Sptb (spectrin, beta, erythrocytic) - Rat Genome Database

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Gene: Sptb (spectrin, beta, erythrocytic) Rattus norvegicus
Analyze
Symbol: Sptb
Name: spectrin, beta, erythrocytic
RGD ID: 1303243
Description: Predicted to enable actin filament binding activity and ankyrin binding activity. Predicted to be involved in actin cytoskeleton organization and modification of postsynaptic actin cytoskeleton. Predicted to act upstream of or within hemopoiesis; plasma membrane organization; and porphyrin-containing compound biosynthetic process. Is active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in hereditary spherocytosis and hereditary spherocytosis type 2. Orthologous to human SPTB (spectrin beta, erythrocytic); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: erythroid spectrin beta; hypothetical protein LOC679700; LOC314251; LOC679700; spectrin beta 1; spectrin beta chain, erythrocyte; spectrin beta chain, erythrocytic; Spnb1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86101,043,512 - 101,170,389 (-)NCBIGRCr8
mRatBN7.2695,310,342 - 95,437,221 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl695,310,326 - 95,437,118 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx695,718,916 - 95,828,078 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0696,017,424 - 96,126,588 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0695,446,242 - 95,555,412 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0699,657,144 - 99,783,189 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,659,651 - 99,783,047 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06109,055,163 - 109,181,316 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4699,194,202 - 99,315,691 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1699,197,658 - 99,319,147 (-)NCBI
Celera693,748,706 - 93,857,362 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Spectrin Rouen (beta 220-218), a novel shortened beta-chain variant in a kindred with hereditary elliptocytosis. Characterization of the molecular defect as exon skipping due to a splice site mutation. Garbarz M, etal., J Clin Invest. 1991 Jul;88(1):76-81.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Novel beta-spectrin mutations in hereditary spherocytosis associated with decreased levels of mRNA. Maciag M, etal., Br J Haematol. 2009 Aug;146(3):326-32. doi: 10.1111/j.1365-2141.2009.07759.x. Epub 2009 Jun 15.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Spectrins in developing rat hippocampal cells. Ursitti JA, etal., Brain Res Dev Brain Res. 2001 Jul 23;129(1):81-93. doi: 10.1016/s0165-3806(01)00160-2.
Additional References at PubMed
PMID:379653   PMID:658175   PMID:6234993   PMID:8159688   PMID:9373263   PMID:9373273   PMID:10867799   PMID:14627610   PMID:16060676   PMID:18723693   PMID:20585040   PMID:21297961  
PMID:26514267   PMID:31505169  


Genomics

Comparative Map Data
Sptb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86101,043,512 - 101,170,389 (-)NCBIGRCr8
mRatBN7.2695,310,342 - 95,437,221 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl695,310,326 - 95,437,118 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx695,718,916 - 95,828,078 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0696,017,424 - 96,126,588 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0695,446,242 - 95,555,412 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0699,657,144 - 99,783,189 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,659,651 - 99,783,047 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06109,055,163 - 109,181,316 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4699,194,202 - 99,315,691 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1699,197,658 - 99,319,147 (-)NCBI
Celera693,748,706 - 93,857,362 (-)NCBICelera
Cytogenetic Map6q24NCBI
SPTB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381464,746,283 - 64,879,907 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1464,746,283 - 64,879,907 (-)EnsemblGRCh38hg38GRCh38
GRCh371465,213,001 - 65,346,625 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361464,282,754 - 64,359,619 (-)NCBINCBI36Build 36hg18NCBI36
Build 341464,302,870 - 64,416,308NCBI
Celera1445,270,736 - 45,347,605 (-)NCBICelera
Cytogenetic Map14q23.3NCBI
HuRef1445,384,969 - 45,462,806 (-)NCBIHuRef
CHM1_11465,152,596 - 65,229,440 (-)NCBICHM1_1
T2T-CHM13v2.01458,954,121 - 59,087,910 (-)NCBIT2T-CHM13v2.0
Sptb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391276,627,262 - 76,757,321 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1276,627,262 - 76,757,321 (-)EnsemblGRCm39 Ensembl
GRCm381276,580,488 - 76,710,547 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1276,580,488 - 76,710,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv371277,681,475 - 77,811,534 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361277,499,328 - 77,629,387 (-)NCBIMGSCv36mm8
Celera1277,672,725 - 77,802,629 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.73NCBI
Sptb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554665,097,116 - 5,167,596 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554665,013,963 - 5,170,186 (+)NCBIChiLan1.0ChiLan1.0
SPTB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21565,860,082 - 65,997,182 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11465,076,595 - 65,213,602 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01445,329,658 - 45,466,597 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11464,209,453 - 64,289,073 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1464,209,453 - 64,288,851 (-)Ensemblpanpan1.1panPan2
SPTB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1839,156,388 - 39,300,908 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl839,158,795 - 39,221,193 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha838,861,964 - 38,913,675 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0839,377,314 - 39,523,986 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl839,379,542 - 39,500,041 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1839,013,953 - 39,065,557 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0839,086,903 - 39,138,647 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0839,445,769 - 39,497,441 (-)NCBIUU_Cfam_GSD_1.0
Sptb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864065,651,095 - 65,775,749 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364958,415,912 - 8,486,039 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364958,415,950 - 8,540,590 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPTB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl788,812,718 - 88,954,306 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1788,812,717 - 88,954,471 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2795,193,318 - 95,335,373 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPTB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12441,957,438 - 42,038,522 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2441,978,595 - 42,038,516 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605330,129,480 - 30,266,419 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sptb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473436,202,011 - 36,270,942 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473436,151,701 - 36,272,058 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sptb
606 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:185
Count of miRNA genes:129
Interacting mature miRNAs:142
Transcripts:ENSRNOT00000009028
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat

Markers in Region
D6Got123  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2695,410,661 - 95,410,831 (+)MAPPERmRatBN7.2
Rnor_6.0699,757,445 - 99,757,614NCBIRnor6.0
Rnor_5.06109,155,582 - 109,155,751UniSTSRnor5.0
RGSC_v3.4699,289,184 - 99,289,354RGDRGSC3.4
RGSC_v3.4699,289,185 - 99,289,354UniSTSRGSC3.4
RGSC_v3.1699,292,641 - 99,292,810RGD
Celera693,830,892 - 93,831,051UniSTS
RH 3.4 Map6676.1RGD
RH 3.4 Map6676.1UniSTS
Cytogenetic Map6q24UniSTS
D6Got206  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2695,345,362 - 95,345,530 (+)MAPPERmRatBN7.2
Rnor_6.0699,692,158 - 99,692,325NCBIRnor6.0
Rnor_5.06109,090,178 - 109,090,345UniSTSRnor5.0
RGSC_v3.4699,211,276 - 99,211,444RGDRGSC3.4
RGSC_v3.4699,211,277 - 99,211,444UniSTSRGSC3.4
RGSC_v3.1699,214,733 - 99,214,900RGD
Celera693,765,781 - 93,765,931UniSTS
RH 3.4 Map6669.8RGD
RH 3.4 Map6669.8UniSTS
Cytogenetic Map6q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43 24 24 11 24 8 11 46 18 3 8
Low 3 29 13 8 13 28 35 23 8
Below cutoff 4 4 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009028   ⟹   ENSRNOP00000009028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl695,324,805 - 95,437,118 (-)Ensembl
Rnor_6.0 Ensembl699,659,651 - 99,783,047 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094264   ⟹   ENSRNOP00000097655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl695,310,326 - 95,437,118 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112302   ⟹   ENSRNOP00000082576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl695,310,326 - 95,437,118 (-)Ensembl
RefSeq Acc Id: NM_212522   ⟹   NP_997687
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86101,061,455 - 101,170,278 (-)NCBI
mRatBN7.2695,328,287 - 95,437,118 (-)NCBI
Rnor_6.0699,675,083 - 99,783,069 (-)NCBI
Rnor_5.06109,055,163 - 109,181,316 (-)NCBI
RGSC_v3.4699,194,202 - 99,315,691 (-)RGD
Celera693,748,706 - 93,857,362 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240244   ⟹   XP_006240306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86101,043,512 - 101,170,389 (-)NCBI
mRatBN7.2695,313,049 - 95,437,221 (-)NCBI
Rnor_6.0699,657,144 - 99,783,189 (-)NCBI
Rnor_5.06109,055,163 - 109,181,316 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594142   ⟹   XP_017449631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86101,043,512 - 101,170,374 (-)NCBI
mRatBN7.2695,313,049 - 95,437,221 (-)NCBI
Rnor_6.0699,657,144 - 99,783,189 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594143   ⟹   XP_017449632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86101,043,512 - 101,170,374 (-)NCBI
mRatBN7.2695,313,049 - 95,437,221 (-)NCBI
Rnor_6.0699,657,144 - 99,783,189 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_997687   ⟸   NM_212522
- UniProtKB: Q6XDA0 (UniProtKB/TrEMBL),   F1MAL3 (UniProtKB/TrEMBL),   A0A140UHX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240306   ⟸   XM_006240244
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AWM3 (UniProtKB/TrEMBL),   A0A8I6G9M6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449632   ⟸   XM_017594143
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AWM3 (UniProtKB/TrEMBL),   A0A8I6G9M6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449631   ⟸   XM_017594142
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AWM3 (UniProtKB/TrEMBL),   A0A8I6G9M6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009028   ⟸   ENSRNOT00000009028
RefSeq Acc Id: ENSRNOP00000097655   ⟸   ENSRNOT00000094264
RefSeq Acc Id: ENSRNOP00000082576   ⟸   ENSRNOT00000112302
Protein Domains
Calponin-homology (CH)   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A140UHX6-F1-model_v2 AlphaFold A0A140UHX6 1-2329 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694678
Promoter ID:EPDNEW_R5203
Type:initiation region
Name:Sptb_1
Description:spectrin, beta, erythrocytic
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0699,783,084 - 99,783,144EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303243 AgrOrtholog
BioCyc Gene G2FUF-37051 BioCyc
Ensembl Genes ENSRNOG00000006911 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009028 ENTREZGENE
  ENSRNOT00000009028.8 UniProtKB/TrEMBL
  ENSRNOT00000094264.1 UniProtKB/TrEMBL
  ENSRNOT00000112302.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.58.60 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/TrEMBL
  Calponin-like_dom_sf UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  PH_9 UniProtKB/TrEMBL
  PH_dom-like UniProtKB/TrEMBL
  PH_dom-spectrin-type UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/TrEMBL
  Spectrin_bsu UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/TrEMBL
KEGG Report rno:314251 UniProtKB/TrEMBL
NCBI Gene 314251 ENTREZGENE
PANTHER SPECTRIN BETA CHAIN, ERYTHROCYTIC UniProtKB/TrEMBL
  SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN UniProtKB/TrEMBL
Pfam PF00307 UniProtKB/TrEMBL
  PH_9 UniProtKB/TrEMBL
  Spectrin UniProtKB/TrEMBL
PhenoGen Sptb PhenoGen
PIRSF Spectrin_beta_subunit UniProtKB/TrEMBL
PRINTS SPECTRINPH UniProtKB/TrEMBL
PROSITE ACTININ_1 UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006911 RatGTEx
SMART SM00033 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  SPEC UniProtKB/TrEMBL
Superfamily-SCOP Calponin-homology UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  Spectrin repeat UniProtKB/TrEMBL
UniProt A0A140UHX6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AWM3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G9M6 ENTREZGENE, UniProtKB/TrEMBL
  F1MAL3 ENTREZGENE
  Q6XDA0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1MAL3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Sptb  spectrin, beta, erythrocytic  LOC679700  hypothetical protein LOC679700  Data merged from RGD:1584841 737654 PROVISIONAL
2008-09-18 Sptb  spectrin, beta, erythrocytic  Spnb1  spectrin beta 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-13 Spnb1  spectrin beta 1  LOC314251  erythroid spectrin beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC679700  hypothetical protein LOC679700  LOC687997  hypothetical protein LOC687997  Data merged from RGD:1594855 1643240 APPROVED
2006-11-20 LOC687997  hypothetical protein LOC687997      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC679700  hypothetical protein LOC679700      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-10-12 LOC314251        Symbol and Name status set to provisional 70820 PROVISIONAL