SHB (SH2 domain containing adaptor protein B) - Rat Genome Database

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Gene: SHB (SH2 domain containing adaptor protein B) Chlorocebus sabaeus
Analyze
Symbol: SHB
Name: SH2 domain containing adaptor protein B
RGD ID: 18374431
Description: ENCODES a protein that exhibits phosphotyrosine residue binding (inferred); signaling receptor complex adaptor activity (inferred); INVOLVED IN B cell proliferation (ortholog); blood vessel development (ortholog); blood vessel morphogenesis (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; vascular endothelial growth factor signaling pathway; FOUND IN cytoplasmic ribonucleoprotein granule (inferred); cytosol (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: SH2 domain-containing adapter protein B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11242,520,803 - 42,669,892 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1242,520,905 - 42,669,211 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603839,581,717 - 39,730,643 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SHB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11242,520,803 - 42,669,892 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1242,520,905 - 42,669,211 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603839,581,717 - 39,730,643 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SHB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38937,915,898 - 38,069,227 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl937,915,898 - 38,069,227 (-)EnsemblGRCh38hg38GRCh38
GRCh37937,915,895 - 38,069,224 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36937,905,895 - 38,059,210 (-)NCBINCBI36Build 36hg18NCBI36
Build 34937,909,613 - 38,059,208NCBI
Celera937,849,067 - 38,002,380 (-)NCBICelera
Cytogenetic Map9p13.1NCBI
HuRef937,868,289 - 38,021,594 (-)NCBIHuRef
CHM1_1937,917,509 - 38,070,825 (-)NCBICHM1_1
T2T-CHM13v2.0937,939,809 - 38,093,156 (-)NCBIT2T-CHM13v2.0
Shb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39445,423,278 - 45,530,804 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl445,423,278 - 45,532,470 (-)EnsemblGRCm39 Ensembl
GRCm38445,423,276 - 45,530,828 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl445,423,278 - 45,532,470 (-)EnsemblGRCm38mm10GRCm38
MGSCv37445,436,148 - 45,543,700 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36445,444,376 - 45,551,862 (-)NCBIMGSCv36mm8
MGSCv36444,263,381 - 44,370,910 (-)NCBIMGSCv36mm8
Celera445,444,918 - 45,556,568 (-)NCBICelera
Cytogenetic Map4B1NCBI
cM Map424.0NCBI
Shb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8564,473,694 - 64,581,072 (-)NCBIGRCr8
mRatBN7.2559,678,066 - 59,785,443 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl559,678,216 - 59,785,538 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0560,970,650 - 61,077,881 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl560,971,257 - 61,077,627 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0565,479,290 - 65,587,205 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4561,983,643 - 62,090,620 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera558,246,193 - 58,353,269 (-)NCBICelera
Cytogenetic Map5q22NCBI
Shb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541928,421,354 - 28,558,823 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541928,423,354 - 28,555,948 (+)NCBIChiLan1.0ChiLan1.0
SHB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21186,515,564 - 86,730,162 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1986,522,079 - 86,673,682 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0937,768,566 - 37,921,897 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1938,694,980 - 38,843,827 (-)NCBIpanpan1.1PanPan1.1panPan2
SHB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11154,189,580 - 54,329,004 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1154,189,843 - 54,329,325 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1152,615,325 - 52,754,488 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01155,298,243 - 55,437,485 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1155,298,508 - 55,438,186 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11153,796,294 - 53,935,436 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01153,826,088 - 53,965,258 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01154,522,809 - 54,661,888 (-)NCBIUU_Cfam_GSD_1.0
Shb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947169,150,521 - 169,284,871 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365245,701,566 - 5,834,539 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365245,698,101 - 5,832,801 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1238,681,194 - 238,826,429 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11238,680,804 - 238,826,424 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21266,638,474 - 266,670,709 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Shb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248253,845,092 - 3,973,636 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248253,846,604 - 3,972,780 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 20 37
Low 16 20 23
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000008929   ⟹   ENSCSAP00000007063
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1242,520,905 - 42,669,211 (+)Ensembl
RefSeq Acc Id: XM_007968663   ⟹   XP_007966854
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11242,520,803 - 42,669,892 (+)NCBI
Vero_WHO_p1.0NW_02366603839,581,717 - 39,730,643 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037998230   ⟹   XP_037854158
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603839,582,085 - 39,690,953 (+)NCBI
Protein Sequences
Protein RefSeqs XP_007966854 (Get FASTA)   NCBI Sequence Viewer  
  XP_037854158 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000007063.1
Reference Protein Sequences
RefSeq Acc Id: XP_007966854   ⟸   XM_007968663
- Peptide Label: isoform X1
- UniProtKB: A0A0D9REM4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037854158   ⟸   XM_037998230
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCSAP00000007063   ⟸   ENSCSAT00000008929


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010845 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008929.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
InterPro SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SHB_SH2 UniProtKB/TrEMBL
NCBI Gene SHB ENTREZGENE
PANTHER HEAVYWEIGHT, ISOFORM A UniProtKB/TrEMBL
  PTHR15127:SF31 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
Superfamily-SCOP SSF55550 UniProtKB/TrEMBL
UniProt A0A0D9REM4 ENTREZGENE, UniProtKB/TrEMBL