Rapgef4 (Rap guanine nucleotide exchange factor 4) - Rat Genome Database

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Gene: Rapgef4 (Rap guanine nucleotide exchange factor 4) Heterocephalus glaber
Analyze
Symbol: Rapgef4
Name: Rap guanine nucleotide exchange factor 4
RGD ID: 18912300
Description: ENCODES a protein that exhibits cAMP binding (ortholog); guanyl-nucleotide exchange factor activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); calcium-ion regulated exocytosis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Burns (ortholog); split hand-foot malformation 5 (ortholog); FOUND IN apical plasma membrane (ortholog); axon (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478710,062,717 - 10,369,632 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478710,062,677 - 10,369,132 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Rapgef4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478710,062,717 - 10,369,632 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478710,062,677 - 10,369,132 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
RAPGEF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382172,735,318 - 173,052,893 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2172,735,274 - 173,052,893 (+)EnsemblGRCh38hg38GRCh38
GRCh372173,600,573 - 173,917,621 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362173,308,771 - 173,625,867 (+)NCBINCBI36Build 36hg18NCBI36
Build 342173,426,113 - 173,743,122NCBI
Celera2167,213,920 - 167,531,026 (+)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2165,478,909 - 165,797,009 (+)NCBIHuRef
CHM1_12173,607,657 - 173,924,727 (+)NCBICHM1_1
T2T-CHM13v2.02173,221,758 - 173,539,439 (+)NCBIT2T-CHM13v2.0
Rapgef4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39271,811,559 - 72,087,818 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl271,811,584 - 72,087,818 (+)EnsemblGRCm39 Ensembl
GRCm38271,981,215 - 72,257,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl271,981,240 - 72,257,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv37271,819,344 - 72,094,433 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36271,782,126 - 72,057,215 (+)NCBIMGSCv36mm8
Celera273,684,323 - 73,945,757 (+)NCBICelera
Cytogenetic Map2C3NCBI
cM Map242.9NCBI
Rapgef4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8377,217,024 - 77,509,933 (+)NCBIGRCr8
mRatBN7.2356,809,388 - 57,101,332 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl356,809,270 - 57,102,316 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx360,204,514 - 60,496,004 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0368,788,153 - 69,079,646 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0366,553,199 - 66,844,692 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0358,632,338 - 58,925,127 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl358,632,476 - 58,924,038 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0365,122,705 - 65,409,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4354,396,312 - 54,717,148 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1354,578,917 - 54,613,517 (+)NCBI
Celera356,352,070 - 56,643,335 (+)NCBICelera
Cytogenetic Map3q23NCBI
Rapgef4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554492,171,924 - 2,462,451 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554492,172,354 - 2,453,367 (-)NCBIChiLan1.0ChiLan1.0
RAPGEF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21375,410,092 - 75,727,470 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B75,425,073 - 75,742,443 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B60,022,738 - 60,339,981 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B177,485,404 - 177,794,769 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B177,655,733 - 177,793,644 (+)Ensemblpanpan1.1panPan2
RAPGEF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13617,087,488 - 17,323,504 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3617,087,488 - 17,323,220 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3617,044,798 - 17,327,450 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03617,166,818 - 17,450,241 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3617,166,807 - 17,450,214 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13617,247,410 - 17,530,838 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03617,246,048 - 17,529,604 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03617,349,948 - 17,632,781 (+)NCBIUU_Cfam_GSD_1.0
Rapgef4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303134,168,378 - 134,452,112 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365092,722,428 - 3,005,288 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365092,722,279 - 3,006,436 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAPGEF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1578,773,266 - 79,095,040 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11578,773,270 - 79,094,490 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21588,093,533 - 88,416,683 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAPGEF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11058,233,503 - 58,549,337 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1058,233,654 - 58,549,331 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040141,024,710 - 141,334,996 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000006552   ⟹   ENSHGLP00000006470
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462478710,062,717 - 10,369,632 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000006553   ⟹   ENSHGLP00000006471
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462478710,062,717 - 10,369,632 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000006554   ⟹   ENSHGLP00000006472
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462478710,149,893 - 10,369,632 (+)Ensembl
RefSeq Acc Id: XM_004857682   ⟹   XP_004857739
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478710,062,677 - 10,369,132 (+)NCBI
RefSeq Acc Id: XM_004857683   ⟹   XP_004857740
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478710,062,677 - 10,369,132 (+)NCBI
RefSeq Acc Id: XM_004857684   ⟹   XP_004857741
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478710,150,266 - 10,369,132 (+)NCBI
RefSeq Acc Id: XM_013076960   ⟹   XP_012932414
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478710,196,935 - 10,369,132 (+)NCBI
RefSeq Acc Id: XM_013076961   ⟹   XP_012932415
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478710,254,050 - 10,369,132 (+)NCBI
RefSeq Acc Id: XM_021238644   ⟹   XP_021094303
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478710,191,133 - 10,369,132 (+)NCBI
RefSeq Acc Id: XM_021238645   ⟹   XP_021094304
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478710,186,435 - 10,369,132 (+)NCBI
RefSeq Acc Id: XM_021238647   ⟹   XP_021094306
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478710,196,935 - 10,369,132 (+)NCBI
RefSeq Acc Id: XM_021238648   ⟹   XP_021094307
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478710,254,218 - 10,369,132 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_004857739   ⟸   XM_004857682
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JX47 (UniProtKB/TrEMBL),   G5ALR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004857740   ⟸   XM_004857683
- Peptide Label: isoform X2
- UniProtKB: G5ALR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004857741   ⟸   XM_004857684
- Peptide Label: isoform X5
- UniProtKB: G5ALR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021094304   ⟸   XM_021238645
- Peptide Label: isoform X4
- UniProtKB: G5ALR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021094303   ⟸   XM_021238644
- Peptide Label: isoform X3
- UniProtKB: G5ALR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012932414   ⟸   XM_013076960
- Peptide Label: isoform X6
- UniProtKB: G5ALR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021094306   ⟸   XM_021238647
- Peptide Label: isoform X7
- UniProtKB: G5ALR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012932415   ⟸   XM_013076961
- Peptide Label: isoform X8
- UniProtKB: G5ALR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021094307   ⟸   XM_021238648
- Peptide Label: isoform X9
- UniProtKB: G5ALR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000006470   ⟸   ENSHGLT00000006552
RefSeq Acc Id: ENSHGLP00000006472   ⟸   ENSHGLT00000006554
RefSeq Acc Id: ENSHGLP00000006471   ⟸   ENSHGLT00000006553


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000004731 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000006552 ENTREZGENE
  ENSHGLT00000006553 ENTREZGENE
  ENSHGLT00000006554 ENTREZGENE
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.10.8.1240 UniProtKB/TrEMBL
  1.10.840.10 UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/TrEMBL
  DEP_dom UniProtKB/TrEMBL
  Ras-like_GEF UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/TrEMBL
  Ras_G-nucl-exch_fac_CS UniProtKB/TrEMBL
  Ras_GEF_dom_sf UniProtKB/TrEMBL
  RASGEF_cat_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report hgl:101706913 UniProtKB/TrEMBL
NCBI Gene Rapgef4 ENTREZGENE
PANTHER PTHR23113 UniProtKB/TrEMBL
  RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4 UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/TrEMBL
  DEP UniProtKB/TrEMBL
  RasGEF UniProtKB/TrEMBL
  RasGEF_N UniProtKB/TrEMBL
PRINTS CAMPKINASE UniProtKB/TrEMBL
PROSITE CNMP_BINDING_3 UniProtKB/TrEMBL
  DEP UniProtKB/TrEMBL
  RASGEF UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/TrEMBL
SMART cNMP UniProtKB/TrEMBL
  DEP UniProtKB/TrEMBL
  RasGEF UniProtKB/TrEMBL
  RasGEFN UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
  SSF48366 UniProtKB/TrEMBL
  SSF51206 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A0P6JX47 ENTREZGENE, UniProtKB/TrEMBL
  G5ALR1 ENTREZGENE, UniProtKB/TrEMBL