GIT2 (GIT ArfGAP 2) - Rat Genome Database

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Gene: GIT2 (GIT ArfGAP 2) Chlorocebus sabaeus
Analyze
Symbol: GIT2
Name: GIT ArfGAP 2
RGD ID: 18606161
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN behavioral response to pain (ortholog); presynaptic modulation of chemical synaptic transmission (ortholog); regulation of synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH genetic disease (ortholog); inflammatory bowel disease (ortholog); FOUND IN calyx of Held (ortholog); presynapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ARF GTPase-activating protein GIT2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111105,171,441 - 105,235,661 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11105,169,099 - 105,235,290 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037139,885,173 - 139,947,837 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
calyx of Held  (ISO)
nucleoplasm  (IEA)
presynapse  (IEA,ISO)
synapse  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GIT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111105,171,441 - 105,235,661 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11105,169,099 - 105,235,290 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037139,885,173 - 139,947,837 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
GIT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812109,929,804 - 110,000,164 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12109,929,804 - 109,996,389 (-)EnsemblGRCh38hg38GRCh38
GRCh3712110,367,609 - 110,434,173 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612108,851,992 - 108,918,483 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412108,848,588 - 108,896,820NCBI
Celera12109,991,955 - 110,058,428 (-)NCBICelera
Cytogenetic Map12q24.11NCBI
HuRef12107,383,692 - 107,449,937 (-)NCBIHuRef
CHM1_112110,335,391 - 110,401,989 (-)NCBICHM1_1
T2T-CHM13v2.012109,905,496 - 109,975,853 (-)NCBIT2T-CHM13v2.0
Git2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395114,865,469 - 114,912,647 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5114,865,468 - 114,913,578 (-)EnsemblGRCm39 Ensembl
GRCm385114,727,408 - 114,774,588 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5114,727,407 - 114,775,517 (-)EnsemblGRCm38mm10GRCm38
MGSCv375115,177,417 - 115,223,501 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365114,988,410 - 115,034,490 (-)NCBIMGSCv36mm8
Celera5111,825,622 - 111,871,698 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.99NCBI
Git2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81247,490,350 - 47,531,232 (+)NCBIGRCr8
mRatBN7.21241,829,717 - 41,872,621 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,829,730 - 41,871,097 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,997,345 - 43,038,116 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,610,923 - 43,651,694 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,671,415 - 42,712,186 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,590,110 - 47,630,991 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,590,154 - 47,631,119 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01249,383,645 - 49,424,284 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,117,706 - 43,158,710 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11242,981,093 - 43,022,097 (+)NCBI
Celera1243,445,286 - 43,486,291 (+)NCBICelera
Cytogenetic Map12q16NCBI
Git2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554558,613,490 - 8,670,205 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554558,611,218 - 8,669,527 (+)NCBIChiLan1.0ChiLan1.0
GIT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210117,996,751 - 118,063,703 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112117,993,154 - 118,060,124 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012107,505,791 - 107,572,641 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112110,901,293 - 110,967,489 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12110,901,303 - 110,967,489 (-)Ensemblpanpan1.1panPan2
GIT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12617,170,651 - 17,217,634 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2617,170,680 - 17,214,631 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2618,584,319 - 18,631,531 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02617,515,164 - 17,562,316 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2617,515,162 - 17,562,313 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12618,794,107 - 18,841,098 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02617,504,924 - 17,552,144 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02617,522,393 - 17,569,401 (+)NCBIUU_Cfam_GSD_1.0
Git2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118143,901,711 - 143,948,385 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367691,527,151 - 1,574,892 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367691,529,983 - 1,574,805 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GIT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1440,995,988 - 41,051,902 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11440,995,986 - 41,051,896 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21443,511,566 - 43,567,474 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Git2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474710,518,671 - 10,580,179 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474710,518,651 - 10,580,179 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 17 59
Low 3 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008004653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008004654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008004655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008004656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008004657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008004658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008004659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008004660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008004661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008004662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008004663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008004664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008004665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008004666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008004668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008004669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008004670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008004671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008004672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037996551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037996552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037996554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000000733   ⟹   ENSCSAP00000015331
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl11105,169,099 - 105,235,290 (-)Ensembl
RefSeq Acc Id: XM_008004653   ⟹   XP_008002844
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111105,171,441 - 105,235,393 (-)NCBI
Vero_WHO_p1.0NW_023666037139,885,427 - 139,947,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004654   ⟹   XP_008002845
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111105,171,441 - 105,235,393 (-)NCBI
Vero_WHO_p1.0NW_023666037139,885,427 - 139,947,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004655   ⟹   XP_008002846
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111105,171,441 - 105,235,392 (-)NCBI
Vero_WHO_p1.0NW_023666037139,885,429 - 139,947,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004656   ⟹   XP_008002847
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111105,171,441 - 105,235,393 (-)NCBI
Vero_WHO_p1.0NW_023666037139,885,428 - 139,947,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004657   ⟹   XP_008002848
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111105,171,441 - 105,235,393 (-)NCBI
Vero_WHO_p1.0NW_023666037139,885,425 - 139,947,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004658   ⟹   XP_008002849
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111105,171,441 - 105,235,392 (-)NCBI
Vero_WHO_p1.0NW_023666037139,885,428 - 139,947,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004659   ⟹   XP_008002850
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111105,171,441 - 105,235,392 (-)NCBI
Vero_WHO_p1.0NW_023666037139,885,429 - 139,947,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004660   ⟹   XP_008002851
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111105,171,441 - 105,235,394 (-)NCBI
Vero_WHO_p1.0NW_023666037139,885,425 - 139,947,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004661   ⟹   XP_008002852
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111105,171,441 - 105,235,661 (-)NCBI
Vero_WHO_p1.0NW_023666037139,885,173 - 139,947,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004662   ⟹   XP_008002853
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111105,171,441 - 105,235,394 (-)NCBI
Vero_WHO_p1.0NW_023666037139,885,425 - 139,947,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004663   ⟹   XP_008002854
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111105,171,441 - 105,235,398 (-)NCBI
Vero_WHO_p1.0NW_023666037139,885,423 - 139,947,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004664   ⟹   XP_008002855
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111105,171,441 - 105,235,393 (-)NCBI
Vero_WHO_p1.0NW_023666037139,885,425 - 139,947,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004665   ⟹   XP_008002856
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111105,171,441 - 105,235,393 (-)NCBI
Vero_WHO_p1.0NW_023666037139,885,427 - 139,947,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004666   ⟹   XP_008002857
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111105,171,441 - 105,235,392 (-)NCBI
Vero_WHO_p1.0NW_023666037139,885,427 - 139,947,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004668   ⟹   XP_008002859
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111105,171,441 - 105,235,393 (-)NCBI
Vero_WHO_p1.0NW_023666037139,885,427 - 139,947,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004669   ⟹   XP_008002860
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111105,171,441 - 105,235,391 (-)NCBI
Vero_WHO_p1.0NW_023666037139,885,428 - 139,947,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004672   ⟹   XP_008002863
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111105,187,310 - 105,235,392 (-)NCBI
Vero_WHO_p1.0NW_023666037139,885,434 - 139,932,766 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037996551   ⟹   XP_037852479
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037139,885,425 - 139,947,837 (+)NCBI
RefSeq Acc Id: XM_037996552   ⟹   XP_037852480
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037139,885,425 - 139,947,837 (+)NCBI
RefSeq Acc Id: XM_037996554   ⟹   XP_037852482
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037139,885,428 - 139,947,837 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008002852   ⟸   XM_008004661
- Peptide Label: isoform X11
RefSeq Acc Id: XP_008002854   ⟸   XM_008004663
- Peptide Label: isoform X12
RefSeq Acc Id: XP_008002853   ⟸   XM_008004662
- Peptide Label: isoform X11
RefSeq Acc Id: XP_008002851   ⟸   XM_008004660
- Peptide Label: isoform X9
RefSeq Acc Id: XP_008002859   ⟸   XM_008004668
- Peptide Label: isoform X16
RefSeq Acc Id: XP_008002847   ⟸   XM_008004656
- Peptide Label: isoform X4
RefSeq Acc Id: XP_008002856   ⟸   XM_008004665
- Peptide Label: isoform X14
RefSeq Acc Id: XP_008002845   ⟸   XM_008004654
- Peptide Label: isoform X2
RefSeq Acc Id: XP_008002855   ⟸   XM_008004664
- Peptide Label: isoform X13
RefSeq Acc Id: XP_008002848   ⟸   XM_008004657
- Peptide Label: isoform X5
RefSeq Acc Id: XP_008002844   ⟸   XM_008004653
- Peptide Label: isoform X1
RefSeq Acc Id: XP_008002850   ⟸   XM_008004659
- Peptide Label: isoform X7
RefSeq Acc Id: XP_008002846   ⟸   XM_008004655
- Peptide Label: isoform X3
- UniProtKB: A0A0D9S392 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008002857   ⟸   XM_008004666
- Peptide Label: isoform X15
RefSeq Acc Id: XP_008002849   ⟸   XM_008004658
- Peptide Label: isoform X6
RefSeq Acc Id: XP_008002860   ⟸   XM_008004669
- Peptide Label: isoform X17
RefSeq Acc Id: XP_008002863   ⟸   XM_008004672
- Peptide Label: isoform X19
RefSeq Acc Id: ENSCSAP00000015331   ⟸   ENSCSAT00000000733
RefSeq Acc Id: XP_037852479   ⟸   XM_037996551
- Peptide Label: isoform X8
RefSeq Acc Id: XP_037852480   ⟸   XM_037996552
- Peptide Label: isoform X10
RefSeq Acc Id: XP_037852482   ⟸   XM_037996554
- Peptide Label: isoform X18


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000002715 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000000733.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.220.150 UniProtKB/TrEMBL
  1.20.5.170 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
  Nucleotidyltransferases domain 2 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  ARFGAP/RecO UniProtKB/TrEMBL
  ArfGAP_dom UniProtKB/TrEMBL
  ArfGAP_dom_sf UniProtKB/TrEMBL
  GIT-like UniProtKB/TrEMBL
  GIT1/2_CC UniProtKB/TrEMBL
  GIT1_C UniProtKB/TrEMBL
  GIT_SHD UniProtKB/TrEMBL
NCBI Gene GIT2 ENTREZGENE
PANTHER ARF GTPASE-ACTIVATING PROTEIN GIT2 UniProtKB/TrEMBL
  G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  ArfGap UniProtKB/TrEMBL
  GIT1_C UniProtKB/TrEMBL
  GIT_CC UniProtKB/TrEMBL
  GIT_SHD UniProtKB/TrEMBL
PRINTS REVINTRACTNG UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  ARFGAP UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  ArfGap UniProtKB/TrEMBL
  GIT UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
  SSF57863 UniProtKB/TrEMBL
UniProt A0A0D9S392 ENTREZGENE, UniProtKB/TrEMBL