RGD Reference Report - Proliferation and apoptosis in PhIP-induced rat mammary gland carcinomas with elevated phosphotyrosine-STAT5a. - Rat Genome Database

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Proliferation and apoptosis in PhIP-induced rat mammary gland carcinomas with elevated phosphotyrosine-STAT5a.

Authors: Papaconstantinou, AD  Snyderwine, EG 
Citation: Papaconstantinou AD and Snyderwine EG, FEBS Lett. 2007 Jan 9;581(1):29-33. Epub 2006 Dec 5.
RGD ID: 2291927
Pubmed: PMID:17173897   (View Abstract at PubMed)
DOI: DOI:10.1016/j.febslet.2006.11.071   (Journal Full-text)

In the present study we addressed whether proliferation and apoptosis in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary gland carcinomas were different between carcinomas with high and low expression of phosphotyrosine (pY)-STAT5a. We determined that carcinomas with high pY-STAT5a were more proliferative (MIB5 immunostaining) and had a higher expression of cyclin D1 and estrogen receptor alpha. Furthermore, carcinomas with elevated pY-STAT5a demonstrated lower apoptosis as measured by the TUNEL assay and the Bcl-2 to Bax ratio, and showed increased expression of the long and short isoforms of the prolactin receptor. The results of this study are consistent with the notion that activated STAT5a may provide a growth advantage in some types of mammary gland cancers.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Mammary Neoplasms  ISOStat5a (Rattus norvegicus)2291927; 2291927protein:increased tyrosine phosphorylation:mammary glandRGD 
Experimental Mammary Neoplasms  IEP 2291927protein:increased tyrosine phosphorylation:mammary glandRGD 

Objects Annotated

Genes (Rattus norvegicus)
Stat5a  (signal transducer and activator of transcription 5A)

Genes (Mus musculus)
Stat5a  (signal transducer and activator of transcription 5A)

Genes (Homo sapiens)
STAT5A  (signal transducer and activator of transcription 5A)


Additional Information