NPL (N-acetylneuraminate pyruvate lyase) - Rat Genome Database

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Gene: NPL (N-acetylneuraminate pyruvate lyase) Chlorocebus sabaeus
Analyze
Symbol: NPL
Name: N-acetylneuraminate pyruvate lyase
RGD ID: 18690978
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN carbohydrate metabolic process (inferred); N-acetylneuraminate catabolic process (inferred); PARTICIPATES IN amino sugar metabolic pathway; french type sialuria pathway; sialic acid storage disease pathway; ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); autosomal recessive chronic granulomatous disease 2 (ortholog); cholestasis (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: N-acetylneuraminate lyase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12546,543,645 - 46,582,700 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2546,541,401 - 46,581,767 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605547,760,165 - 47,800,243 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12546,543,645 - 46,582,700 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2546,541,401 - 46,581,767 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605547,760,165 - 47,800,243 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381182,789,773 - 182,830,384 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1182,789,293 - 182,830,384 (+)EnsemblGRCh38hg38GRCh38
GRCh371182,758,908 - 182,799,519 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361181,028,017 - 181,065,211 (+)NCBINCBI36Build 36hg18NCBI36
Build 341179,493,050 - 179,530,245NCBI
Celera1155,872,543 - 155,909,737 (+)NCBICelera
Cytogenetic Map1q25.3NCBI
HuRef1153,994,259 - 154,035,194 (+)NCBIHuRef
CHM1_11184,181,835 - 184,222,761 (+)NCBICHM1_1
T2T-CHM13v2.01182,148,939 - 182,189,548 (+)NCBIT2T-CHM13v2.0
Npl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,378,762 - 153,425,460 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,378,761 - 153,425,791 (-)EnsemblGRCm39 Ensembl
GRCm381153,503,016 - 153,549,714 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,503,015 - 153,550,045 (-)EnsemblGRCm38mm10GRCm38
MGSCv371155,350,146 - 155,396,844 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361155,265,234 - 155,311,932 (-)NCBIMGSCv36mm8
Celera1155,927,936 - 155,974,856 (-)NCBICelera
Cytogenetic Map1G3NCBI
cM Map165.38NCBI
Npl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81368,205,602 - 68,247,940 (-)NCBIGRCr8
mRatBN7.21365,655,099 - 65,697,464 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1365,655,118 - 65,697,372 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1368,258,125 - 68,300,390 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01369,546,594 - 69,588,750 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01366,798,071 - 66,840,251 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01370,938,073 - 70,981,179 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1370,938,082 - 70,980,913 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01375,903,277 - 75,946,223 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41368,524,023 - 68,567,312 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1365,558,454 - 65,600,109 (-)NCBICelera
Cytogenetic Map13q21NCBI
Npl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540621,633,032 - 21,670,958 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540621,633,979 - 21,670,279 (+)NCBIChiLan1.0ChiLan1.0
NPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2166,901,458 - 66,944,704 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,584,984 - 66,626,297 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01158,305,203 - 158,346,531 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11161,957,118 - 161,997,635 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1161,958,896 - 161,997,222 (+)Ensemblpanpan1.1panPan2
NPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1716,186,693 - 16,226,658 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl716,192,005 - 16,224,033 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha715,773,528 - 15,812,293 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0715,916,535 - 15,955,524 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl715,915,242 - 15,952,901 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1715,828,310 - 15,866,959 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0715,937,498 - 15,975,727 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0716,066,339 - 16,105,552 (+)NCBIUU_Cfam_GSD_1.0
Npl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934489,095,379 - 89,129,855 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364816,942,282 - 6,972,775 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364816,942,128 - 6,977,042 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9124,093,604 - 124,132,860 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19124,093,579 - 124,132,862 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Npl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462481410,968,329 - 10,994,001 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462481410,968,218 - 11,006,637 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 20
Low 36 60
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007989251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007989252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007989253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007989254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007989255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007989256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007989257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007989258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007989259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007989260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007989261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007989262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007989263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007989264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037985843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037985844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037985845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037985846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037985847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037985848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037985849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037985850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000010629   ⟹   ENSCSAP00000008718
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2546,541,401 - 46,581,767 (-)Ensembl
RefSeq Acc Id: XM_007989253   ⟹   XP_007987444
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12546,543,645 - 46,580,575 (-)NCBI
Vero_WHO_p1.0NW_02366605547,760,165 - 47,798,526 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007989254   ⟹   XP_007987445
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12546,543,645 - 46,581,764 (-)NCBI
Vero_WHO_p1.0NW_02366605547,760,173 - 47,799,742 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007989255   ⟹   XP_007987446
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12546,543,645 - 46,580,571 (-)NCBI
Vero_WHO_p1.0NW_02366605547,760,165 - 47,798,507 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007989257   ⟹   XP_007987448
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12546,543,645 - 46,582,058 (-)NCBI
Vero_WHO_p1.0NW_02366605547,760,165 - 47,800,243 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007989262   ⟹   XP_007987453
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12546,543,896 - 46,580,621 (-)NCBI
Vero_WHO_p1.0NW_02366605547,760,165 - 47,799,722 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007989263   ⟹   XP_007987454
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12546,543,645 - 46,581,783 (-)NCBI
Vero_WHO_p1.0NW_02366605547,760,165 - 47,799,747 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007989264   ⟹   XP_007987455
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12546,543,645 - 46,565,153 (-)NCBI
Vero_WHO_p1.0NW_02366605547,760,165 - 47,782,992 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037985843   ⟹   XP_037841771
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605547,760,165 - 47,799,722 (-)NCBI
RefSeq Acc Id: XM_037985844   ⟹   XP_037841772
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605547,760,165 - 47,799,737 (-)NCBI
RefSeq Acc Id: XM_037985845   ⟹   XP_037841773
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605547,760,165 - 47,798,526 (-)NCBI
RefSeq Acc Id: XM_037985846   ⟹   XP_037841774
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605547,760,165 - 47,798,409 (-)NCBI
RefSeq Acc Id: XM_037985847   ⟹   XP_037841775
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605547,760,165 - 47,798,409 (-)NCBI
RefSeq Acc Id: XM_037985848   ⟹   XP_037841776
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605547,760,165 - 47,799,689 (-)NCBI
RefSeq Acc Id: XM_037985849   ⟹   XP_037841777
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605547,760,165 - 47,798,526 (-)NCBI
RefSeq Acc Id: XM_037985850   ⟹   XP_037841778
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605547,760,165 - 47,799,722 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_007987448   ⟸   XM_007989257
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RJC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007987454   ⟸   XM_007989263
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RJC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007987445   ⟸   XM_007989254
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RJC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007987444   ⟸   XM_007989253
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RJC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007987446   ⟸   XM_007989255
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RJC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007987455   ⟸   XM_007989264
- Peptide Label: isoform X5
RefSeq Acc Id: XP_007987453   ⟸   XM_007989262
- Peptide Label: isoform X4
RefSeq Acc Id: ENSCSAP00000008718   ⟸   ENSCSAT00000010629
RefSeq Acc Id: XP_037841772   ⟸   XM_037985844
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RJC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037841778   ⟸   XM_037985850
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037841771   ⟸   XM_037985843
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RJC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037841776   ⟸   XM_037985848
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RJC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037841777   ⟸   XM_037985849
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RJC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037841773   ⟸   XM_037985845
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RJC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037841775   ⟸   XM_037985847
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RJC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037841774   ⟸   XM_037985846
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RJC9 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000012535 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000010629.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/TrEMBL
  DapA-like UniProtKB/TrEMBL
  NanA UniProtKB/TrEMBL
NCBI Gene NPL ENTREZGENE
PANTHER N-ACETYLNEURAMINATE LYASE UniProtKB/TrEMBL
  PTHR12128 UniProtKB/TrEMBL
Pfam DHDPS UniProtKB/TrEMBL
PIRSF DHDPS UniProtKB/TrEMBL
PRINTS DHPICSNTHASE UniProtKB/TrEMBL
SMART DHDPS UniProtKB/TrEMBL
Superfamily-SCOP Aldolase UniProtKB/TrEMBL
UniProt A0A0D9RJC9 ENTREZGENE, UniProtKB/TrEMBL