Eps8l2 (EPS8 signaling adaptor L2)

Gene: Eps8l2 (EPS8 signaling adaptor L2) Ictidomys tridecemlineatus

Analyze

Symbol:

Eps8l2

Name:

EPS8 signaling adaptor L2 (Ensembl:EPS8 like 2)

RGD ID:

12628727

Description:

ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN positive regulation of ruffle assembly (inferred); regulation of Rho protein signal transduction (inferred); Rho protein signal transduction (inferred); ASSOCIATED WITH autosomal recessive nonsyndromic deafness 106 (ortholog); Chanarin-Dorfman syndrome (ortholog); delta beta-thalassemia (ortholog); FOUND IN centrosome (inferred); cytosol (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

epidermal growth factor receptor kinase substrate 8-like protein 2; EPS8 like 2; EPS8 like 2, transcript variant X1; EPS8 like 2, transcript variant X2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EPS8L2 (EPS8 signaling adaptor L2)	NCBI	Ortholog
Mus musculus (house mouse):	Eps8l2 (EPS8-like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Eps8l2 (EPS8-like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Eps8l2 (EPS8 signaling adaptor L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EPS8L2 (EPS8 signaling adaptor L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EPS8L2 (EPS8 signaling adaptor L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EPS8L2 (EPS8 signaling adaptor L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EPS8L2 (EPS8 signaling adaptor L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Eps8l2 (EPS8 signaling adaptor L2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	506,138 - 523,283 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936888	506,138 - 523,302 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936888	506,144 - 523,280 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive nonsyndromic deafness 106 (ISO)

Chanarin-Dorfman syndrome (ISO)

delta beta-thalassemia (ISO)

developmental and epileptic encephalopathy (ISO)

early infantile epileptic encephalopathy (ISO)

immunodeficiency 39 (ISO)

neuronal ceroid lipofuscinosis (ISO)

Segawa Syndrome, Autosomal Recessive (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of ruffle assembly (IEA)

regulation of Rho protein signal transduction (IEA)

Rho protein signal transduction (IEA)

sensory perception of sound (IEA)

Cellular Component

centrosome (IEA)

cytosol (IEA)

plasma membrane (IEA)

protein-containing complex (IEA)

ruffle membrane (IEA)

stereocilium bundle (IEA)

stereocilium tip (IEA)

vesicle (IEA)

Molecular Function

actin binding (IEA)

guanyl-nucleotide exchange factor activity (IEA,ISO)

protein binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Eps8l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	506,138 - 523,283 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936888	506,138 - 523,302 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936888	506,144 - 523,280 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EPS8L2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	706,231 - 727,727 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	694,438 - 727,727 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	706,231 - 727,727 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	696,120 - 717,727 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	696,122 - 717,726	NCBI
Celera	11	777,933 - 796,226 (+)	NCBI		Celera
Cytogenetic Map	11	p15.5	NCBI
HuRef	11	522,663 - 544,755 (+)	NCBI		HuRef
CHM1_1	11	705,039 - 726,667 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	757,231 - 779,052 (+)	NCBI		T2T-CHM13v2.0

Eps8l2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	140,918,824 - 140,942,933 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	140,918,793 - 140,942,933 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	141,338,911 - 141,363,020 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	141,338,880 - 141,363,020 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	148,524,901 - 148,548,915 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	141,190,322 - 141,214,336 (+)	NCBI		MGSCv36	mm8
Celera	7	141,132,780 - 141,156,774 (+)	NCBI		Celera
Cytogenetic Map	7	F5	NCBI
cM Map	7	86.66	NCBI

Eps8l2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	205,875,825 - 205,901,109 (+)	NCBI		GRCr8
mRatBN7.2	1	196,446,260 - 196,471,544 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	196,446,287 - 196,471,541 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	204,791,599 - 204,816,875 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	211,918,487 - 211,943,577 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	204,592,625 - 204,617,711 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	214,327,992 - 214,353,466 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	214,328,071 - 214,353,461 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	221,245,105 - 221,270,580 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	201,539,214 - 201,560,761 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	201,690,190 - 201,715,474 (+)	NCBI
Celera	1	194,083,674 - 194,105,278 (+)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI

Eps8l2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955476	11,372,571 - 11,389,804 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955476	11,371,928 - 11,390,588 (-)	NCBI	ChiLan1.0	ChiLan1.0

EPS8L2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	3,100,061 - 3,121,158 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	2,312,578 - 2,333,709 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	720,528 - 741,623 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	765,685 - 787,128 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	765,689 - 787,128 (+)	Ensembl	panpan1.1		panPan2

EPS8L2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	25,741,166 - 25,755,310 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	25,733,090 - 25,755,658 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	25,412,090 - 25,428,770 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	26,347,768 - 26,364,453 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	26,347,770 - 26,364,448 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	25,857,278 - 25,873,972 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	25,502,322 - 25,518,986 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	26,114,622 - 26,131,352 (+)	NCBI		UU_Cfam_GSD_1.0

EPS8L2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	433,649 - 452,630 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	435,257 - 452,630 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

EPS8L2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	523,811 - 540,781 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	523,524 - 540,803 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	97,583,092 - 97,603,117 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Eps8l2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624766	21,775,326 - 21,787,553 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624766	21,775,467 - 21,790,496 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005341623	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013365856	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040283896	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040283897	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040283898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000013857 ⟹ ENSSTOP00000012415

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936888	509,028 - 522,554 (+)	Ensembl

RefSeq Acc Id:

ENSSTOT00000041567 ⟹ ENSSTOP00000026698

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936888	506,138 - 523,302 (+)	Ensembl

RefSeq Acc Id:

XM_005341623 ⟹ XP_005341680

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	506,138 - 523,283 (+)	NCBI
SpeTri2.0	NW_004936888	506,144 - 523,280 (+)	NCBI

Sequence:

show sequence

CGACCCGCCCGCCAGCGGAGACCTAGTGCGGTGGCCAAGGCGCGGACAGACTGGCGGACACACG
GACGGGGGACTGGCCACAGCGAGGACGCAGTTGCCGCGAGCAGGTGTGGGCCAGGCATTGAGTT
CTGCCCTCCCAGCTGCGGGCCGCCACCAAGGACACCATGAGCCAGTCAGGAGCCATGAGCTGCT
GCCCTGGTGCTGCCAATGGCAGCCTGGGCCGGTCCGATGGTGTGGCTAAGATGAGCGCGAAGGA
TCTGTTTGAGCAGAGGAAGAAGTACTCCAACTCCAATGTCATCATGCACGAGACCTCCCAGTAC
CATGTCCAGCACTTGGCCACATTCATCATGGACAAGAGCGAGGCCATCACATCTGTGGACGACG
CCATCCGGAAGCTGGTGCAGCTCAGTGCCAAGGAGAAGGTCTGGGCGCAGGAGGTGCTGCTGCA
GGTGGACGACAAGGCCCTGCGGCTGCTGGACGTTGAGAACCAGGAAGAGCTGGAGAACTTCCCG
CTGCCCACCGTGCTGCGCAGCCAGACGGTGCTGAACCAGCTGCGCTACCCCTCGGTGCTGCTGC
TGGTGTGCCAGGACTCGGAGCAGAGCCGGCCCGACGTGCACTTCTTCCACTGCGACGAGGTGGA
GGCGGAGCTGGTGCAGGAGGACATCCAGAGCGCGCTGGCCGACTGCCGGATGGGGAAGAAGTTG
CGGCCACAGACCCTGAAGGGGCACCAGGAGAAGATCCGGCAGCGGCAGTCCATCCTGCCGCCTC
CCCAGAGCCCAGCTCCCATCCCCTTTCAGCGCCAGGCTGGGGACTCTCCTCAGGCCAAGAACCG
CGTGGGCCTGCCAGCACCCGTCACAGAGCCAGGCTACCGCCGCCGGGAATCGCAGGATGAGGAG
CCTCGGGCGGTGCTGGCTCAGAGGATAGAGAAGGAGACGCAAATCCTCAACTGCGCCCTGGATG
ACATCGAGTGGTTCGTGGCCCGGCTACAGAAGGCGGCCGAGGCCTTCAAGCAGCTGAACCAGCG
GAAGAAAGGGAAGAAGAAGGGCAAGAAGGGGCCGGCAGAGGGTGTCCTCACGCTGCGTGCCCGG
CCCCCCTCTGAGGGTGAGTTTGTCGACTGTTTCCAGAAAACCAAGCTGGCCATCAATCTGCTGG
CCAAGCTGCAGAAGCACATCCAGAACCCCAGTGCGGCTGAGCTGGTGCACTTCCTCTTCGGGCC
TCTGGACCTGATCGTCAACACCTGCGGAGGCCCAGACATGGCACGCTCCGTCTTCAGCCCGCTG
CTGTCCCAGGAGGCTGTGGCCTTCCTACGTGGCCACCTGGTCCCAAAGGAGATGTCACTGTGGG
AGTCCCTGGGGGACACCTGGACCCGGCCCCGCTCTGAGTGGCCGAAGGAGCCACAGGTGCCCCT
GTACGTGCCCAAGTTCCACAGTGGCTGGGAACCGCCTCTGGATGTGCTGCAGGAGGCTCCCTGG
GAGATGGAAGGACTGGCCTCTGGCCCCGATGACCAGCCCACCCCTGTGAGCCGACTCTCCATAA
GAAACTCCCCGAAACACAGTCTCTCCTCTGAGTCCACACCCCAGGGGGACGTCTTCCCACCAGT
CAGCTCCCCACATTCTCACAGGGGCCACCAGCCAACATCAGCCCCGGCCAAGTACGTGAAGATT
CTCTACGACTTCACAGCCCGCAATGCCAACGAGCTGTCGGTGCTCAAGGATGAGGTCCTAGAGG
TCCTGGAGGATGGCCGGCAGTGGTGGAAGCTTCGCAGCCGAAGTGGCCAGTCTGGCTATGTGCC
CTGCAACATCCTGGATGAGGTTCGGCCAGAGGACATTGGTGCCCCCCTGGAGCAGGCCAGCCAG
AAATACTGGGGTCCCGCCAGCCCGATGCATAAACTGCCCCCTATCTTCGCAGGGAACAAAGATG
AGCTGATCCACCACATGGATGAAGTCAACGATGAGCTCATGAAGAAAATTAGCCACATCAAGGC
ACAGCCGCAGAGGCACTTCCGCGTGGAGCGCACCCAGCCAGTGCACCTGCCACTCACCTTTGAG
TCCGGCCCGGATGAAGTCCGGGCCTGGCTAGAAGCCAAGGCCTTCAGCGGCCGGATCGTGGAGA
ACCTGGGTATCCTGACCGGACCCCAGCTCTTCTCCCTCAACAAAGATGAGCTGAAGAGGGTGTG
CGGGGAGGAGGGCATCCGCGTGTACAGCCAACTCACAGTGCAGAAGGCGATGCTGGAGAAGCAG
CAAAGTGGGTCGGAGTTGGAAGAACTCATGAACAAGTTTCATTCCAAGAACCAGAGGAGGGTGG
AGGACAGCTAGACCTGGTGGACTGTTGCCACCCTTGCTGCAGAGGGAGGCAGCACGGGTGGTGG
GCCCGCTCCCAGTGCACGGAGTATTATTTTATATGTGTATTATTTTATACTGAGGACTCACATG
GGCTGGATGGGGTGCTCATCTGCCTCTAGGCGGTTGGCTTATCTTCAGGCTGGGCCAGGCCCAT
GGATGGCCTCTCAGCTGCAAGCCACTCACCCACCCAAACCAAGGCCTCTCCCAGCCAAACCTGC
CACCTAGCAGTGCCAGCCTCCATCCATCAGCCCTAGGCCACAGGACCCCCCAGGTGGGCAGGGC
CTCTCTGGCCTCCCTGTGCTGATGTCGGCTCCTGGCCTCTGGAGTTTGACACTCACCACCTGCT
GCTTGATTTCATATGCACCTGCTCCCAGCTGTTCCCACCTGTCTCAGGTGGGCCAGAGCTCCAG
GCTGCTTAGGCTGGTGACCTGGACTCCAGGTTTGTCCCCCACAGGATGCTGTCCCCAAAAAATG
GCCTGCAGGGGCTCCAGGACAGGAAGCCACAGTTGCCCCACCGGTTAGGGGCATGCTGTGCCCT
CACCCTTTCAAAGACCAAGGCGCGAGGGCTGTAGACACCCACTCCCATCCAGCAGAGCCCAGAC
AGGAACTTTCTCTGACCACATCTCAGGCCAGCTAAGCACTGCACGCTGGTGACTGGTGATCTTA
GAGCCCTGGGCAGAGCCTCACATCCAGAAATGAGGGTGGGGGCTCTAAGGCCACATTATTAAAC
CAGTTTCTCCTGGAAG

hide sequence

RefSeq Acc Id:

XM_040283896 ⟹ XP_040139830

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	508,981 - 523,283 (+)	NCBI

RefSeq Acc Id:

XM_040283897 ⟹ XP_040139831

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	508,981 - 523,283 (+)	NCBI

RefSeq Acc Id:

XM_040283898 ⟹ XP_040139832

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	506,138 - 523,283 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005341680	(Get FASTA)	NCBI Sequence Viewer
	XP_040139830	(Get FASTA)	NCBI Sequence Viewer
	XP_040139831	(Get FASTA)	NCBI Sequence Viewer
	XP_040139832	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000012415.3
	ENSSTOP00000026698.1
GenBank Protein	KAG3284320	(Get FASTA)	NCBI Sequence Viewer
	KAG3284321	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005341680 ⟸ XM_005341623
- Peptide Label:	isoform X4
- UniProtKB:	A0A287CZJ1 (UniProtKB/TrEMBL), I3MLT7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSQSGAMSCCPGAANGSLGRSDGVAKMSAKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDK SEAITSVDDAIRKLVQLSAKEKVWAQEVLLQVDDKALRLLDVENQEELENFPLPTVLRSQTVLN QLRYPSVLLLVCQDSEQSRPDVHFFHCDEVEAELVQEDIQSALADCRMGKKLRPQTLKGHQEKI RQRQSILPPPQSPAPIPFQRQAGDSPQAKNRVGLPAPVTEPGYRRRESQDEEPRAVLAQRIEKE TQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKGPAEGVLTLRARPPSEGEFVDCFQ KTKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCGGPDMARSVFSPLLSQEAVAFLRGH LVPKEMSLWESLGDTWTRPRSEWPKEPQVPLYVPKFHSGWEPPLDVLQEAPWEMEGLASGPDDQ PTPVSRLSIRNSPKHSLSSESTPQGDVFPPVSSPHSHRGHQPTSAPAKYVKILYDFTARNANEL SVLKDEVLEVLEDGRQWWKLRSRSGQSGYVPCNILDEVRPEDIGAPLEQASQKYWGPASPMHKL PPIFAGNKDELIHHMDEVNDELMKKISHIKAQPQRHFRVERTQPVHLPLTFESGPDEVRAWLEA KAFSGRIVENLGILTGPQLFSLNKDELKRVCGEEGIRVYSQLTVQKAMLEKQQSGSELEELMNK FHSKNQRRVEDS hide sequence

RefSeq Acc Id:	XP_040139832 ⟸ XM_040283898
- Peptide Label:	isoform X3
- UniProtKB:	I3MLT7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_040139830 ⟸ XM_040283896
- Peptide Label:	isoform X1
- UniProtKB:	I3MLT7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_040139831 ⟸ XM_040283897
- Peptide Label:	isoform X2
- UniProtKB:	I3MLT7 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSSTOP00000012415 ⟸ ENSSTOT00000013857

RefSeq Acc Id:

ENSSTOP00000026698 ⟸ ENSSTOT00000041567

Protein Domains

SH3

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000013842	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000013857.3	UniProtKB/TrEMBL
	ENSSTOT00000041567.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.150.50	UniProtKB/TrEMBL
	2.30.29.30	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
InterPro	EPS8-like	UniProtKB/TrEMBL
	EPS8_PTB	UniProtKB/TrEMBL
	Eps8_SH3	UniProtKB/TrEMBL
	PH-like_dom_sf	UniProtKB/TrEMBL
	PTB	UniProtKB/TrEMBL
	PTB/PI_dom	UniProtKB/TrEMBL
	SAM/pointed_sf	UniProtKB/TrEMBL
	SAM_3	UniProtKB/TrEMBL
	SH3-like_dom_sf	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
NCBI Gene	Eps8l2	ENTREZGENE
PANTHER	EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 2	UniProtKB/TrEMBL
	PTHR12287	UniProtKB/TrEMBL
Pfam	PTB	UniProtKB/TrEMBL
	SAM_3	UniProtKB/TrEMBL
	SH3_1	UniProtKB/TrEMBL
PROSITE	SH3	UniProtKB/TrEMBL
SMART	PTB	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/TrEMBL
	SSF50044	UniProtKB/TrEMBL
UniProt	A0A287CZJ1	ENTREZGENE, UniProtKB/TrEMBL
	I3MLT7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-11-15	Eps8l2	EPS8 signaling adaptor L2	Eps8l2	EPS8 like 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM