GAMT (guanidinoacetate N-methyltransferase)

Gene: GAMT (guanidinoacetate N-methyltransferase) Chlorocebus sabaeus

Analyze

Symbol:

GAMT

Name:

guanidinoacetate N-methyltransferase

RGD ID:

18376282

Description:

ENCODES a protein that exhibits guanidinoacetate N-methyltransferase activity (ortholog); identical protein binding (ortholog); S-adenosylmethionine-dependent methyltransferase activity (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); creatine biosynthetic process (ortholog); embryonic liver development (ortholog); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; creatine metabolic pathway; ASSOCIATED WITH amino acid metabolic disorder (ortholog); cerebral creatine deficiency syndrome (ortholog); cyclic hematopoiesis (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	1,165,016 - 1,178,458 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	1,164,259 - 1,178,354 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666081	7,693,065 - 7,697,357 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amino acid metabolic disorder (ISO)

cerebral creatine deficiency syndrome (ISO)

cyclic hematopoiesis (ISO)

epilepsy (ISO)

genetic disease (ISO)

guanidinoacetate methyltransferase deficiency (ISO)

intellectual disability (ISO)

Leigh disease (ISO)

mitochondrial complex I deficiency (ISO)

Nervous System Malformations (ISO)

nuclear type mitochondrial complex I deficiency 1 (ISO)

pre-eclampsia (ISO)

Subacute Necrotizing Encephalopathy of Leigh, Infantile (ISO)

transient cerebral ischemia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

animal organ morphogenesis (ISO)

creatine biosynthetic process (IEA,ISO)

embryonic liver development (ISO)

methylation (IEA)

regulation of multicellular organism growth (ISO)

S-adenosylhomocysteine metabolic process (ISO)

S-adenosylmethionine metabolic process (ISO)

spermatogenesis (ISO)

Cellular Component

cytoplasm (IEA)

nucleus (IEA)

Molecular Function

guanidinoacetate N-methyltransferase activity (IEA,ISO)

identical protein binding (ISO)

methyltransferase activity (IEA)

protein arginine N5-methyltransferase activity (IEA)

protein binding (ISO)

S-adenosylmethionine-dependent methyltransferase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

AGAT deficiency pathway (ISO)

arginine and proline metabolic pathway (ISO)

creatine metabolic pathway (ISO)

dihydropyrimidine dehydrogenase deficiency pathway (ISO)

dimethylglycine dehydrogenase deficiency pathway (ISO)

guanidinoacetate methyltransferase deficiency pathway (ISO)

gyrate atrophy pathway (ISO)

homocysteine metabolic pathway (ISO)

hyperprolinemia type I pathway (ISO)

hyperprolinemia type II pathway (ISO)

methionine cycle/metabolic pathway (ISO)

nonketotic hyperglycinemia pathway (ISO)

ornithine translocase deficiency pathway (ISO)

prolidase deficiency pathway (ISO)

sarcosinemia pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

GAMT
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	1,165,016 - 1,178,458 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	1,164,259 - 1,178,354 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666081	7,693,065 - 7,697,357 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

GAMT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	1,397,026 - 1,401,542 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	1,397,026 - 1,401,570 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	1,397,025 - 1,401,541 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	1,348,088 - 1,352,552 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	1,349,607 - 1,352,552	NCBI
Celera	19	1,331,366 - 1,335,830 (-)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	1,171,878 - 1,176,401 (-)	NCBI		HuRef
CHM1_1	19	1,397,126 - 1,401,670 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	1,367,024 - 1,371,540 (-)	NCBI		T2T-CHM13v2.0

Gamt
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	80,093,985 - 80,096,846 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	80,093,985 - 80,096,846 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	80,258,151 - 80,261,025 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	80,258,151 - 80,261,012 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	79,720,896 - 79,723,713 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	79,661,328 - 79,664,141 (-)	NCBI		MGSCv36	mm8
Celera	10	81,273,024 - 81,275,841 (-)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Gamt
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	10,099,267 - 10,102,083 (+)	NCBI		GRCr8
mRatBN7.2	7	9,448,590 - 9,451,413 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	9,448,628 - 9,451,778 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	12,331,403 - 12,334,202 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	14,206,743 - 14,209,542 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	12,068,078 - 12,070,877 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	12,314,848 - 12,317,998 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	12,314,848 - 12,317,998 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	12,484,097 - 12,487,698 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	10,959,990 - 10,962,720 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	10,959,989 - 10,962,720 (+)	NCBI
Celera	7	7,625,330 - 7,628,480 (+)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

Gamt
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	6,536,544 - 6,539,424 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	6,536,541 - 6,539,424 (+)	NCBI	ChiLan1.0	ChiLan1.0

GAMT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	5,743,093 - 5,749,393 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	4,980,010 - 4,986,337 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1	19	1,371,043 - 1,375,514 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	1,371,312 - 1,375,461 (-)	Ensembl	panpan1.1		panPan2

GAMT
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	57,440,698 - 57,442,588 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	57,231,269 - 57,233,795 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	58,170,588 - 58,173,114 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	58,170,577 - 58,173,106 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	57,226,557 - 57,229,082 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	57,706,242 - 57,708,766 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	57,908,247 - 57,910,773 (+)	NCBI		UU_Cfam_GSD_1.0

Gamt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	217,110,293 - 217,113,339 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	721,313 - 724,524 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	721,436 - 724,475 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GAMT
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	77,076,566 - 77,079,759 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	77,076,566 - 77,079,751 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	77,968,844 - 77,972,039 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Gamt
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	7,294,327 - 7,297,303 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	7,294,380 - 7,297,787 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	25		27
Low	11	20	33
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007994603	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007994604	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000010223 ⟹ ENSCSAP00000008320

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	6	1,164,259 - 1,178,354 (-)	Ensembl

RefSeq Acc Id:

XM_007994604 ⟹ XP_007992795

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	6	1,165,016 - 1,178,438 (-)	NCBI
Vero_WHO_p1.0	NW_023666081	7,693,065 - 7,697,357 (+)	NCBI

Sequence:

show sequence

CCGGGCCTGTTGGACCCGCCCCCGGCCCACAAGGCCCTGCAGGGAGCGGGCCCCCGCGCTGCGC
GATCCAAGTCGGGTCGCCGTCCAGCCTGCAGCATGAGCGCCCCCAACGCGACCCCCATCTTCGC
GTCCGGCGAGAACTGCAGCCCCGCGTGGGGGGCGGCGCCCGCGGCCTACGACGCGGCGGACACG
CACCTGCGCATCCTGGGCAAGCCGGTGATGGAGCGCTGGGAGACCCCCTATATGCACTCGCTGG
CCGCCGCCGCCGCCTCCAAAGGGGGCCGGGTCCTGGAGGTGGGCTTTGGCATGGCCATCGCAGC
GTCGAAGGTGCAGGAGGCGCCCATTGATGAGCACTGGATCATCGAGTGTAATGACGGCGTCTTC
CAGCGGCTCCAGGACTGGGCCCCGCGGCAGACACACAAGGTCGTCCCCTTGAAAGGCCTGTGGG
AGGATGTGGCGCCCACCCTGCCTGACGGTCACTTTGATGGGATCCTGTATGACACGTACCCACT
CTCGGAGGAAACCTGGCACACACACCAGTTCAACTTCATCAAGAACCACGCCTTTCGCCTGCTA
AAGCCAGGGGGTGTCCTCACCTACTGCAACCTCACCTCCTGGGGGGAGCTGATGAAGTCCAAGT
ACTCAGACATCACCACCATGTTTGAGGAGACACAGGTGCCTGCGCTGCTGGAGGCCGGCTTCCG
GAGGGAGAACATCCGTACCGAGGTGATGGCGCTGGTCCCACCAGCCGACTGCCGCTACTACGCC
TTCCCGCAGATGATCACGCCCCTGGTCACCAAGGGATGAGCCCCGACCCCGGCCCGGCCACACC
CGTGCCCTCCTCCGTGCCTTCCTGGCCGGGAGTCTAGGCTCTCCCGCCAGCCCCGGGCTGATCC
CGGCTGTGTCACCAGCAGCTTTCCCAGCTTCTCTGTGAGGGGTCACACTGCCCGCTGCCGGGTC
TCCGAGGTGAAGTAAACACCGGTGCTGGCTTGGCTGGTTTGTCCACAGTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007992795	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000008320
	ENSCSAP00000008320.1

RefSeq Acc Id:	XP_007992795 ⟸ XM_007994604
- UniProtKB:	A0A0D9RI81 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000008320 ⟸ ENSCSAT00000010223

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000012137	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000010223.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.150	UniProtKB/TrEMBL
InterPro	GuanidinoAc_N-MeTrfase	UniProtKB/TrEMBL
	RMT2_dom	UniProtKB/TrEMBL
	SAM-dependent_MTases	UniProtKB/TrEMBL
NCBI Gene	GAMT	ENTREZGENE
PANTHER	GUANIDINOACETATE N-METHYLTRANSFERASE	UniProtKB/TrEMBL
	GUANIDINOACETATE N-METHYLTRANSFERASE	UniProtKB/TrEMBL
PIRSF	GAMT	UniProtKB/TrEMBL
PROSITE	SAM_RMT2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53335	UniProtKB/TrEMBL
UniProt	A0A0D9RI81	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB