SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2) - Rat Genome Database

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Gene: SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2) Chlorocebus sabaeus
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Symbol: SRGAP2
Name: SLIT-ROBO Rho GTPase activating protein 2
RGD ID: 18548042
Description: ENCODES a protein that exhibits GTPase activator activity (ortholog); identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN actin filament severing (ortholog); dendritic spine development (ortholog); excitatory synapse assembly (ortholog); ASSOCIATED WITH autistic disorder (ortholog); familial adult myoclonic epilepsy 5 (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN cytosol (ortholog); dendritic spine (ortholog); dendritic spine head (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: SLIT-ROBO Rho GTPase-activating protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12522,897,699 - 23,147,097 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2522,897,469 - 23,145,218 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605523,596,464 - 23,848,743 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SRGAP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12522,897,699 - 23,147,097 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2522,897,469 - 23,145,218 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605523,596,464 - 23,848,743 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SRGAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381206,203,541 - 206,464,436 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1206,203,346 - 206,464,436 (+)EnsemblGRCh38hg38GRCh38
GRCh371206,516,197 - 206,637,776 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361204,582,823 - 204,704,406 (+)NCBINCBI36Build 36hg18NCBI36
Celera1179,840,685 - 179,889,229 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1177,269,281 - 177,336,031 (+)NCBIHuRef
CHM1_11207,651,212 - 207,909,982 (+)NCBICHM1_1
T2T-CHM13v2.01205,467,727 - 205,728,612 (+)NCBIT2T-CHM13v2.0
Srgap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391131,212,989 - 131,455,269 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1131,212,989 - 131,455,090 (-)EnsemblGRCm39 Ensembl
GRCm381131,285,251 - 131,527,531 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1131,285,251 - 131,527,352 (-)EnsemblGRCm38mm10GRCm38
MGSCv371133,181,828 - 133,423,938 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361133,112,797 - 133,354,907 (-)NCBIMGSCv36mm8
Celera1133,908,005 - 134,139,712 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.93NCBI
Srgap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81345,298,192 - 45,519,330 (-)NCBIGRCr8
mRatBN7.21342,745,956 - 42,967,091 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,745,947 - 42,967,058 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1345,354,029 - 45,577,291 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,642,156 - 46,865,413 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,905,845 - 44,129,315 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01348,065,280 - 48,286,888 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1348,068,158 - 48,286,720 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01353,141,198 - 53,362,657 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41344,239,946 - 44,452,446 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1343,100,229 - 43,312,451 (-)NCBICelera
Cytogenetic Map13q13NCBI
Srgap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540641,801,235 - 42,050,731 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540641,801,235 - 42,050,731 (+)NCBIChiLan1.0ChiLan1.0
SRGAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2142,913,844 - 43,168,344 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1142,879,341 - 43,133,846 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01181,808,318 - 182,064,583 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11186,090,389 - 186,346,012 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1186,092,113 - 186,346,019 (+)Ensemblpanpan1.1panPan2
SRGAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1382,506,617 - 2,741,866 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha382,599,173 - 2,834,184 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0382,504,091 - 2,739,418 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl382,504,099 - 2,739,408 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1382,497,737 - 2,732,688 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0382,890,316 - 3,126,035 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0383,090,840 - 3,326,253 (+)NCBIUU_Cfam_GSD_1.0
Srgap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934468,855,976 - 69,097,751 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365576,096,258 - 6,338,024 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRGAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl966,838,123 - 67,117,315 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1966,838,062 - 67,117,315 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2973,085,753 - 73,361,203 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Srgap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248074,935,472 - 5,169,050 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248074,937,573 - 5,169,104 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 27 54
Low 9 20 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000012996   ⟹   ENSCSAP00000011012
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2522,897,469 - 23,145,218 (-)Ensembl
RefSeq Acc Id: XM_007988687   ⟹   XP_007986878
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12522,897,699 - 23,147,097 (-)NCBI
Vero_WHO_p1.0NW_02366605523,596,464 - 23,846,716 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988688   ⟹   XP_007986879
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12522,897,699 - 23,145,976 (-)NCBI
Vero_WHO_p1.0NW_02366605523,596,464 - 23,846,090 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988689   ⟹   XP_007986880
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12522,897,699 - 23,147,097 (-)NCBI
Vero_WHO_p1.0NW_02366605523,596,464 - 23,846,716 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988690   ⟹   XP_007986881
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12522,900,632 - 23,053,729 (-)NCBI
Vero_WHO_p1.0NW_02366605523,596,464 - 23,752,282 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988691   ⟹   XP_007986882
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12522,901,003 - 23,147,097 (-)NCBI
Vero_WHO_p1.0NW_02366605523,596,464 - 23,848,743 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988692   ⟹   XP_007986883
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12522,907,505 - 23,147,095 (-)NCBI
Vero_WHO_p1.0NW_02366605523,604,881 - 23,846,716 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007988693   ⟹   XP_007986884
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12522,907,505 - 23,147,096 (-)NCBI
Vero_WHO_p1.0NW_02366605523,604,881 - 23,846,716 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037985631   ⟹   XP_037841559
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605523,604,881 - 23,846,716 (-)NCBI
RefSeq Acc Id: XM_037985632   ⟹   XP_037841560
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605523,604,881 - 23,846,716 (-)NCBI
RefSeq Acc Id: XM_037985633   ⟹   XP_037841561
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605523,604,881 - 23,846,716 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_007986880   ⟸   XM_007988689
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007986878   ⟸   XM_007988687
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RQX3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007986879   ⟸   XM_007988688
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RQX3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007986881   ⟸   XM_007988690
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007986882   ⟸   XM_007988691
- Peptide Label: isoform X4
RefSeq Acc Id: XP_007986884   ⟸   XM_007988693
- Peptide Label: isoform X9
RefSeq Acc Id: XP_007986883   ⟸   XM_007988692
- Peptide Label: isoform X8
RefSeq Acc Id: ENSCSAP00000011012   ⟸   ENSCSAT00000012996
RefSeq Acc Id: XP_037841561   ⟸   XM_037985633
- Peptide Label: isoform X7
RefSeq Acc Id: XP_037841559   ⟸   XM_037985631
- Peptide Label: isoform X5
RefSeq Acc Id: XP_037841560   ⟸   XM_037985632
- Peptide Label: isoform X6


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000014903 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000012996.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  1.20.1270.60 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/TrEMBL
  F_BAR UniProtKB/TrEMBL
  FCH_dom UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  srGAP1/2/3_SH3 UniProtKB/TrEMBL
KEGG Report csab:103230200 UniProtKB/TrEMBL
NCBI Gene SRGAP2 ENTREZGENE
PANTHER PTHR14166:SF6 UniProtKB/TrEMBL
  SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN UniProtKB/TrEMBL
Pfam FCH UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PROSITE F_BAR UniProtKB/TrEMBL
  RHOGAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART FCH UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/TrEMBL
  SSF48350 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt A0A0D9RQX3 ENTREZGENE, UniProtKB/TrEMBL