FGD3 (FYVE, RhoGEF and PH domain containing 3) - Rat Genome Database

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Gene: FGD3 (FYVE, RhoGEF and PH domain containing 3) Chlorocebus sabaeus
Analyze
Symbol: FGD3
Name: FYVE, RhoGEF and PH domain containing 3
RGD ID: 18777999
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); metal ion binding (inferred); INVOLVED IN cytoskeleton organization (inferred); filopodium assembly (inferred); FOUND IN cytoplasm (inferred); cytoskeleton (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: FYVE, RhoGEF and PH domain-containing protein 3; LOC103219910; uncharacterized LOC103219910; uncharacterized protein LOC103219910
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112103,368,267 - 103,424,194 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12103,368,236 - 103,424,504 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603891,609,869 - 91,696,232 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytoskeleton  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FGD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112103,368,267 - 103,424,194 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12103,368,236 - 103,424,504 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603891,609,869 - 91,696,232 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
FGD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38992,947,523 - 93,036,233 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl992,947,523 - 93,036,236 (+)EnsemblGRCh38hg38GRCh38
GRCh37995,709,805 - 95,798,515 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36994,749,422 - 94,838,339 (+)NCBINCBI36Build 36hg18NCBI36
Celera966,151,416 - 66,240,262 (+)NCBICelera
Cytogenetic Map9q22.31NCBI
HuRef965,386,766 - 65,475,463 (+)NCBIHuRef
CHM1_1995,856,394 - 95,945,176 (+)NCBICHM1_1
T2T-CHM13v2.09105,114,201 - 105,202,903 (+)NCBIT2T-CHM13v2.0
Fgd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391349,415,030 - 49,473,783 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1349,415,030 - 49,473,787 (-)EnsemblGRCm39 Ensembl
GRCm381349,261,554 - 49,320,313 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1349,261,554 - 49,320,311 (-)EnsemblGRCm38mm10GRCm38
MGSCv371349,358,479 - 49,404,577 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361349,275,047 - 49,321,145 (-)NCBIMGSCv36mm8
Celera1350,352,639 - 50,398,634 (-)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1325.18NCBI
Fgd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81715,531,237 - 15,593,678 (+)NCBIGRCr8
mRatBN7.21715,324,848 - 15,387,271 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1715,336,837 - 15,385,712 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1715,223,559 - 15,272,757 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01716,828,621 - 16,877,816 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01715,150,350 - 15,199,536 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01715,737,962 - 15,800,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1715,749,978 - 15,800,401 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01717,807,528 - 17,855,077 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41721,292,539 - 21,343,264 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11721,306,219 - 21,342,775 (+)NCBI
Celera1715,067,402 - 15,115,963 (+)NCBICelera
Cytogenetic Map17p14NCBI
Fgd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555154,968,504 - 5,025,633 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555154,967,862 - 5,025,604 (-)NCBIChiLan1.0ChiLan1.0
FGD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21146,391,579 - 46,480,368 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1946,393,965 - 46,482,747 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0964,071,083 - 64,159,854 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1992,138,743 - 92,226,835 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl992,138,743 - 92,226,835 (+)Ensemblpanpan1.1panPan2
FGD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1198,624,529 - 98,696,916 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl198,625,138 - 98,648,839 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha199,018,508 - 99,048,949 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0199,241,437 - 99,271,847 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl199,241,434 - 99,271,747 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1198,854,618 - 98,885,002 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0198,589,955 - 98,620,404 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0199,345,579 - 99,375,989 (-)NCBIUU_Cfam_GSD_1.0
Fgd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049448,165,569 - 8,206,669 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364872,388,807 - 2,421,350 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364872,385,732 - 2,422,326 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl342,540,550 - 42,596,528 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1342,457,072 - 42,587,585 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Fgd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248683,506,662 - 3,542,359 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248683,507,448 - 3,560,639 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 20
Low 36 60
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000005210   ⟹   ENSCSAP00000003439
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl12103,368,236 - 103,424,504 (+)Ensembl
RefSeq Acc Id: XM_007969765   ⟹   XP_007967956
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.112103,368,267 - 103,424,194 (+)NCBI
Vero_WHO_p1.0NW_02366603891,627,436 - 91,696,232 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007969766   ⟹   XP_007967957
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.112103,368,358 - 103,424,194 (+)NCBI
Vero_WHO_p1.0NW_02366603891,627,253 - 91,696,232 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037998625   ⟹   XP_037854553
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603891,629,419 - 91,696,232 (+)NCBI
RefSeq Acc Id: XM_037998626   ⟹   XP_037854554
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603891,627,436 - 91,696,232 (+)NCBI
RefSeq Acc Id: XM_037998627   ⟹   XP_037854555
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603891,627,436 - 91,696,232 (+)NCBI
RefSeq Acc Id: XM_037998628   ⟹   XP_037854556
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603891,634,995 - 91,696,232 (+)NCBI
RefSeq Acc Id: XM_037998629   ⟹   XP_037854557
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603891,610,074 - 91,696,232 (+)NCBI
RefSeq Acc Id: XM_037998630   ⟹   XP_037854558
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603891,634,995 - 91,696,232 (+)NCBI
RefSeq Acc Id: XM_037998631   ⟹   XP_037854559
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603891,629,419 - 91,696,232 (+)NCBI
RefSeq Acc Id: XM_037998632   ⟹   XP_037854560
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603891,609,869 - 91,696,232 (+)NCBI
RefSeq Acc Id: XP_007967956   ⟸   XM_007969765
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R4A0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007967957   ⟸   XM_007969766
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R4A0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000003439   ⟸   ENSCSAT00000005210
RefSeq Acc Id: XP_037854560   ⟸   XM_037998632
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R4A0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037854557   ⟸   XM_037998629
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R4A0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037854554   ⟸   XM_037998626
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R4A0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037854555   ⟸   XM_037998627
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R4A0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037854553   ⟸   XM_037998625
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R4A0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037854559   ⟸   XM_037998631
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R4A0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037854556   ⟸   XM_037998628
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R4A0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037854558   ⟸   XM_037998630
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R4A0 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000007165 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000005210.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  FGD1-4_PH2 UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Znf_FYVE UniProtKB/TrEMBL
  Znf_FYVE-rel UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report csab:103219761 UniProtKB/TrEMBL
NCBI Gene FGD3 ENTREZGENE
PANTHER FACIOGENITAL DYSPLASIA PROTEIN UniProtKB/TrEMBL
  FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 3 UniProtKB/TrEMBL
Pfam FYVE UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
PROSITE DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  ZF_FYVE UniProtKB/TrEMBL
SMART FYVE UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
  SSF57903 UniProtKB/TrEMBL
UniProt A0A0D9R4A0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-03 FGD3  FYVE, RhoGEF and PH domain containing 3  LOC103219910  uncharacterized LOC103219910  Data merged from RGD:18636920 737654 PROVISIONAL