Hhla2 (HHLA2 member of B7 family) - Rat Genome Database

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Gene: Hhla2 (HHLA2 member of B7 family) Rattus norvegicus
Analyze
Symbol: Hhla2
Name: HHLA2 member of B7 family
RGD ID: 11472061
Description: Predicted to be involved in T cell costimulation; positive regulation of activated T cell proliferation; and positive regulation of cytokine production. Orthologous to human HHLA2 (HHLA2 member of B7 family); INTERACTS WITH 17beta-estradiol (ortholog); benzo[a]pyrene (ortholog); bisphenol A (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: HERV-H LTR-associating 2; HERV-H LTR-associating protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81164,726,345 - 64,740,139 (+)NCBIGRCr8
mRatBN7.21151,257,681 - 51,271,408 (+)NCBImRatBN7.2mRatBN7.2
Rnor_6.01153,866,424 - 53,875,343 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Celera1150,898,171 - 50,907,090 (+)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References
Additional References at PubMed
PMID:23784006  


Genomics

Comparative Map Data
Hhla2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81164,726,345 - 64,740,139 (+)NCBIGRCr8
mRatBN7.21151,257,681 - 51,271,408 (+)NCBImRatBN7.2mRatBN7.2
Rnor_6.01153,866,424 - 53,875,343 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Celera1150,898,171 - 50,907,090 (+)NCBICelera
Cytogenetic Map11q21NCBI
HHLA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383108,296,548 - 108,378,285 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3108,296,529 - 108,378,285 (+)EnsemblGRCh38hg38GRCh38
GRCh373108,015,395 - 108,097,132 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363109,504,022 - 109,579,816 (+)NCBINCBI36Build 36hg18NCBI36
Build 343109,504,021 - 109,579,815NCBI
Celera3106,417,960 - 106,493,752 (+)NCBICelera
Cytogenetic Map3q13.13NCBI
HuRef3105,394,593 - 105,470,415 (+)NCBIHuRef
CHM1_13107,985,483 - 108,061,288 (+)NCBICHM1_1
T2T-CHM13v2.03110,942,318 - 111,098,074 (+)NCBIT2T-CHM13v2.0
Gm35938
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391649,384,216 - 49,387,359 (-)NCBIGRCm39GRCm39mm39
GRCm381649,563,853 - 49,566,996 (-)NCBIGRCm38GRCm38mm10GRCm38
Celera1649,904,669 - 49,909,735 (-)NCBICelera
Cytogenetic Map16B5NCBI
Hhla2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554278,926,229 - 9,009,156 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554278,944,387 - 9,007,648 (+)NCBIChiLan1.0ChiLan1.0
HHLA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22106,199,720 - 106,360,399 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13106,204,499 - 106,365,178 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03105,348,992 - 105,496,944 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13112,348,805 - 112,430,321 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3112,380,756 - 112,430,321 (+)Ensemblpanpan1.1panPan2
HHLA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13313,606,724 - 13,622,678 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3313,712,743 - 13,728,519 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03313,772,779 - 13,788,553 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13313,642,464 - 13,658,013 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03313,708,136 - 13,723,906 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03314,121,047 - 14,136,600 (+)NCBIUU_Cfam_GSD_1.0
Hhla2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602141,195,439 - 141,215,285 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366451,630,337 - 1,648,595 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HHLA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13151,156,800 - 151,298,330 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113151,153,982 - 151,298,324 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213160,195,331 - 160,288,536 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HHLA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12272,416,249 - 72,504,209 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2272,416,675 - 72,494,635 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604194,049,343 - 94,069,064 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hhla2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473141,151,649 - 41,248,520 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473141,153,064 - 41,251,779 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hhla2
124 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat


Expression


Sequence


RefSeq Acc Id: XM_017598146   ⟹   XP_017453635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81164,726,345 - 64,740,139 (+)NCBI
mRatBN7.21151,257,681 - 51,271,408 (+)NCBI
Rnor_6.01153,866,424 - 53,875,343 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_017453635 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_017453635   ⟸   XM_017598146
- Sequence:


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:11472061 AgrOrtholog
BioCyc Gene G2FUF-21430 BioCyc
NCBI Gene Hhla2 ENTREZGENE
PhenoGen Hhla2 PhenoGen


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-12 Hhla2  HHLA2 member of B7 family  Hhla2  HERV-H LTR-associating 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-08-02 Hhla2  HERV-H LTR-associating 2      Symbol and Name status set to provisional 70820 PROVISIONAL