STAT5A (signal transducer and activator of transcription 5A) - Rat Genome Database

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Gene: STAT5A (signal transducer and activator of transcription 5A) Chlorocebus sabaeus
Analyze
Symbol: STAT5A
Name: signal transducer and activator of transcription 5A
RGD ID: 18385617
Description: ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN activated T cell proliferation (ortholog); B cell differentiation (ortholog); cell population proliferation (ortholog); PARTICIPATES IN erythropoietin signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; interleukin-12 signaling pathway; ASSOCIATED WITH Acute-Phase Reaction (ortholog); adenocarcinoma (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,959,265 - 63,986,627 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,960,515 - 63,985,026 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,770,565 - 34,795,956 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activated T cell proliferation  (ISO)
B cell differentiation  (ISO)
cell population proliferation  (ISO)
cell surface receptor signaling pathway via JAK-STAT  (IEA,ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cytokine-mediated signaling pathway  (IEA,ISO)
defense response  (IEA)
development of secondary female sexual characteristics  (ISO)
development of secondary male sexual characteristics  (ISO)
eosinophil differentiation  (IEA)
epithelial cell differentiation involved in prostate gland development  (ISO)
erythrocyte differentiation  (ISO)
female pregnancy  (ISO)
gamma-delta T cell differentiation  (ISO)
growth hormone receptor signaling pathway via JAK-STAT  (IEA)
interleukin-15-mediated signaling pathway  (IEA)
interleukin-2-mediated signaling pathway  (IEA)
interleukin-3-mediated signaling pathway  (IEA)
interleukin-4-mediated signaling pathway  (IEA)
interleukin-5-mediated signaling pathway  (IEA)
interleukin-9-mediated signaling pathway  (IEA)
lactation  (IEA,ISO)
lipid storage  (ISO)
luteinization  (ISO)
lymphocyte differentiation  (ISO)
mammary gland development  (ISO)
mammary gland epithelium development  (ISO)
mammary gland involution  (ISO)
mast cell apoptotic process  (ISO)
mast cell differentiation  (ISO)
mast cell proliferation  (ISO)
mitotic cell cycle  (ISO)
multicellular organismal reproductive process  (ISO)
myeloid cell apoptotic process  (ISO)
natural killer cell differentiation  (ISO)
natural killer cell mediated cytotoxicity  (ISO)
negative regulation of erythrocyte differentiation  (ISO)
negative regulation of mast cell apoptotic process  (ISO)
negative regulation of myeloid cell apoptotic process  (ISO)
obsolete cellular response to organic substance  (IEA)
Peyer's patch development  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of B cell differentiation  (ISO)
positive regulation of blood vessel endothelial cell migration  (IEA)
positive regulation of cell population proliferation  (ISO)
positive regulation of endothelial cell proliferation  (IEA)
positive regulation of gamma-delta T cell differentiation  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-2 production  (ISO)
positive regulation of lymphocyte differentiation  (ISO)
positive regulation of mast cell differentiation  (ISO)
positive regulation of mast cell proliferation  (ISO)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of natural killer cell differentiation  (ISO)
positive regulation of natural killer cell mediated cytotoxicity  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
prostate gland epithelium morphogenesis  (ISO)
reelin-mediated signaling pathway  (IEA,ISO)
regulation of cell adhesion  (ISO)
regulation of cell population proliferation  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of epithelial cell differentiation  (ISO)
regulation of multicellular organism growth  (ISO)
regulation of steroid metabolic process  (ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
response to ethanol  (ISO)
response to nutrient levels  (ISO)
response to peptide hormone  (IEA,ISO)
signal transduction  (IEA)
T cell differentiation in thymus  (ISO)
T cell homeostasis  (ISO)
T cell proliferation  (ISO)
taurine metabolic process  (ISO)
transcription by RNA polymerase II  (ISO)

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA,ISO)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
STAT5A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,959,265 - 63,986,627 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,960,515 - 63,985,026 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,770,565 - 34,795,956 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
STAT5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,287,439 - 42,311,943 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,287,547 - 42,311,943 (+)EnsemblGRCh38hg38GRCh38
GRCh371740,439,565 - 40,463,961 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,693,091 - 37,717,484 (+)NCBINCBI36Build 36hg18NCBI36
Build 341737,693,090 - 37,717,484NCBI
Celera1737,094,449 - 37,118,845 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,204,247 - 36,228,642 (+)NCBIHuRef
CHM1_11740,675,279 - 40,699,663 (+)NCBICHM1_1
T2T-CHM13v2.01743,143,926 - 43,168,430 (+)NCBIT2T-CHM13v2.0
Stat5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,750,177 - 100,775,995 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,750,177 - 100,775,995 (+)EnsemblGRCm39 Ensembl
GRCm3811100,859,351 - 100,885,169 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,859,351 - 100,885,169 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711100,720,665 - 100,746,483 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,675,494 - 100,701,259 (+)NCBIMGSCv36mm8
MGSCv3611101,635,936 - 101,661,700 (+)NCBIMGSCv36mm8
Cytogenetic Map11DNCBI
cM Map1163.77NCBI
Stat5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,285,859 - 86,310,187 (+)NCBIGRCr8
mRatBN7.21085,785,537 - 85,809,869 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,785,537 - 85,809,866 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,821,886 - 90,846,156 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,300,534 - 90,324,854 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,693,771 - 85,718,012 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,764,732 - 88,789,060 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,764,732 - 88,789,057 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,558,936 - 88,583,264 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,795,404 - 89,819,732 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,809,773 - 89,834,099 (+)NCBI
Celera1084,503,376 - 84,527,708 (+)NCBICelera
Cytogenetic Map10q31NCBI
Stat5a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,305,363 - 16,318,534 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,305,363 - 16,319,219 (+)NCBIChiLan1.0ChiLan1.0
LOC100988550
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,673,101 - 22,696,260 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,563,275 - 24,586,438 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,005,025 - 15,029,110 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11715,228,465 - 15,251,783 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,228,465 - 15,251,783 (-)Ensemblpanpan1.1panPan2
STAT5A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,616,041 - 20,638,523 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,617,151 - 20,638,103 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,077,547 - 20,099,955 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,335,685 - 21,357,957 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,288,139 - 21,357,497 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,120,814 - 20,142,574 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,387,762 - 20,409,305 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,490,411 - 20,512,845 (-)NCBIUU_Cfam_GSD_1.0
STAT5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,474,227 - 20,499,138 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,474,221 - 20,498,785 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21224,563,982 - 24,581,115 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 34 18 24
Low 2 2 36
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000001166   ⟹   ENSCSAP00000014906
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1663,960,515 - 63,985,026 (-)Ensembl
RefSeq Acc Id: XM_008012648   ⟹   XP_008010839
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11663,959,265 - 63,986,627 (-)NCBI
Vero_WHO_p1.0NW_02366607734,770,565 - 34,795,652 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037993176   ⟹   XP_037849104
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607734,770,565 - 34,795,050 (-)NCBI
RefSeq Acc Id: XM_037993177   ⟹   XP_037849105
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607734,770,565 - 34,794,872 (-)NCBI
RefSeq Acc Id: XM_037993178   ⟹   XP_037849106
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607734,770,565 - 34,795,956 (-)NCBI
RefSeq Acc Id: XM_037993179   ⟹   XP_037849107
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607734,770,565 - 34,795,038 (-)NCBI
RefSeq Acc Id: XM_037993181   ⟹   XP_037849109
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607734,770,565 - 34,795,455 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008010839   ⟸   XM_008012648
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S217 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000014906   ⟸   ENSCSAT00000001166
RefSeq Acc Id: XP_037849106   ⟸   XM_037993178
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S217 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037849109   ⟸   XM_037993181
- Peptide Label: isoform X4
- UniProtKB: A0A0D9S217 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037849104   ⟸   XM_037993176
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S217 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037849107   ⟸   XM_037993179
- Peptide Label: isoform X3
- UniProtKB: A0A0D9S217 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037849105   ⟸   XM_037993177
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S217 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000003196 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000001166.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.532.10 UniProtKB/TrEMBL
  2.60.40.630 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  STAT transcription factor, all-alpha domain UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  STAT UniProtKB/TrEMBL
  STAT5_CCD UniProtKB/TrEMBL
  STAT5a/5b UniProtKB/TrEMBL
  STAT_linker UniProtKB/TrEMBL
  STAT_N_sf UniProtKB/TrEMBL
  STAT_TF_alpha UniProtKB/TrEMBL
  STAT_TF_coiled-coil UniProtKB/TrEMBL
  STAT_TF_DNA-bd UniProtKB/TrEMBL
  STAT_TF_DNA-bd_N UniProtKB/TrEMBL
  STAT_TF_prot_interaction UniProtKB/TrEMBL
NCBI Gene STAT5A ENTREZGENE
PANTHER PTHR11801 UniProtKB/TrEMBL
  PTHR11801:SF47 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  STAT_alpha UniProtKB/TrEMBL
  STAT_bind UniProtKB/TrEMBL
  STAT_int UniProtKB/TrEMBL
  STAT_linker UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  STAT_int UniProtKB/TrEMBL
Superfamily-SCOP SSF47655 UniProtKB/TrEMBL
  SSF48092 UniProtKB/TrEMBL
  SSF49417 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A0D9S217 ENTREZGENE, UniProtKB/TrEMBL