PRSS58 (serine protease 58) - Rat Genome Database

Name: PRSS58
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: PRSS58 (serine protease 58) Chlorocebus sabaeus

Analyze

Symbol:

PRSS58

Name:

serine protease 58

RGD ID:

18355964

Description:

ENCODES a protein that exhibits serine-type endopeptidase activity (inferred); serine-type peptidase activity (inferred); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH Hereditary Pancreatitis (ortholog); FOUND IN extracellular space (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

protease, serine 58

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PRSS58 (serine protease 58)	NCBI	Ortholog
Mus musculus (house mouse):	Prss58 (serine protease 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Prss58 (serine protease 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Prss58 (serine protease 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PRSS58 (serine protease 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC475522 (serine protease 58-like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Prss58 (serine protease 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PRSS58 (serine protease 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Prss58 (serine protease 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	110,988,537 - 110,994,720 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	110,988,631 - 110,994,088 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666072	7,694,375 - 7,702,860 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Hereditary Pancreatitis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proteolysis (IEA)

Cellular Component

extracellular space (IEA)

Molecular Function

serine-type endopeptidase activity (IEA)

serine-type peptidase activity (IEA)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

PRSS58
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	110,988,537 - 110,994,720 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	110,988,631 - 110,994,088 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666072	7,694,375 - 7,702,860 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

PRSS58
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	142,252,143 - 142,258,058 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	142,252,143 - 142,258,058 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	141,951,963 - 141,957,878 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	141,598,441 - 141,604,347 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	7	136,729,455 - 136,735,370 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI
HuRef	7	136,246,697 - 136,252,617 (-)	NCBI		HuRef
CHM1_1	7	141,886,110 - 141,892,030 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	143,567,197 - 143,573,112 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	141,290,166 - 141,296,085 (-)	NCBI

Prss58
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	40,872,196 - 40,877,321 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	40,872,204 - 40,877,321 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	40,895,262 - 40,900,387 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	40,895,270 - 40,900,387 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	40,845,261 - 40,850,386 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	40,824,869 - 40,829,994 (-)	NCBI		MGSCv36	mm8
Celera	6	40,881,514 - 40,886,641 (-)	NCBI		Celera
Cytogenetic Map	6	B1	NCBI
cM Map	6	18.94	NCBI

Prss58
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	70,719,326 - 70,731,158 (-)	NCBI		GRCr8
mRatBN7.2	4	69,752,646 - 69,757,306 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	69,752,573 - 69,756,962 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	74,676,103 - 74,680,032 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	70,597,244 - 70,601,173 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	69,010,706 - 69,014,647 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	69,145,435 - 69,152,111 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	69,145,397 - 69,149,520 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	133,935,374 - 133,939,671 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	68,534,119 - 68,538,075 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	68,810,248 - 68,814,205 (-)	NCBI
Celera	4	64,743,249 - 64,747,205 (-)	NCBI		Celera
Cytogenetic Map	4	q23	NCBI

Prss58
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955494	1,277,297 - 1,283,748 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955494	1,277,333 - 1,283,610 (+)	NCBI	ChiLan1.0	ChiLan1.0

PRSS58
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	179,035,095 - 179,042,947 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	31,045,350 - 31,053,202 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	134,179,697 - 134,185,609 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	146,649,838 - 146,655,755 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	146,649,838 - 146,655,728 (-)	Ensembl	panpan1.1		panPan2

LOC475522
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	7,001,061 - 7,005,198 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	7,001,408 - 7,005,186 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	7,859,857 - 7,863,994 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	6,922,105 - 6,926,242 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	6,922,452 - 6,926,230 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	6,875,606 - 6,879,743 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	6,716,965 - 6,721,091 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	6,785,611 - 6,789,748 (+)	NCBI		UU_Cfam_GSD_1.0

Prss58
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	13,166,133 - 13,170,467 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936971	193,268 - 195,843 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936971	193,268 - 195,843 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PRSS58
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	7,715,879 - 7,723,937 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	7,715,969 - 7,725,465 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	7,984,174 - 7,992,282 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Prss58
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624821	9,612,653 - 9,618,461 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium
Low		15
Below cutoff	5	2	4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007983207	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007983208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007983209	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037991185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000040	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000005952 ⟹ ENSCSAP00000004165

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	21	110,988,631 - 110,994,088 (-)	Ensembl

RefSeq Acc Id:

XM_007983207 ⟹ XP_007981398

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	21	110,988,537 - 110,994,718 (-)	NCBI
Vero_WHO_p1.0	NW_023666072	7,694,375 - 7,702,826 (-)	NCBI

Sequence:

show sequence

AACCCCAACAGCAAGCACAGATCCTGGTACAAGTTAGATACATAAGATAAATAATATGCAGGTT
GGTTCACAGAATAAATGGATAAACAGTGACATGAAGGAAAAGGTTAATGTATTTCGAAGAGGAG
TTTAATGTCAGGCAGAGGAAGCAATGTCAGCTCCACAGGGCTATGTTATGTCAACTGGAGAAAA
ATACCATCTCATAGTGGGGGATAGCATCACACAGACAGGAGGGGCAGCAGCCCACACATAGTTT
AAAGGGGCACCTGCCTGCCAAGGCTGGCAAAAAGGAGACCAGACAGGAGGTGGCTATAGAGACA
TCATGAACTTCAACTTATCTTAGCTTTGGTACTTTCTTCCCTGAAGACAGAGTGCAGAACTCTG
AATTCCAGAATCATTTCAATCGTTTTGGGGACCAGTCACTTGATTCTATTCTTATCTCTCTGAC
AGATGACACTACGCCCTCCTCTGAGTAATGGACACCATTTCTAAAACTGAATCTTGCTACTAAA
ATAATTCAGATGATATATTTTTCCAATTCTAGAATCTTGCTTTATTTTATTTAGTCGTTTTCTC
TCTCTCTTCCATGTTTTCCAGAGACTGCAGTTAAACTGGGCTTTCAACATCAACATGAAGTTTA
TCCTCCTTTGGGCTCTCTTGAATCTGACTGTTGCTTTGGCCTTTAATCCAGATTACACAGTCAG
TTCCACTCCTCCCTACTTGGTCTACTTGAAATCTGACTACTTGCCCTGCGCTGGAGTCCTGATC
CACCCACTTTGGGTGATCACAGCTGCACACTGCAATTTACCAAAGCTTCGGGTGATATTGGGGG
TTACAATCCCAGCAGACTCCAGTGAAAACCATCTGCAAGTGATTGGCTATGAGAAGATGATTCA
TCACCCACGCTTCTCAATCACGTCTATTGATCATGACATCATGCTCATCAAGCTGAAAACAGAG
GCTGAACTCAACGACTACGTGAAACTAGCCAACCTGCCCTACCAAACTATCTCTGAGAATACCA
TGTGCTCTGTCTCCACCTGGAGCTACAACGTGTGTGATATCTACAAGGAGCCTGATTCACTGCA
AACTGTGAACATCTCTGTAATCTCCAAGCCGCAGTGCCGCGATGCCTATCAAACCTACAACATC
AAGGAAAATATGCTGTGTGTGGGCATCGTGCCAGGAAGGAGGCAGCCCTGCAAGGAAGTTTCTG
CTGCCCCGGCAATCTGCAATGGGATGCTTCAAGGAATCCTGTCTTTTGCGGATGGATGTGTTTT
GAGAGCCGATGTTGGCATCTATGCCAAAATTTTTTACTATGTACCCTGGATTGAAAATGTAATC
CAAAATAACTGAGCTCCTGCGGCAGTTGTGGACCATGTGACACGCTTGTCCCCATCGTTCAGCT
TTAGAATTGAATATAAATTAATTCCTTACATTGCCCTATGCA

hide sequence

RefSeq Acc Id:

XM_037991185 ⟹ XP_037847113

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666072	7,694,375 - 7,702,860 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_007981398	(Get FASTA)	NCBI Sequence Viewer
	XP_037847113	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000004165.1

RefSeq Acc Id:	XP_007981398 ⟸ XM_007983207
- UniProtKB:	A0A0D9R6C6 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000004165 ⟸ ENSCSAT00000005952

RefSeq Acc Id:	XP_037847113 ⟸ XM_037991185
- UniProtKB:	A0A0D9R6C6 (UniProtKB/TrEMBL)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000007906	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000005952.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
InterPro	Peptidase_S1_PA	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	Trypsin_dom	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
KEGG Report	csab:103227053	UniProtKB/TrEMBL
NCBI Gene	PRSS58	ENTREZGENE
PANTHER	RIKEN CDNA 2210010C04 GENE	UniProtKB/TrEMBL
	TRYPSIN-RELATED	UniProtKB/TrEMBL
Pfam	Trypsin	UniProtKB/TrEMBL
PRINTS	CHYMOTRYPSIN	UniProtKB/TrEMBL
PROSITE	TRYPSIN_DOM	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
SMART	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50494	UniProtKB/TrEMBL
UniProt	A0A0D9R6C6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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