SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2) - Rat Genome Database

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Gene: SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2) Pan paniscus
Analyze
Symbol: SRGAP2
Name: SLIT-ROBO Rho GTPase activating protein 2
RGD ID: 11840583
Description: ENCODES a protein that exhibits GTPase activator activity (inferred); identical protein binding (inferred); protein homodimerization activity (inferred); INVOLVED IN regulation of synapse assembly (ortholog); ASSOCIATED WITH autistic disorder (ortholog); familial adult myoclonic epilepsy 5 (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN dendritic spine (ortholog); glutamatergic synapse (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: SLIT-ROBO Rho GTPase-activating protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2142,913,844 - 43,168,344 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1142,879,341 - 43,133,846 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01181,808,318 - 182,064,583 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11186,090,389 - 186,346,012 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1186,092,113 - 186,346,019 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SRGAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2142,913,844 - 43,168,344 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1142,879,341 - 43,133,846 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01181,808,318 - 182,064,583 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11186,090,389 - 186,346,012 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1186,092,113 - 186,346,019 (+)Ensemblpanpan1.1panPan2
SRGAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381206,203,541 - 206,464,436 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1206,203,346 - 206,464,436 (+)EnsemblGRCh38hg38GRCh38
GRCh371206,516,197 - 206,637,776 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361204,582,823 - 204,704,406 (+)NCBINCBI36Build 36hg18NCBI36
Celera1179,840,685 - 179,889,229 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1177,269,281 - 177,336,031 (+)NCBIHuRef
CHM1_11207,651,212 - 207,909,982 (+)NCBICHM1_1
T2T-CHM13v2.01205,467,727 - 205,728,612 (+)NCBIT2T-CHM13v2.0
Srgap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391131,212,989 - 131,455,269 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1131,212,989 - 131,455,090 (-)EnsemblGRCm39 Ensembl
GRCm381131,285,251 - 131,527,531 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1131,285,251 - 131,527,352 (-)EnsemblGRCm38mm10GRCm38
MGSCv371133,181,828 - 133,423,938 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361133,112,797 - 133,354,907 (-)NCBIMGSCv36mm8
Celera1133,908,005 - 134,139,712 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.93NCBI
Srgap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81345,298,192 - 45,519,330 (-)NCBIGRCr8
mRatBN7.21342,745,956 - 42,967,091 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,745,947 - 42,967,058 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1345,354,029 - 45,577,291 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,642,156 - 46,865,413 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,905,845 - 44,129,315 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01348,065,280 - 48,286,888 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1348,068,158 - 48,286,720 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01353,141,198 - 53,362,657 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41344,239,946 - 44,452,446 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1343,100,229 - 43,312,451 (-)NCBICelera
Cytogenetic Map13q13NCBI
Srgap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540641,801,235 - 42,050,731 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540641,801,235 - 42,050,731 (+)NCBIChiLan1.0ChiLan1.0
SRGAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1382,506,617 - 2,741,866 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha382,599,173 - 2,834,184 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0382,504,091 - 2,739,418 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl382,504,099 - 2,739,408 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1382,497,737 - 2,732,688 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0382,890,316 - 3,126,035 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0383,090,840 - 3,326,253 (+)NCBIUU_Cfam_GSD_1.0
Srgap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934468,855,976 - 69,097,751 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365576,096,258 - 6,338,024 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRGAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl966,838,123 - 67,117,315 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1966,838,062 - 67,117,315 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2973,085,753 - 73,361,203 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRGAP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12522,897,699 - 23,147,097 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2522,897,469 - 23,145,218 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605523,596,464 - 23,848,743 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srgap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248074,935,472 - 5,169,050 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248074,937,573 - 5,169,104 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000058470   ⟹   ENSPPAP00000035581
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1186,092,113 - 186,346,019 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000058497   ⟹   ENSPPAP00000035608
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1186,094,616 - 186,343,006 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000058501   ⟹   ENSPPAP00000035612
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1186,094,616 - 186,341,273 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000058515   ⟹   ENSPPAP00000035626
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1186,271,890 - 186,287,688 (+)Ensembl
RefSeq Acc Id: XM_003822926   ⟹   XP_003822974
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2142,913,844 - 43,168,336 (-)NCBI
NHGRI_mPanPan1142,879,341 - 43,133,846 (-)NCBI
Mhudiblu_PPA_v01181,810,074 - 182,064,576 (+)NCBI
PanPan1.11186,092,113 - 186,346,012 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008976531   ⟹   XP_008974779
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2142,913,844 - 43,168,332 (-)NCBI
NHGRI_mPanPan1142,879,341 - 43,133,846 (-)NCBI
Mhudiblu_PPA_v01181,810,074 - 182,064,576 (+)NCBI
PanPan1.11186,092,113 - 186,346,012 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008976532   ⟹   XP_008974780
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2142,922,094 - 43,168,344 (-)NCBI
NHGRI_mPanPan1142,887,592 - 43,133,846 (-)NCBI
Mhudiblu_PPA_v01181,810,075 - 182,056,324 (+)NCBI
PanPan1.11186,092,113 - 186,337,761 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008976533   ⟹   XP_008974781
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2142,922,094 - 43,168,332 (-)NCBI
NHGRI_mPanPan1142,887,592 - 43,133,846 (-)NCBI
Mhudiblu_PPA_v01181,810,075 - 182,056,324 (+)NCBI
PanPan1.11186,092,113 - 186,337,761 (+)NCBI
Sequence:
RefSeq Acc Id: XM_014342520   ⟹   XP_014198006
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2142,922,094 - 43,168,336 (-)NCBI
NHGRI_mPanPan1142,887,592 - 43,133,846 (-)NCBI
Mhudiblu_PPA_v01181,810,075 - 182,056,324 (+)NCBI
PanPan1.11186,092,113 - 186,337,761 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024927499   ⟹   XP_024783267
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2142,917,095 - 43,168,336 (-)NCBI
NHGRI_mPanPan1142,882,593 - 43,133,846 (-)NCBI
Mhudiblu_PPA_v01181,808,318 - 182,064,583 (+)NCBI
PanPan1.11186,090,389 - 186,346,012 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034945318   ⟹   XP_034801209
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2142,922,094 - 43,168,332 (-)NCBI
NHGRI_mPanPan1142,887,592 - 43,133,846 (-)NCBI
Mhudiblu_PPA_v01181,810,075 - 182,056,324 (+)NCBI
RefSeq Acc Id: XM_055108940   ⟹   XP_054964915
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2142,919,639 - 43,168,336 (-)NCBI
NHGRI_mPanPan1142,885,138 - 43,133,846 (-)NCBI
RefSeq Acc Id: XM_055108944   ⟹   XP_054964919
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2142,919,639 - 43,168,332 (-)NCBI
NHGRI_mPanPan1142,885,137 - 43,133,846 (-)NCBI
RefSeq Acc Id: XM_063599687   ⟹   XP_063455757
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2142,913,844 - 43,167,259 (-)NCBI
RefSeq Acc Id: XM_063599795   ⟹   XP_063455865
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2142,922,094 - 43,167,259 (-)NCBI
RefSeq Acc Id: XM_063599830   ⟹   XP_063455900
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2142,922,094 - 43,168,335 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003822974   ⟸   XM_003822926
- Peptide Label: isoform X1
- UniProtKB: A0A2R9C1H1 (UniProtKB/TrEMBL),   A0A2R9C117 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008974779   ⟸   XM_008976531
- Peptide Label: isoform X2
- UniProtKB: A0A2R9C117 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008974780   ⟸   XM_008976532
- Peptide Label: isoform X9
- UniProtKB: A0A2R9C1J8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_014198006   ⟸   XM_014342520
- Peptide Label: isoform X6
- UniProtKB: A0A2R9C1J8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008974781   ⟸   XM_008976533
- Peptide Label: isoform X10
- UniProtKB: A0A2R9C1J8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024783267   ⟸   XM_024927499
- Peptide Label: isoform X3
- UniProtKB: A0A2R9C1J8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034801209   ⟸   XM_034945318
- Peptide Label: isoform X7
- UniProtKB: A0A2R9C1J8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000035608   ⟸   ENSPPAT00000058497
RefSeq Acc Id: ENSPPAP00000035581   ⟸   ENSPPAT00000058470
RefSeq Acc Id: ENSPPAP00000035612   ⟸   ENSPPAT00000058501
RefSeq Acc Id: ENSPPAP00000035626   ⟸   ENSPPAT00000058515
RefSeq Acc Id: XP_054964919   ⟸   XM_055108944
- Peptide Label: isoform X5
RefSeq Acc Id: XP_054964915   ⟸   XM_055108940
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063455757   ⟸   XM_063599687
- Peptide Label: isoform X1
- UniProtKB: A0A2R9C1H1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063455900   ⟸   XM_063599830
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063455865   ⟸   XM_063599795
- Peptide Label: isoform X6
Protein Domains
F-BAR   Rho-GAP   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000040467 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000058470.1 UniProtKB/TrEMBL
  ENSPPAT00000058497.1 UniProtKB/TrEMBL
  ENSPPAT00000058501.1 UniProtKB/TrEMBL
  ENSPPAT00000058515.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  1.20.1270.60 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/TrEMBL
  F_BAR UniProtKB/TrEMBL
  FCH_dom UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  srGAP1/2/3_SH3 UniProtKB/TrEMBL
KEGG Report pps:100993145 UniProtKB/TrEMBL
NCBI Gene SRGAP2 ENTREZGENE
PANTHER PTHR14166:SF6 UniProtKB/TrEMBL
  SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN UniProtKB/TrEMBL
Pfam FCH UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PROSITE F_BAR UniProtKB/TrEMBL
  RHOGAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART FCH UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/TrEMBL
  SSF48350 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt A0A2R9C117 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9C1H1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9C1J8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9C443_PANPA UniProtKB/TrEMBL