Ctla2b (cytotoxic T lymphocyte-associated protein 2 beta) - Rat Genome Database

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Gene: Ctla2b (cytotoxic T lymphocyte-associated protein 2 beta) Mus musculus
Analyze
No known orthologs.
Symbol: Ctla2b
Name: cytotoxic T lymphocyte-associated protein 2 beta
RGD ID: 1624105
MGI Page MGI
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity. Is expressed in several structures, including blood; extraembryonic component; female reproductive system; and lung.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW545568; Ctla-; Ctla-2b; cytotoxic T lymphocyte-associated protein 2-beta; cytotoxic T-lymphocyte-associated protein 2-beta; protein CTLA-2-beta
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391361,043,165 - 61,045,269 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1361,043,164 - 61,045,261 (-)EnsemblGRCm39 Ensembl
GRCm381360,895,351 - 60,897,934 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1360,895,350 - 60,897,447 (-)EnsemblGRCm38mm10GRCm38
MGSCv371360,996,712 - 60,998,808 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1361,951,024 - 61,953,120 (-)NCBICelera
Cytogenetic Map13B2NCBI
cM Map1332.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2786470   PMID:10349636   PMID:10644441   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11829493   PMID:12466851   PMID:14681235   PMID:16141072   PMID:16141073  
PMID:16183747   PMID:21308776   PMID:21873635   PMID:27626380   PMID:28759565  


Genomics

Variants

.
Variants in Ctla2b
45 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:297
Count of miRNA genes:178
Interacting mature miRNAs:186
Transcripts:ENSMUST00000021884, ENSMUST00000171347
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
10401111Pgia40_mproteoglycan induced arthritis 40 (mouse)Not determined132791846961918560Mouse
1300710Pcd4ts2_mp-glycoprotein positive CD4 T cell subset 2 (mouse)Not determined132821044262210544Mouse
1357802Vtbt15_mvertebral trabecular bone trait 15 (mouse)Not determined132821737962217515Mouse
10045621Heal21_mwound healing/regeneration 21 (mouse)Not determined132821737962217515Mouse
10755533Chol18_mcholesterol 18 (mouse)133096946764969467Mouse
10755517Chol15_mcholesterol 15 (mouse)133096946764969467Mouse
12738439Twq4_mtestis weight QTL 4 (mouse)133112911065129110Mouse
14696729Kidlq2_mkidney weight, left QTL 2 (mouse)133134473665344736Mouse
1301299Sluc23_msusceptibility to lung cancer 23 (mouse)Not determined133492194368922081Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
1357587Pfat3_mpredicted fat percentage 3 (mouse)Not determined133610153070101640Mouse
1301734Acsns2_mAngiostrongylus costaricensis nematode susceptibility 2 (mouse)Not determined133610153070101640Mouse
1300561Heal7_mwound healing/regeneration 7 (mouse)Not determined133614482070144904Mouse
1300862Cfbw5_mcystic fibrosis body weight 5 (mouse)Not determined133872035872720517Mouse
1300985Bmd13_mbone mineral density 13 (mouse)Not determined133962924973629397Mouse
1302157Bwem2_mbody weight day 30 males 2 (mouse)Not determined133962924973629397Mouse
1301801Cpfd5_mcerebellum pattern fissures (mouse)Not determined133962924973629397Mouse
15039353Nmrs35_mNAFLD-associated magnetic resonance shift 35 (mouse)134058825374588253Mouse
1300668Pas10_mpulmonary adenoma susceptibility 10 (mouse)Not determined134148904275489158Mouse
4142331Bxs6_mBXSB/MpJ autoimmune nephritis 6 (mouse)Not determined4521044283744746Mouse
10412109Bxs7_mBXSB/MpJ autoimmune nephritis 7 (mouse)Not determined134521044283744746Mouse
26884396Humsd4_mhumerus midshaft diameter 4, 10 week (mouse)134785347673148119Mouse
4142372Moo2_mmodifier of Odc2 (mouse)Not determinedX5031841184318559Mouse
1301666Eae13_msusceptibility to experimental allergic encephalomyelitis 13 (mouse)Not determined135031841184318559Mouse
1300573Elsgp2_melevated serum gp70 2 (mouse)Not determined135061682884617027Mouse
14746975Manh74_mmandible shape 74 (mouse)135247726986477269Mouse
1302073Pgct1_mprimordial germ cell tumor locus 1 (mouse)Not determined135382078387820897Mouse
1357563Bmch6_mbone mechanical trait 6 (mouse)Not determined135538498089385140Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55720354112431103Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55720354112431103Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55720354112431103Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55720354112431103Mouse
1558850Sgp3_mserum gp70 production 3 (mouse)Not determined135647045676971314Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356470456105422186Mouse
1357553Cia28_mcollagen induced arthritis 28 (mouse)Not determined135662924996239162Mouse
10412163Wra1_mwheel running activity 1 (mouse)Not determined135913260093132738Mouse

Markers in Region
AW545568  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381360,896,099 - 60,896,302UniSTSGRCm38
GRCm381360,895,016 - 60,896,302UniSTSGRCm38
MGSCv371360,997,460 - 60,997,663UniSTSGRCm37
MGSCv371360,996,377 - 60,997,663UniSTSGRCm37
Celera1361,951,772 - 61,951,975UniSTS
Celera1361,950,689 - 61,951,975UniSTS
Cytogenetic Map12C1UniSTS
Whitehead/MRC_RH13637.51UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000021884   ⟹   ENSMUSP00000021884
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1361,043,169 - 61,045,261 (-)Ensembl
GRCm38.p6 Ensembl1360,895,355 - 60,897,447 (-)Ensembl
RefSeq Acc Id: ENSMUST00000171347   ⟹   ENSMUSP00000131083
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1361,043,176 - 61,045,219 (-)Ensembl
GRCm38.p6 Ensembl1360,895,362 - 60,897,405 (-)Ensembl
RefSeq Acc Id: ENSMUST00000225439   ⟹   ENSMUSP00000153559
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1361,043,164 - 61,044,867 (-)Ensembl
GRCm38.p6 Ensembl1360,895,350 - 60,897,053 (-)Ensembl
RefSeq Acc Id: ENSMUST00000225732   ⟹   ENSMUSP00000153260
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1361,043,165 - 61,044,100 (-)Ensembl
GRCm38.p6 Ensembl1360,895,351 - 60,896,286 (-)Ensembl
RefSeq Acc Id: NM_001145801   ⟹   NP_001139273
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391361,043,165 - 61,045,261 (-)NCBI
GRCm381360,895,351 - 60,897,447 (-)NCBI
MGSCv371260,996,712 - 60,998,808 (-)ENTREZGENE
Celera1361,951,024 - 61,953,120 (-)NCBI
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_007797   ⟹   NP_031823
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391361,043,165 - 61,045,261 (-)NCBI
GRCm381360,895,351 - 60,897,447 (-)NCBI
MGSCv371260,996,712 - 60,998,808 (-)ENTREZGENE
Celera1361,951,024 - 61,953,120 (-)NCBI
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011244472   ⟹   XP_011242774
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391361,043,174 - 61,045,215 (-)NCBI
GRCm381360,895,360 - 60,897,398 (-)NCBI
Sequence:
RefSeq Acc Id: XR_382421
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391361,043,174 - 61,045,269 (-)NCBI
GRCm381360,895,360 - 60,897,934 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_031823   ⟸   NM_007797
- Peptide Label: isoform a
- UniProtKB: Q3UBK9 (UniProtKB/Swiss-Prot),   Q541S2 (UniProtKB/Swiss-Prot),   P12400 (UniProtKB/Swiss-Prot),   A0A286YD17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001139273   ⟸   NM_001145801
- Peptide Label: isoform b
- UniProtKB: A0A0R4J245 (UniProtKB/TrEMBL),   A0A286YD17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011242774   ⟸   XM_011244472
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000153559   ⟸   ENSMUST00000225439
RefSeq Acc Id: ENSMUSP00000153260   ⟸   ENSMUST00000225732
RefSeq Acc Id: ENSMUSP00000131083   ⟸   ENSMUST00000171347
RefSeq Acc Id: ENSMUSP00000021884   ⟸   ENSMUST00000021884
Protein Domains
Cathepsin propeptide inhibitor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12400-F1-model_v2 AlphaFold P12400 1-113 view protein structure

Promoters
RGD ID:8680578
Promoter ID:EPDNEW_M18320
Type:initiation region
Name:Ctla2b_1
Description:Mus musculus cytotoxic T lymphocyte-associated protein 2 beta, transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381360,897,405 - 60,897,465EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88555 AgrOrtholog
Ensembl Genes ENSMUSG00000074874 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSMUSG00000114432 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021884 ENTREZGENE
  ENSMUST00000021884.10 UniProtKB/Swiss-Prot
  ENSMUST00000171347 ENTREZGENE
  ENSMUST00000171347.9 UniProtKB/TrEMBL
  ENSMUST00000225439.2 UniProtKB/TrEMBL
  ENSMUST00000225732.2 UniProtKB/TrEMBL
  ENSMUST00000225859.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.2250 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_inhib_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13025 UniProtKB/Swiss-Prot
MGD MGI:88555 ENTREZGENE
NCBI Gene 13025 ENTREZGENE
Pfam Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ctla2b PhenoGen
SMART Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J245 ENTREZGENE, UniProtKB/TrEMBL
  A0A286YD17 ENTREZGENE, UniProtKB/TrEMBL
  A0A286YD41_MOUSE UniProtKB/TrEMBL
  A0A286YE78_MOUSE UniProtKB/TrEMBL
  CTL2B_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UBK9 ENTREZGENE
  Q541S2 ENTREZGENE
UniProt Secondary Q3UBK9 UniProtKB/Swiss-Prot
  Q541S2 UniProtKB/Swiss-Prot