HHLA2 (HHLA2 member of B7 family) - Rat Genome Database

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Gene: HHLA2 (HHLA2 member of B7 family) Chlorocebus sabaeus
Analyze
Symbol: HHLA2
Name: HHLA2 member of B7 family
RGD ID: 18462037
Description: INVOLVED IN positive regulation of activated T cell proliferation (ortholog); positive regulation of cytokine production (ortholog); T cell costimulation (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: HERV-H LTR-associating 2; HERV-H LTR-associating protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12272,416,249 - 72,504,209 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2272,416,675 - 72,494,635 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604194,049,343 - 94,069,064 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
HHLA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12272,416,249 - 72,504,209 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2272,416,675 - 72,494,635 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604194,049,343 - 94,069,064 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
HHLA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383108,296,548 - 108,378,285 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3108,296,529 - 108,378,285 (+)EnsemblGRCh38hg38GRCh38
GRCh373108,015,395 - 108,097,132 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363109,504,022 - 109,579,816 (+)NCBINCBI36Build 36hg18NCBI36
Build 343109,504,021 - 109,579,815NCBI
Celera3106,417,960 - 106,493,752 (+)NCBICelera
Cytogenetic Map3q13.13NCBI
HuRef3105,394,593 - 105,470,415 (+)NCBIHuRef
CHM1_13107,985,483 - 108,061,288 (+)NCBICHM1_1
T2T-CHM13v2.03110,942,318 - 111,098,074 (+)NCBIT2T-CHM13v2.0
Gm35938
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391649,384,216 - 49,387,359 (-)NCBIGRCm39GRCm39mm39
GRCm381649,563,853 - 49,566,996 (-)NCBIGRCm38GRCm38mm10GRCm38
Celera1649,904,669 - 49,909,735 (-)NCBICelera
Cytogenetic Map16B5NCBI
Hhla2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81164,726,345 - 64,740,139 (+)NCBIGRCr8
mRatBN7.21151,257,681 - 51,271,408 (+)NCBImRatBN7.2mRatBN7.2
Rnor_6.01153,866,424 - 53,875,343 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Celera1150,898,171 - 50,907,090 (+)NCBICelera
Cytogenetic Map11q21NCBI
Hhla2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554278,926,229 - 9,009,156 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554278,944,387 - 9,007,648 (+)NCBIChiLan1.0ChiLan1.0
HHLA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22106,199,720 - 106,360,399 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13106,204,499 - 106,365,178 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03105,348,992 - 105,496,944 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13112,348,805 - 112,430,321 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3112,380,756 - 112,430,321 (+)Ensemblpanpan1.1panPan2
HHLA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13313,606,724 - 13,622,678 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3313,712,743 - 13,728,519 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03313,772,779 - 13,788,553 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13313,642,464 - 13,658,013 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03313,708,136 - 13,723,906 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03314,121,047 - 14,136,600 (+)NCBIUU_Cfam_GSD_1.0
Hhla2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602141,195,439 - 141,215,285 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366451,630,337 - 1,648,595 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HHLA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13151,156,800 - 151,298,330 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113151,153,982 - 151,298,324 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213160,195,331 - 160,288,536 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Hhla2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473141,151,649 - 41,248,520 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473141,153,064 - 41,251,779 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 16
Below cutoff 18 3 52

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000004365   ⟹   ENSCSAP00000002619
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2272,416,675 - 72,494,635 (-)Ensembl
RefSeq Acc Id: XM_038003283   ⟹   XP_037859211
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604194,049,343 - 94,069,064 (+)NCBI
RefSeq Acc Id: XM_038003284   ⟹   XP_037859212
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604194,049,343 - 94,060,275 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037859211 (Get FASTA)   NCBI Sequence Viewer  
  XP_037859212 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000002619.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000002619   ⟸   ENSCSAT00000004365
RefSeq Acc Id: XP_037859211   ⟸   XM_038003283
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R1Y0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037859212   ⟸   XM_038003284
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000006326 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000004365.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
KEGG Report csab:103228367 UniProtKB/TrEMBL
NCBI Gene HHLA2 ENTREZGENE
PANTHER BUTYROPHILIN UniProtKB/TrEMBL
Pfam V-set UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
SMART IGv UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A0D9R1Y0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-09 HHLA2  HHLA2 member of B7 family  HHLA2  HERV-H LTR-associating 2  Symbol and/or name change 5135510 APPROVED