RGD Reference Report - Deficiency of the Mre11 DNA repair complex in Alzheimer's disease brains. - Rat Genome Database

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Deficiency of the Mre11 DNA repair complex in Alzheimer's disease brains.

Authors: Jacobsen, E  Beach, T  Shen, Y  Li, R  Chang, Y 
Citation: Jacobsen E, etal., Brain Res Mol Brain Res. 2004 Sep 10;128(1):1-7.
RGD ID: 2317734
Pubmed: PMID:15337312   (View Abstract at PubMed)
DOI: DOI:10.1016/j.molbrainres.2004.05.023   (Journal Full-text)

The hallmarks of Alzheimer's disease (AD) brains are deposition of Abeta plaques, appearance of neurofibrillary tangles, and extensive loss of neuronal cells. While Abeta plaques and neurofibrillary tangles play a significant role in the pathogenic dysfunction of neurons, factors that accelerate the neurodegenerating process remain to be defined. One set of factors examined in this study is the Mre11 protein complex, composed of Rad50, Mre11 and Nbs1. This protein complex plays an essential role in cellular responses to DNA damage, such as initiating cell cycle checkpoints and repairing damaged DNA. A defect in any component of this protein complex is detrimental to cells. Recently, several groups have observed abnormal cell cycle regulation and/or accumulated DNA damage in AD neurons. These pathological alterations could conceivably be caused or exacerbated by any compromise in the Mre11 complex. In this study, we compared the levels of the Mre11 complex proteins in brain samples from AD and age-matched non-dementia controls. We show for the first time that the Mre11 complex proteins are present in neurons of the adult human cortex and cerebellum. These proteins were found substantially reduced in the neurons of AD cortex. Our finding suggests that the loss of the Mre11 complex may be associated with the pathogenesis of AD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease  IEP 2317734protein:decreased expression:cerebral cortex (human)RGD 
Alzheimer's disease  ISOMRE11 (Homo sapiens)2317734; 2317734protein:decreased expression:cerebral cortex (human)RGD 
Alzheimer's disease  IEP 2317734 RGD 
Alzheimer's disease  ISONBN (Homo sapiens)2317734; 2317734 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mre11  (MRE11 homolog, double strand break repair nuclease)
Nbn  (nibrin)

Genes (Mus musculus)
Mre11a  (MRE11A homolog A, double strand break repair nuclease)
Nbn  (nibrin)

Genes (Homo sapiens)
MRE11  (MRE11 homolog, double strand break repair nuclease)
NBN  (nibrin)


Additional Information