MYO15A (myosin XVA) - Rat Genome Database

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Gene: MYO15A (myosin XVA) Chlorocebus sabaeus
Analyze
Symbol: MYO15A
Name: myosin XVA
RGD ID: 18690773
Description: ENCODES a protein that exhibits actin binding (inferred); ATP binding (inferred); cytoskeletal motor activity (inferred); INVOLVED IN inner ear morphogenesis (ortholog); locomotory behavior (ortholog); response to light stimulus (ortholog); PARTICIPATES IN auditory mechanotransduction pathway; ASSOCIATED WITH Alport syndrome (ortholog); autistic disorder (ortholog); autosomal recessive nonsyndromic deafness (ortholog); FOUND IN stereocilium (ortholog); stereocilium bundle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: unconventional myosin-XV
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11617,157,275 - 17,217,609 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1617,157,490 - 17,218,009 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660593,687,568 - 3,750,880 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
MYO15A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11617,157,275 - 17,217,609 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1617,157,490 - 17,218,009 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660593,687,568 - 3,750,880 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MYO15A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381718,108,756 - 18,179,800 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1718,108,756 - 18,179,802 (+)EnsemblGRCh38hg38GRCh38
GRCh371718,012,070 - 18,083,114 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361717,952,745 - 18,023,841 (+)NCBINCBI36Build 36hg18NCBI36
Build 341717,952,744 - 18,023,840NCBI
Celera1718,953,160 - 19,024,251 (+)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1717,765,392 - 17,836,464 (+)NCBIHuRef
CHM1_11718,020,789 - 18,091,861 (+)NCBICHM1_1
T2T-CHM13v2.01718,055,569 - 18,126,619 (+)NCBIT2T-CHM13v2.0
Myo15a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,360,165 - 60,419,195 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1160,360,165 - 60,419,195 (+)EnsemblGRCm39 Ensembl
GRCm381160,469,339 - 60,528,369 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,469,339 - 60,528,369 (+)EnsemblGRCm38mm10GRCm38
MGSCv371160,282,841 - 60,341,871 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361161,007,838 - 61,067,005 (+)NCBIMGSCv36mm8
MGSCv361160,285,534 - 60,344,564 (+)NCBIMGSCv36mm8
Celera1164,710,231 - 64,711,213 (-)NCBICelera
Cytogenetic Map11B2NCBI
cM Map1137.81NCBI
Myo15a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81045,776,907 - 45,835,473 (+)NCBIGRCr8
mRatBN7.21045,277,619 - 45,335,953 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,278,737 - 45,335,340 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01046,840,098 - 46,897,362 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,840,113 - 46,896,054 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01046,595,676 - 46,660,835 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,742,535 - 46,798,928 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1044,535,548 - 44,591,592 (+)NCBICelera
Cytogenetic Map10q22NCBI
Myo15a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547811,132,719 - 11,186,378 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547811,131,908 - 11,186,465 (-)NCBIChiLan1.0ChiLan1.0
LOC100971960
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21953,085,248 - 53,159,407 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11757,796,388 - 57,870,842 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01732,661,499 - 32,723,320 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11738,033,646 - 38,091,376 (-)NCBIpanpan1.1PanPan1.1panPan2
MYO15A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1541,369,484 - 41,421,303 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl541,370,509 - 41,392,881 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha541,507,455 - 41,559,211 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0541,474,709 - 41,526,462 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1541,442,539 - 41,494,282 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0541,389,966 - 41,441,709 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0541,581,821 - 41,633,567 (-)NCBIUU_Cfam_GSD_1.0
Myo15a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560261,142,863 - 61,197,568 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367411,669,680 - 1,723,891 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367411,669,680 - 1,724,929 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYO15A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11260,533,502 - 60,582,645 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Myo15a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248493,284,085 - 3,344,759 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248493,283,180 - 3,345,456 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 20 22
Low 7 13 38
Below cutoff 9 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000006237   ⟹   ENSCSAP00000004443
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1617,157,490 - 17,218,009 (+)Ensembl
RefSeq Acc Id: XM_037987253   ⟹   XP_037843181
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660593,687,568 - 3,750,679 (-)NCBI
RefSeq Acc Id: XM_037987254   ⟹   XP_037843182
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660593,687,568 - 3,750,678 (-)NCBI
RefSeq Acc Id: XM_037987255   ⟹   XP_037843183
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660593,693,707 - 3,750,697 (-)NCBI
RefSeq Acc Id: XM_037987256   ⟹   XP_037843184
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660593,687,568 - 3,750,679 (-)NCBI
RefSeq Acc Id: XM_037987257   ⟹   XP_037843185
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660593,693,707 - 3,750,694 (-)NCBI
RefSeq Acc Id: XM_037987258   ⟹   XP_037843186
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660593,693,709 - 3,750,704 (-)NCBI
RefSeq Acc Id: XM_037987259   ⟹   XP_037843187
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660593,687,568 - 3,750,679 (-)NCBI
RefSeq Acc Id: XR_005236701
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660593,701,401 - 3,750,713 (-)NCBI
RefSeq Acc Id: XR_005236702
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660593,704,389 - 3,750,878 (-)NCBI
RefSeq Acc Id: XR_005236703
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660593,704,386 - 3,750,880 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000004443   ⟸   ENSCSAT00000006237
RefSeq Acc Id: XP_037843184   ⟸   XM_037987256
- Peptide Label: isoform X4
- UniProtKB: A0A0D9R754 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037843181   ⟸   XM_037987253
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R754 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037843187   ⟸   XM_037987259
- Peptide Label: isoform X7
- UniProtKB: A0A0D9R754 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037843182   ⟸   XM_037987254
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R754 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037843183   ⟸   XM_037987255
- Peptide Label: isoform X3
- UniProtKB: A0A0D9R754 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037843185   ⟸   XM_037987257
- Peptide Label: isoform X5
- UniProtKB: A0A0D9R754 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037843186   ⟸   XM_037987258
- Peptide Label: isoform X6
- UniProtKB: A0A0D9R754 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000008278 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000006237.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.820 UniProtKB/TrEMBL
  1.20.5.190 UniProtKB/TrEMBL
  1.20.58.530 UniProtKB/TrEMBL
  1.25.40.530 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/TrEMBL
  6.20.240.20 UniProtKB/TrEMBL
  Myosin VI head, motor domain, U50 subdomain UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro FERM_central UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/TrEMBL
  MyoXV_FERM_C UniProtKB/TrEMBL
  MYSc_Myo15 UniProtKB/TrEMBL
  MyTH4_dom UniProtKB/TrEMBL
  MyTH4_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene MYO15A ENTREZGENE
PANTHER MYOSIN VII, XV UniProtKB/TrEMBL
  PTHR22692:SF21 UniProtKB/TrEMBL
Pfam FERM_M UniProtKB/TrEMBL
  Myosin_head UniProtKB/TrEMBL
  MyTH4 UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
PRINTS MYOSINHEAVY UniProtKB/TrEMBL
PROSITE MYOSIN_MOTOR UniProtKB/TrEMBL
  MYTH4 UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART MYSc UniProtKB/TrEMBL
  MyTH4 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00015 UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A0D9R754 ENTREZGENE, UniProtKB/TrEMBL