CPXM2 (carboxypeptidase X, M14 family member 2) - Rat Genome Database

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Gene: CPXM2 (carboxypeptidase X, M14 family member 2) Chlorocebus sabaeus
Analyze
Symbol: CPXM2
Name: carboxypeptidase X, M14 family member 2
RGD ID: 18441912
Description: ENCODES a protein that exhibits carboxypeptidase activity (ortholog); INVOLVED IN proteolysis (ortholog); ASSOCIATED WITH breast ductal carcinoma (ortholog); invasive ductal carcinoma (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: inactive carboxypeptidase-like protein X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19116,410,136 - 116,555,770 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9116,410,128 - 116,555,511 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604877,723,484 - 77,869,318 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
CPXM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19116,410,136 - 116,555,770 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9116,410,128 - 116,555,511 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604877,723,484 - 77,869,318 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CPXM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810123,745,639 - 123,944,104 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10123,706,207 - 123,940,267 (-)EnsemblGRCh38hg38GRCh38
GRCh3710125,505,155 - 125,651,323 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610125,495,142 - 125,641,490 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410125,495,141 - 125,641,490NCBI
Celera10119,210,810 - 119,357,101 (-)NCBICelera
Cytogenetic Map10q26.13NCBI
HuRef10119,120,570 - 119,266,868 (-)NCBIHuRef
CHM1_110125,787,211 - 125,933,512 (-)NCBICHM1_1
T2T-CHM13v2.010124,622,492 - 124,821,277 (-)NCBIT2T-CHM13v2.0
Cpxm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397131,634,416 - 131,756,483 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7131,634,416 - 131,756,468 (-)EnsemblGRCm39 Ensembl
GRCm387132,032,687 - 132,154,765 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7132,032,687 - 132,154,739 (-)EnsemblGRCm38mm10GRCm38
MGSCv377139,234,493 - 139,346,424 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367131,881,159 - 131,993,082 (-)NCBIMGSCv36mm8
Celera7131,849,272 - 131,959,301 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map775.6NCBI
Cpxm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,266,930 - 196,377,350 (-)NCBIGRCr8
mRatBN7.21186,836,797 - 186,947,222 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1186,836,797 - 186,947,220 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1195,186,954 - 195,297,381 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01202,365,897 - 202,476,322 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01195,039,012 - 195,149,430 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01204,048,785 - 204,161,090 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1204,048,785 - 204,087,001 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01211,049,000 - 211,158,115 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41191,510,790 - 191,624,219 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11191,661,676 - 191,773,964 (-)NCBI
Celera1184,585,401 - 184,694,851 (-)NCBICelera
Cytogenetic Map1q41NCBI
Cpxm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554771,840,606 - 1,975,531 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554771,840,642 - 1,975,531 (-)NCBIChiLan1.0ChiLan1.0
CPXM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28135,588,322 - 135,735,921 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110135,593,728 - 135,741,271 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010120,302,984 - 120,449,022 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110124,576,161 - 124,721,359 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10124,576,161 - 124,721,359 (-)Ensemblpanpan1.1panPan2
CPXM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12833,219,823 - 33,380,852 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2833,220,890 - 33,467,746 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2833,284,486 - 33,412,252 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02833,776,621 - 33,904,851 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2833,776,640 - 34,059,105 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12833,333,240 - 33,461,276 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02833,325,593 - 33,454,253 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02833,575,878 - 33,705,412 (-)NCBIUU_Cfam_GSD_1.0
Cpxm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721313,225,717 - 13,311,170 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648612,251,199 - 12,345,542 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648612,250,128 - 12,335,578 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPXM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14133,246,526 - 133,376,489 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114133,246,521 - 133,376,378 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214144,880,552 - 145,027,128 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Cpxm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473723,156,028 - 23,299,522 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473723,156,008 - 23,299,312 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 21 13
Low 15 12 36
Below cutoff 5 11

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000002570   ⟹   ENSCSAP00000000872
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl9116,410,128 - 116,555,511 (-)Ensembl
RefSeq Acc Id: XM_007964326   ⟹   XP_007962517
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.19116,410,136 - 116,555,770 (-)NCBI
Vero_WHO_p1.0NW_02366604877,723,484 - 77,869,318 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007964327   ⟹   XP_007962518
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.19116,410,136 - 116,555,604 (-)NCBI
Vero_WHO_p1.0NW_02366604877,724,408 - 77,869,171 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007962517 (Get FASTA)   NCBI Sequence Viewer  
  XP_007962518 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000000872.1
Reference Protein Sequences
RefSeq Acc Id: XP_007962517   ⟸   XM_007964326
- Peptide Label: isoform X1
- UniProtKB: A0A0D9QWY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007962518   ⟸   XM_007964327
- Peptide Label: isoform X2
- UniProtKB: A0A0D9QWY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000000872   ⟸   ENSCSAT00000002570


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000004539 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000002570.1 UniProtKB/TrEMBL
Gene3D-CATH Carboxypeptidase-like, regulatory domain UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
  Zn peptidases UniProtKB/TrEMBL
InterPro CarboxyPept-like_regulatory UniProtKB/TrEMBL
  FA58C UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  Peptidase_M14 UniProtKB/TrEMBL
KEGG Report csab:103216658 UniProtKB/TrEMBL
NCBI Gene CPXM2 ENTREZGENE
PANTHER INACTIVE CARBOXYPEPTIDASE-LIKE PROTEIN X2 UniProtKB/TrEMBL
  PROTEASE M14 CARBOXYPEPTIDASE UniProtKB/TrEMBL
Pfam CarboxypepD_reg UniProtKB/TrEMBL
  F5_F8_type_C UniProtKB/TrEMBL
  Peptidase_M14 UniProtKB/TrEMBL
PRINTS CRBOXYPTASEA UniProtKB/TrEMBL
PROSITE CARBOXYPEPT_ZN_1 UniProtKB/TrEMBL
  FA58C_1 UniProtKB/TrEMBL
  FA58C_2 UniProtKB/TrEMBL
  FA58C_3 UniProtKB/TrEMBL
SMART FA58C UniProtKB/TrEMBL
  Zn_pept UniProtKB/TrEMBL
Superfamily-SCOP SSF49464 UniProtKB/TrEMBL
  SSF49785 UniProtKB/TrEMBL
  Zn-dependent exopeptidases UniProtKB/TrEMBL
UniProt A0A0D9QWY3 ENTREZGENE, UniProtKB/TrEMBL