NWD1 (NACHT and WD repeat domain containing 1) - Rat Genome Database

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Gene: NWD1 (NACHT and WD repeat domain containing 1) Chlorocebus sabaeus
Analyze
Symbol: NWD1
Name: NACHT and WD repeat domain containing 1
RGD ID: 18760320
Description: INVOLVED IN positive regulation of gene expression (ortholog); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN cytosol (ortholog); nucleolus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC103234115; NACHT and WD repeat domain-containing protein 1; NACHT and WD repeat domain-containing protein 1-like; NACHT domain- and WD repeat-containing protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1615,255,116 - 15,318,589 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl615,221,120 - 15,318,470 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660744,119,126 - 4,220,741 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (ISO)
nucleolus  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NWD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1615,255,116 - 15,318,589 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl615,221,120 - 15,318,470 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660744,119,126 - 4,220,741 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NWD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381916,719,847 - 16,817,963 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1916,719,847 - 16,817,963 (+)EnsemblGRCh38hg38GRCh38
GRCh371916,830,658 - 16,928,774 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361916,691,787 - 16,789,764 (+)NCBINCBI36Build 36hg18NCBI36
Celera1916,732,646 - 16,830,313 (+)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1916,399,721 - 16,497,684 (+)NCBIHuRef
CHM1_11916,830,805 - 16,928,529 (+)NCBICHM1_1
T2T-CHM13v2.01916,854,654 - 16,952,783 (+)NCBIT2T-CHM13v2.0
Nwd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39873,372,865 - 73,443,508 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl873,373,339 - 73,444,504 (+)EnsemblGRCm39 Ensembl
GRCm38872,646,225 - 72,716,880 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,646,711 - 72,717,876 (+)EnsemblGRCm38mm10GRCm38
MGSCv37875,170,610 - 75,238,645 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36875,540,415 - 75,604,144 (+)NCBIMGSCv36mm8
Celera876,962,656 - 77,030,120 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map835.08NCBI
Nwd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81617,204,731 - 17,278,184 (-)NCBIGRCr8
mRatBN7.21617,166,479 - 17,242,055 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1617,170,659 - 17,252,705 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01618,875,768 - 18,944,775 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1618,877,257 - 18,937,562 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01618,740,763 - 18,803,402 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1617,396,593 - 17,464,531 (-)NCBICelera
Cytogenetic Map16p14NCBI
Nwd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555241,084,750 - 1,121,689 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555241,083,237 - 1,122,615 (-)NCBIChiLan1.0ChiLan1.0
NWD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22021,591,857 - 21,688,508 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11920,598,431 - 20,695,014 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01916,209,324 - 16,305,897 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11917,189,728 - 17,283,045 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1917,202,805 - 17,281,335 (+)Ensemblpanpan1.1panPan2
NWD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12045,792,745 - 45,854,889 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2045,794,306 - 45,852,100 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2045,706,235 - 45,772,311 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02046,279,282 - 46,345,502 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2046,279,297 - 46,345,510 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12045,514,886 - 45,581,005 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02045,925,619 - 45,991,612 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02046,201,195 - 46,266,989 (-)NCBIUU_Cfam_GSD_1.0
Nwd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118204,330,959 - 204,399,516 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365963,884,269 - 3,942,406 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365963,882,259 - 3,948,664 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NWD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl260,800,438 - 60,906,046 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1260,800,064 - 60,906,536 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2260,406,949 - 60,494,692 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Nwd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624908799,402 - 828,353 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624908797,891 - 830,857 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 12
Low 19 16 47
Below cutoff 17 4 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000003732   ⟹   ENSCSAP00000002006
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl615,221,120 - 15,318,470 (+)Ensembl
RefSeq Acc Id: XM_007995660   ⟹   XP_007993851
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1615,255,116 - 15,318,589 (+)NCBI
Vero_WHO_p1.0NW_0236660744,119,126 - 4,220,741 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037992520   ⟹   XP_037848448
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660744,119,126 - 4,211,901 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007993851 (Get FASTA)   NCBI Sequence Viewer  
  XP_037848448 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000002006.1
Reference Protein Sequences
RefSeq Acc Id: XP_007993851   ⟸   XM_007995660
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R067 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000002006   ⟸   ENSCSAT00000003732
RefSeq Acc Id: XP_037848448   ⟸   XM_037992520
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R067 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000005700 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000003732.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro G-protein_beta_WD-40_rep UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/TrEMBL
  NWD1 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene NWD1 ENTREZGENE
PANTHER NACHT DOMAIN- AND WD REPEAT-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  PTHR45013 UniProtKB/TrEMBL
Pfam NACHT UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PRINTS GPROTEINBRPT UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A0D9R067 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-03 NWD1  NACHT and WD repeat domain containing 1  LOC103234115  NACHT and WD repeat domain-containing protein 1-like  Data merged from RGD:18642034 737654 PROVISIONAL