Cbr3 (carbonyl reductase 3) - Rat Genome Database

Name: Cbr3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Cbr3 (carbonyl reductase 3) Heterocephalus glaber

Analyze

Symbol:

Cbr3

Name:

carbonyl reductase 3

RGD ID:

18907711

Description:

ENCODES a protein that exhibits 3-keto sterol reductase activity (ortholog); carbonyl reductase (NADPH) activity (ortholog); NADPH binding (ortholog); INVOLVED IN cognition (ortholog); phylloquinone catabolic process (ortholog); PARTICIPATES IN doxorubicin pharmacokinetics pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 7 (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

carbonyl reductase [NADPH] 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CBR3 (carbonyl reductase 3)	NCBI	Ortholog
Mus musculus (house mouse):	Cbr3 (carbonyl reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cbr3 (carbonyl reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cbr3 (carbonyl reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CBR3 (carbonyl reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CBR3 (carbonyl reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cbr3 (carbonyl reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CBR3 (carbonyl reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CBR3 (carbonyl reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	27,294,222 - 27,305,109 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624745	27,298,714 - 27,305,606 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis type 1 (ISO)

autism spectrum disorder (ISO)

autosomal dominant intellectual developmental disorder 7 (ISO)

holocarboxylase synthetase deficiency (ISO)

Mouth Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cognition (ISO)

phylloquinone catabolic process (ISO)

Cellular Component

cytosol (ISO)

nucleoplasm (ISO)

Molecular Function

3-keto sterol reductase activity (ISO)

carbonyl reductase (NADPH) activity (ISO)

NADPH binding (ISO)

NADPH dehydrogenase (quinone) activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

doxorubicin pharmacokinetics pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Cbr3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	27,294,222 - 27,305,109 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624745	27,298,714 - 27,305,606 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

CBR3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	36,135,079 - 36,146,562 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	36,135,079 - 36,146,562 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	21	37,507,377 - 37,518,860 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	36,429,133 - 36,440,730 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	21	36,364,264 - 36,440,724	NCBI
Celera	21	22,706,132 - 22,717,559 (+)	NCBI		Celera
Cytogenetic Map	21	q22.12	NCBI
HuRef	21	22,984,935 - 22,996,359 (+)	NCBI		HuRef
CHM1_1	21	37,069,046 - 37,080,642 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	21	34,518,104 - 34,529,412 (+)	NCBI		T2T-CHM13v2.0

Cbr3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	93,480,107 - 93,487,879 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	93,480,103 - 93,487,878 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	93,683,219 - 93,690,991 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	93,683,215 - 93,690,990 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	93,683,464 - 93,691,236 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	93,571,759 - 93,579,527 (+)	NCBI		MGSCv36	mm8
Celera	16	94,777,963 - 94,785,655 (+)	NCBI		Celera
Cytogenetic Map	16	C4	NCBI
cM Map	16	54.58	NCBI

Cbr3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	46,478,295 - 46,486,555 (+)	NCBI		GRCr8
mRatBN7.2	11	33,008,615 - 33,016,877 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	33,008,615 - 33,016,875 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	41,662,664 - 41,670,924 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	34,334,206 - 34,342,467 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	33,484,246 - 33,492,418 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	33,909,417 - 33,917,674 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	33,909,439 - 33,917,674 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	37,500,661 - 37,508,918 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	33,913,961 - 33,922,221 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	33,961,819 - 33,978,463 (+)	NCBI
Celera	11	35,427,193 - 35,435,432 (-)	NCBI		Celera
Cytogenetic Map	11	q11	NCBI

Cbr3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	35,419,674 - 35,428,270 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955407	35,419,674 - 35,428,270 (+)	NCBI	ChiLan1.0	ChiLan1.0

CBR3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	32,256,031 - 32,267,414 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	27,115,995 - 27,128,098 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	22,505,647 - 22,516,938 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	35,865,374 - 35,876,717 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	35,865,374 - 35,876,717 (+)	Ensembl	panpan1.1		panPan2

CBR3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	31,416,441 - 31,423,797 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	31,416,333 - 31,423,739 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	30,472,787 - 30,480,043 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	30,713,351 - 30,720,605 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	30,713,139 - 30,720,547 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	30,585,631 - 30,592,893 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	30,599,689 - 30,606,933 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	31,090,527 - 31,097,817 (+)	NCBI		UU_Cfam_GSD_1.0

Cbr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	30,998,820 - 31,006,047 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936500	6,458,721 - 6,591,928 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936500	6,461,776 - 6,469,063 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CBR3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	199,830,668 - 199,840,442 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	199,830,690 - 199,840,444 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	209,842,863 - 209,852,618 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CBR3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	80,158,842 - 80,164,208 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	80,158,806 - 80,164,248 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	7,988,123 - 7,999,978 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_004842402	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01025482	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSHGLT00000018410 ⟹ ENSHGLP00000018229

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624745	27,294,222 - 27,305,109 (-)	Ensembl

RefSeq Acc Id:

XM_004842402 ⟹ XP_004842459

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624745	27,298,714 - 27,305,606 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_004842459	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000018229

RefSeq Acc Id:

XP_004842459 ⟸ XM_004842402

RefSeq Acc Id:

ENSHGLP00000018229 ⟸ ENSHGLT00000018410

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000013040	Ensembl, ENTREZGENE
Ensembl Transcript	ENSHGLT00000018410	ENTREZGENE
NCBI Gene	Cbr3	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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Imported Annotations - SMPDB