SPTB (spectrin beta, erythrocytic) - Rat Genome Database

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Gene: SPTB (spectrin beta, erythrocytic) Chlorocebus sabaeus
Analyze
Symbol: SPTB
Name: spectrin beta, erythrocytic
RGD ID: 18526683
Description: ENCODES a protein that exhibits ankyrin binding (ortholog); INVOLVED IN hemopoiesis (ortholog); modification of postsynaptic actin cytoskeleton (ortholog); plasma membrane organization (ortholog); ASSOCIATED WITH congenital hemolytic anemia (ortholog); Elliptocytosis 3 (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog); cortical cytoskeleton (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: spectrin beta chain, erythrocytic
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12441,957,438 - 42,038,522 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2441,978,595 - 42,038,516 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605330,129,480 - 30,266,419 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SPTB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12441,957,438 - 42,038,522 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2441,978,595 - 42,038,516 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605330,129,480 - 30,266,419 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SPTB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381464,746,283 - 64,879,907 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1464,746,283 - 64,879,907 (-)EnsemblGRCh38hg38GRCh38
GRCh371465,213,001 - 65,346,625 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361464,282,754 - 64,359,619 (-)NCBINCBI36Build 36hg18NCBI36
Build 341464,302,870 - 64,416,308NCBI
Celera1445,270,736 - 45,347,605 (-)NCBICelera
Cytogenetic Map14q23.3NCBI
HuRef1445,384,969 - 45,462,806 (-)NCBIHuRef
CHM1_11465,152,596 - 65,229,440 (-)NCBICHM1_1
T2T-CHM13v2.01458,954,121 - 59,087,910 (-)NCBIT2T-CHM13v2.0
Sptb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391276,627,262 - 76,757,321 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1276,627,262 - 76,757,321 (-)EnsemblGRCm39 Ensembl
GRCm381276,580,488 - 76,710,547 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1276,580,488 - 76,710,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv371277,681,475 - 77,811,534 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361277,499,328 - 77,629,387 (-)NCBIMGSCv36mm8
Celera1277,672,725 - 77,802,629 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.73NCBI
Sptb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86101,043,512 - 101,170,389 (-)NCBIGRCr8
mRatBN7.2695,310,342 - 95,437,221 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl695,310,326 - 95,437,118 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx695,718,916 - 95,828,078 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0696,017,424 - 96,126,588 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0695,446,242 - 95,555,412 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0699,657,144 - 99,783,189 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,659,651 - 99,783,047 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06109,055,163 - 109,181,316 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4699,194,202 - 99,315,691 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1699,197,658 - 99,319,147 (-)NCBI
Celera693,748,706 - 93,857,362 (-)NCBICelera
Cytogenetic Map6q24NCBI
Sptb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554665,097,116 - 5,167,596 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554665,013,963 - 5,170,186 (+)NCBIChiLan1.0ChiLan1.0
SPTB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21565,860,082 - 65,997,182 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11465,076,595 - 65,213,602 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01445,329,658 - 45,466,597 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11464,209,453 - 64,289,073 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1464,209,453 - 64,288,851 (-)Ensemblpanpan1.1panPan2
SPTB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1839,156,388 - 39,300,908 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl839,158,795 - 39,221,193 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha838,861,964 - 38,913,675 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0839,377,314 - 39,523,986 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl839,379,542 - 39,500,041 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1839,013,953 - 39,065,557 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0839,086,903 - 39,138,647 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0839,445,769 - 39,497,441 (-)NCBIUU_Cfam_GSD_1.0
Sptb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864065,651,095 - 65,775,749 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364958,415,912 - 8,486,039 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364958,415,950 - 8,540,590 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPTB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl788,812,718 - 88,954,306 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1788,812,717 - 88,954,471 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2795,193,318 - 95,335,373 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sptb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473436,202,011 - 36,270,942 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473436,151,701 - 36,272,058 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 15 8 55
Low 19 12 5
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000011558   ⟹   ENSCSAP00000009625
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2441,978,595 - 42,038,516 (-)Ensembl
RefSeq Acc Id: XM_037984121   ⟹   XP_037840049
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605330,129,480 - 30,266,419 (-)NCBI
RefSeq Acc Id: XM_037984122   ⟹   XP_037840050
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605330,129,480 - 30,248,075 (-)NCBI
RefSeq Acc Id: XM_037984123   ⟹   XP_037840051
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605330,129,480 - 30,181,101 (-)NCBI
RefSeq Acc Id: XR_005235402
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605330,129,480 - 30,266,419 (-)NCBI
Protein Sequences
Protein RefSeqs XP_037840049 (Get FASTA)   NCBI Sequence Viewer  
  XP_037840050 (Get FASTA)   NCBI Sequence Viewer  
  XP_037840051 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009625.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000009625   ⟸   ENSCSAT00000011558
RefSeq Acc Id: XP_037840049   ⟸   XM_037984121
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RLY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037840050   ⟸   XM_037984122
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RLY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037840051   ⟸   XM_037984123
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013664 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011558.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.58.60 UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/TrEMBL
  Spectrin_bsu UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/TrEMBL
NCBI Gene SPTB ENTREZGENE
PANTHER SPECTRIN BETA CHAIN, ERYTHROCYTIC UniProtKB/TrEMBL
  SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN UniProtKB/TrEMBL
Pfam PF00307 UniProtKB/TrEMBL
  Spectrin UniProtKB/TrEMBL
PIRSF Spectrin_beta_subunit UniProtKB/TrEMBL
PROSITE ACTININ_1 UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
SMART SM00033 UniProtKB/TrEMBL
  SPEC UniProtKB/TrEMBL
Superfamily-SCOP Spectrin repeat UniProtKB/TrEMBL
  SSF47576 UniProtKB/TrEMBL
UniProt A0A0D9RLY6 ENTREZGENE, UniProtKB/TrEMBL