EPS8L2 (EPS8 signaling adaptor L2) - Rat Genome Database

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Gene: EPS8L2 (EPS8 signaling adaptor L2) Chlorocebus sabaeus
Analyze
Symbol: EPS8L2
Name: EPS8 signaling adaptor L2 (Ensembl:EPS8 like 2)
RGD ID: 18561098
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN positive regulation of ruffle assembly (inferred); regulation of Rho protein signal transduction (inferred); Rho protein signal transduction (inferred); ASSOCIATED WITH autosomal recessive nonsyndromic deafness 106 (ortholog); Chanarin-Dorfman syndrome (ortholog); delta beta-thalassemia (ortholog); FOUND IN centrosome (inferred); cytosol (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: epidermal growth factor receptor kinase substrate 8-like protein 2; EPS8 like 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11523,811 - 540,781 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1523,524 - 540,803 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603897,583,092 - 97,603,117 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
EPS8L2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11523,811 - 540,781 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1523,524 - 540,803 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603897,583,092 - 97,603,117 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
EPS8L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811706,231 - 727,727 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11694,438 - 727,727 (+)EnsemblGRCh38hg38GRCh38
GRCh3711706,231 - 727,727 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611696,120 - 717,727 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411696,122 - 717,726NCBI
Celera11777,933 - 796,226 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef11522,663 - 544,755 (+)NCBIHuRef
CHM1_111705,039 - 726,667 (+)NCBICHM1_1
T2T-CHM13v2.011757,231 - 779,052 (+)NCBIT2T-CHM13v2.0
Eps8l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,918,824 - 140,942,933 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7140,918,793 - 140,942,933 (+)EnsemblGRCm39 Ensembl
GRCm387141,338,911 - 141,363,020 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,338,880 - 141,363,020 (+)EnsemblGRCm38mm10GRCm38
MGSCv377148,524,901 - 148,548,915 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,190,322 - 141,214,336 (+)NCBIMGSCv36mm8
Celera7141,132,780 - 141,156,774 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.66NCBI
Eps8l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,875,825 - 205,901,109 (+)NCBIGRCr8
mRatBN7.21196,446,260 - 196,471,544 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,446,287 - 196,471,541 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,791,599 - 204,816,875 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,918,487 - 211,943,577 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,592,625 - 204,617,711 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,327,992 - 214,353,466 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,328,071 - 214,353,461 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,245,105 - 221,270,580 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,539,214 - 201,560,761 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,690,190 - 201,715,474 (+)NCBI
Celera1194,083,674 - 194,105,278 (+)NCBICelera
Cytogenetic Map1q41NCBI
Eps8l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,372,571 - 11,389,804 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,371,928 - 11,390,588 (-)NCBIChiLan1.0ChiLan1.0
EPS8L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,100,061 - 3,121,158 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,312,578 - 2,333,709 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011720,528 - 741,623 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111765,685 - 787,128 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11765,689 - 787,128 (+)Ensemblpanpan1.1panPan2
EPS8L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11825,741,166 - 25,755,310 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1825,733,090 - 25,755,658 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1825,412,090 - 25,428,770 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01826,347,768 - 26,364,453 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1826,347,770 - 26,364,448 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11825,857,278 - 25,873,972 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,502,322 - 25,518,986 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01826,114,622 - 26,131,352 (+)NCBIUU_Cfam_GSD_1.0
Eps8l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947506,138 - 523,283 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936888506,138 - 523,302 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936888506,144 - 523,280 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPS8L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2433,649 - 452,630 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12435,257 - 452,630 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Eps8l2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476621,775,326 - 21,787,553 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476621,775,467 - 21,790,496 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 16 17
Low 20 20 43
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000008784   ⟹   ENSCSAP00000006920
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1523,524 - 540,803 (+)Ensembl
RefSeq Acc Id: XM_037998762   ⟹   XP_037854690
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603897,583,092 - 97,603,117 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037854690 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000006920.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000006920   ⟸   ENSCSAT00000008784
RefSeq Acc Id: XP_037854690   ⟸   XM_037998762
- UniProtKB: A0A0D9RE81 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010697 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008784.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro EPS8-like UniProtKB/TrEMBL
  EPS8_PTB UniProtKB/TrEMBL
  Eps8_SH3 UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PTB UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
  SAM_3 UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene EPS8L2 ENTREZGENE
PANTHER EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 2 UniProtKB/TrEMBL
  PTHR12287 UniProtKB/TrEMBL
Pfam PTB UniProtKB/TrEMBL
  SAM_3 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PROSITE PID UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART PTB UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt A0A0D9RE81 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-11-15 EPS8L2  EPS8 signaling adaptor L2  EPS8L2  EPS8 like 2  Symbol and/or name change 5135510 APPROVED