RGD Reference Report - Calcium-dependent activation of Pyk2 by hypoxia. - Rat Genome Database

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Calcium-dependent activation of Pyk2 by hypoxia.

Authors: Beitner-Johnson, D  Ferguson, T  Rust, RT  Kobayashi, S  Millhorn, DE 
Citation: Beitner-Johnson D, etal., Cell Signal. 2002 Feb;14(2):133-7.
RGD ID: 1642636
Pubmed: PMID:11781137   (View Abstract at PubMed)

The Pyk2 tyrosine kinase can be activated by both calcium-dependent and calcium-independent mechanisms. Exposure to moderate hypoxia (5% O(2)) induced a rapid and persistent tyrosine phosphorylation of Pyk2 in pheochromocytoma (PC12) cells. Hypoxia and KCl-depolarization increased the phosphotyrosine content of Pyk2 by twofold and fourfold, respectively. Both of these effects were abolished in the absence of extracellular calcium. There was a modest activation of MAPK in parallel with the onset of Pyk2 phosphorylation. However, there was no detectable activation of either JNK or c-src, two other known downstream targets of Pyk2. Thus, exposure to hypoxia may selectively target specific subsets of Pyk2 signalling pathways.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Ptk2bRatresponse to hypoxia  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptk2b  (protein tyrosine kinase 2 beta)


Additional Information