG Report hgl:101709211 UniProtKB/TrEMBL
NCBI Gene Mre11 ENTREZGENE
PANTHER DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11 UniProtKB/TrEMBL
  DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11 UniProtKB/TrEMBL
Pfam Metallophos UniProtKB/TrEMBL
  Mre11_DNA_bind UniProtKB/TrEMBL
PIRSF DSB_repair_MRE11 UniProtKB/TrEMBL
SMART Mre11_DNA_bind UniProtKB/TrEMBL
Superfamily-SCOP SSF56300 UniProtKB/TrEMBL
UniProt A0A0P6J995 ENTREZGENE, UniProtKB/TrEMBL
  G5BCY4 ENTREZGENE, UniProtKB/TrEMBL