Ptk2b (protein tyrosine kinase 2 beta) - Rat Genome Database

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Pathways
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Gene: Ptk2b (protein tyrosine kinase 2 beta) Heterocephalus glaber
Analyze
Symbol: Ptk2b
Name: protein tyrosine kinase 2 beta
RGD ID: 18900931
Description: ENCODES a protein that exhibits 3-phosphoinositide-dependent protein kinase binding (ortholog); calmodulin-dependent protein kinase activity (ortholog); enzyme binding (ortholog); INVOLVED IN actin filament organization (ortholog); activation of GTPase activity (ortholog); activation of Janus kinase activity (ortholog); PARTICIPATES IN endothelin signaling pathway; fibroblast growth factor signaling pathway; interleukin-2 signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); anti-basement membrane glomerulonephritis (ortholog); bone disease (ortholog); FOUND IN apical dendrite (ortholog); axon (ortholog); cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein-tyrosine kinase 2-beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475822,124,836 - 22,182,605 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475822,065,448 - 22,182,604 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (ISO)
activation of GTPase activity  (ISO)
activation of Janus kinase activity  (ISO)
angiogenesis  (IEA,ISO)
blood vessel endothelial cell migration  (ISO)
bone resorption  (IEA)
cell adhesion  (ISO)
cell differentiation  (ISO)
cell surface receptor signaling pathway  (IEA)
cellular defense response  (ISO)
cellular response to fluid shear stress  (IEA,ISO)
cellular response to retinoic acid  (IEA)
chemokine-mediated signaling pathway  (IEA)
cortical cytoskeleton organization  (IEA)
endothelin receptor signaling pathway  (IEA)
epidermal growth factor receptor signaling pathway  (ISO)
focal adhesion assembly  (ISO)
glial cell proliferation  (ISO)
integrin-mediated signaling pathway  (IEA)
ionotropic glutamate receptor signaling pathway  (ISO)
long-term synaptic depression  (ISO)
long-term synaptic potentiation  (ISO)
MAPK cascade  (ISO)
marginal zone B cell differentiation  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of bone mineralization  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of myeloid cell differentiation  (IEA)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of ossification  (ISO)
negative regulation of potassium ion transport  (IEA)
neuron projection development  (ISO)
oocyte maturation  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of actin filament polymerization  (IEA)
positive regulation of angiogenesis  (IEA)
positive regulation of B cell chemotaxis  (IEA)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cell-matrix adhesion  (IEA)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of endothelial cell migration  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of JNK cascade  (IEA)
positive regulation of JUN kinase activity  (ISO)
positive regulation of neuron projection development  (IEA)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of protein metabolic process  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
positive regulation of translation  (ISO)
positive regulation of ubiquitin-dependent protein catabolic process  (IEA)
postsynaptic modulation of chemical synaptic transmission  (ISO)
regulation of actin cytoskeleton organization  (IEA)
regulation of biological quality  (IEA)
regulation of cell adhesion  (IEA)
regulation of cell shape  (IEA)
regulation of cellular component organization  (IEA)
regulation of macrophage chemotaxis  (IEA)
regulation of multicellular organismal process  (IEA)
regulation of postsynaptic density assembly  (IEA)
regulation of release of sequestered calcium ion into cytosol  (IEA)
regulation of ubiquitin-dependent protein catabolic process  (IEA)
response to calcium ion  (ISO)
response to cAMP  (ISO)
response to cation stress  (ISO)
response to cocaine  (ISO)
response to ethanol  (ISO)
response to glucose  (ISO)
response to hormone  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to immobilization stress  (ISO)
response to ischemia  (ISO)
response to mechanical stimulus  (ISO)
response to organonitrogen compound  (ISO)
response to reactive oxygen species  (ISO)
response to xenobiotic stimulus  (ISO)
signal complex assembly  (IEA)
sprouting angiogenesis  (IEA)
stress fiber assembly  (ISO)
tumor necrosis factor-mediated signaling pathway  (IEA)
vascular endothelial growth factor receptor signaling pathway  (IEA)

References
Additional References at PubMed
PMID:21993625   PMID:22301074  


Genomics

Comparative Map Data
Ptk2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475822,124,836 - 22,182,605 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475822,065,448 - 22,182,604 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PTK2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38827,310,506 - 27,459,391 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl827,311,482 - 27,459,391 (+)EnsemblGRCh38hg38GRCh38
GRCh37827,168,995 - 27,316,908 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,224,916 - 27,372,820 (+)NCBINCBI36Build 36hg18NCBI36
Build 34827,238,970 - 27,372,820NCBI
Celera826,131,907 - 26,277,021 (+)NCBICelera
Cytogenetic Map8p21.2NCBI
HuRef825,714,123 - 25,861,970 (+)NCBIHuRef
CHM1_1827,370,923 - 27,518,777 (+)NCBICHM1_1
T2T-CHM13v2.0827,583,138 - 27,736,745 (+)NCBIT2T-CHM13v2.0
Ptk2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,390,706 - 66,518,549 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1466,390,706 - 66,518,501 (-)EnsemblGRCm39 Ensembl
GRCm381466,153,257 - 66,281,100 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1466,153,257 - 66,281,052 (-)EnsemblGRCm38mm10GRCm38
MGSCv371466,772,094 - 66,899,889 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361465,107,372 - 65,235,162 (-)NCBIMGSCv36mm8
Celera1463,901,704 - 64,032,818 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
Ptk2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81544,536,275 - 44,656,754 (-)NCBIGRCr8
mRatBN7.21540,360,722 - 40,481,235 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,360,723 - 40,481,282 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,228,028 - 42,348,822 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,378,225 - 43,499,021 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,821,037 - 41,941,390 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01542,827,306 - 42,947,796 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,827,310 - 42,947,656 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,646,476 - 48,766,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,589,222 - 45,717,866 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11545,604,992 - 45,733,824 (-)NCBI
Celera1540,034,001 - 40,153,993 (-)NCBICelera
Cytogenetic Map15p12NCBI
Ptk2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540349,855,541 - 49,973,225 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540349,856,056 - 49,970,800 (+)NCBIChiLan1.0ChiLan1.0
PTK2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2745,841,364 - 45,989,859 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1821,555,525 - 21,704,087 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0826,580,855 - 26,729,378 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1823,783,624 - 23,932,472 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl823,869,825 - 23,932,474 (+)Ensemblpanpan1.1panPan2
PTK2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12530,137,546 - 30,264,221 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2530,138,209 - 30,264,133 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2530,723,893 - 30,850,311 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02530,327,673 - 30,454,390 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2530,327,667 - 30,454,389 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12530,257,967 - 30,384,306 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02530,138,848 - 30,265,191 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02530,305,247 - 30,431,983 (-)NCBIUU_Cfam_GSD_1.0
Ptk2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049438,260,472 - 8,369,219 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936675275,288 - 324,810 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936675216,970 - 325,670 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTK2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1411,064,492 - 11,194,192 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11411,063,662 - 11,194,196 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21412,244,257 - 12,375,188 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTK2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1825,437,680 - 25,571,594 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl825,437,564 - 25,571,782 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605216,572,610 - 16,706,737 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000021579   ⟹   ENSHGLP00000021370
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475822,124,836 - 22,182,605 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000021580   ⟹   ENSHGLP00000021371
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475822,125,297 - 22,181,764 (+)Ensembl
RefSeq Acc Id: XM_004848382   ⟹   XP_004848439
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475822,065,590 - 22,182,604 (+)NCBI
RefSeq Acc Id: XM_004848383   ⟹   XP_004848440
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475822,065,448 - 22,182,604 (+)NCBI
RefSeq Acc Id: XM_013073413   ⟹   XP_012928867
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475822,065,589 - 22,181,735 (+)NCBI
RefSeq Acc Id: XM_021261314   ⟹   XP_021116973
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475822,101,471 - 22,182,604 (+)NCBI
RefSeq Acc Id: XM_021261315   ⟹   XP_021116974
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475822,157,773 - 22,182,604 (+)NCBI
RefSeq Acc Id: XM_021261316   ⟹   XP_021116975
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475822,065,588 - 22,172,789 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_004848440   ⟸   XM_004848383
- Peptide Label: isoform X1
- UniProtKB: G5BY94 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021116975   ⟸   XM_021261316
- Peptide Label: isoform X4
RefSeq Acc Id: XP_012928867   ⟸   XM_013073413
- Peptide Label: isoform X2
RefSeq Acc Id: XP_004848439   ⟸   XM_004848382
- Peptide Label: isoform X1
- UniProtKB: G5BY94 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021116973   ⟸   XM_021261314
- Peptide Label: isoform X1
- UniProtKB: G5BY94 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021116974   ⟸   XM_021261315
- Peptide Label: isoform X3
RefSeq Acc Id: ENSHGLP00000021371   ⟸   ENSHGLT00000021580
RefSeq Acc Id: ENSHGLP00000021370   ⟸   ENSHGLT00000021579


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000015272 Ensembl, ENTREZGENE
  ENSHGLG00100018816 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000021579 ENTREZGENE
  ENSHGLT00100025919 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  Nucleotidyltransferases domain 2 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  FADK_N UniProtKB/TrEMBL
  FAK1-like_FERM_C UniProtKB/TrEMBL
  FAK1/PYK2_FERM_C UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  Focal_adhe_kin_target_dom_sf UniProtKB/TrEMBL
  Focal_adhesion_kin_target_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
KEGG Report hgl:101714384 UniProtKB/TrEMBL
NCBI Gene Ptk2b ENTREZGENE
PANTHER FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER UniProtKB/TrEMBL
  NON-SPECIFIC PROTEIN-TYROSINE KINASE UniProtKB/TrEMBL
Pfam FERM_C_FAK1 UniProtKB/TrEMBL
  FERM_M UniProtKB/TrEMBL
  FERM_N_2 UniProtKB/TrEMBL
  Focal_AT UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE FERM_3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47031 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF68993 UniProtKB/TrEMBL
UniProt G5BY94 ENTREZGENE, UniProtKB/TrEMBL