Dkkl1 (dickkopf-like 1) - Rat Genome Database

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Gene: Dkkl1 (dickkopf-like 1) Mus musculus
Analyze
Symbol: Dkkl1
Name: dickkopf-like 1
RGD ID: 1624042
MGI Page MGI
Description: Predicted to enable co-receptor binding activity and receptor antagonist activity. Involved in negative regulation of testosterone biosynthetic process; penetration of zona pellucida; and positive regulation of apoptotic process. Acts upstream of or within canonical Wnt signaling pathway and positive regulation of fat cell differentiation. Located in acrosomal vesicle. Is expressed in several structures, including extraembryonic component and reproductive system. Orthologous to human DKKL1 (dickkopf like acrosomal protein 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI414495; dickkopf-like protein 1; mSg; mSgy; protein soggy-1; SGY; SGY-; SGY-1; SGY1; Sog; Soggy; soggy 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,856,949 - 44,861,592 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,856,943 - 44,861,571 (-)EnsemblGRCm39 Ensembl
GRCm38745,207,525 - 45,212,165 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,207,519 - 45,212,147 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,462,895 - 52,467,253 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,075,567 - 45,079,892 (-)NCBIMGSCv36mm8
Celera740,663,416 - 40,667,775 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10570958   PMID:11024178   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12055200   PMID:12466851   PMID:12477932   PMID:14610273   PMID:14966277   PMID:15489334  
PMID:15892050   PMID:16141072   PMID:16141073   PMID:18818293   PMID:19176879   PMID:19596310   PMID:19596312   PMID:21677750   PMID:21698294   PMID:21873635   PMID:22817830   PMID:22967998  
PMID:23295900   PMID:24194600   PMID:27414999   PMID:29715368   PMID:38355793  


Genomics

Comparative Map Data
Dkkl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,856,949 - 44,861,592 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,856,943 - 44,861,571 (-)EnsemblGRCm39 Ensembl
GRCm38745,207,525 - 45,212,165 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,207,519 - 45,212,147 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,462,895 - 52,467,253 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,075,567 - 45,079,892 (-)NCBIMGSCv36mm8
Celera740,663,416 - 40,667,775 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.19NCBI
DKKL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,360,515 - 49,375,116 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,361,783 - 49,375,116 (+)EnsemblGRCh38hg38GRCh38
GRCh371949,867,134 - 49,878,373 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,558,854 - 54,570,185 (+)NCBINCBI36Build 36hg18NCBI36
Build 341954,558,853 - 54,570,183NCBI
Celera1946,733,898 - 46,745,228 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1946,243,555 - 46,254,943 (+)NCBIHuRef
CHM1_11949,868,966 - 49,880,350 (+)NCBICHM1_1
T2T-CHM13v2.01952,357,951 - 52,372,571 (+)NCBIT2T-CHM13v2.0
Dkkl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,830,462 - 104,835,711 (-)NCBIGRCr8
mRatBN7.2195,694,010 - 95,699,259 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,694,010 - 95,699,259 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,079,409 - 101,084,658 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,552,075 - 109,557,324 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,842,478 - 102,847,727 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,205,426 - 101,210,675 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,205,426 - 101,210,675 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,270,284 - 102,275,533 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,684,794 - 95,690,043 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera189,952,293 - 89,957,542 (-)NCBICelera
Cytogenetic Map1q22NCBI
Dkkl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,445,149 - 1,449,004 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,445,082 - 1,449,167 (-)NCBIChiLan1.0ChiLan1.0
DKKL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,479,696 - 55,493,609 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,398,633 - 57,413,230 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01946,375,301 - 46,389,822 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11955,300,173 - 55,313,690 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1955,301,955 - 55,313,690 (+)Ensemblpanpan1.1panPan2
DKKL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,109,787 - 107,113,932 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,109,791 - 107,113,811 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,693,253 - 106,697,206 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01107,630,262 - 107,634,229 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,630,266 - 107,634,131 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,303,172 - 107,307,137 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01106,945,347 - 106,949,315 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01107,786,470 - 107,790,436 (-)NCBIUU_Cfam_GSD_1.0
Dkkl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,638,880 - 21,645,597 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366643,257,698 - 3,264,565 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366643,257,744 - 3,263,787 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DKKL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,463,759 - 54,468,361 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,462,367 - 54,468,363 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DKKL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,544,459 - 42,555,653 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,547,593 - 42,555,566 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607322,470,364 - 22,482,443 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dkkl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248324,816,277 - 4,819,740 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248324,816,383 - 4,820,082 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dkkl1
118 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:150
Count of miRNA genes:144
Interacting mature miRNAs:149
Transcripts:ENSMUST00000033057
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72754054961540549Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301175Ap7q_malcohol preference 7 QTL (mouse)Not determined73171484565715077Mouse
1300996Aorls2_maortic lesion size 2 (mouse)Not determined73239453266394681Mouse
4142003W3q10_mweight 3 weeks QTL 10 (mouse)Not determined3349772758148965Mouse
4142102Tailq5_mtail length QTL 5 (mouse)Not determined3349772758148965Mouse
4142218W6q17_mweight 6 weeks QTL 17 (mouse)Not determined3349772758148965Mouse
4141909W10q18_mweight 10 weeks QTL 18 (mouse)Not determined3349772758148965Mouse
1357883Epfq5_mepididymal fat pad weight QTL 5 (mouse)Not determined73349772758148965Mouse
1357634Splq7_mspleen weight QTL 7 (mouse)Not determined73349772758148965Mouse
39128210Lwq19_mliver weight QTL 19 (mouse)73349772758148965Mouse
1357469Kidq5_mkidney weight QTL 5 (mouse)Not determined73349772758148965Mouse
1559000Ossc1_mosteosarcoma susceptibility 1 (mouse)Not determined73405302568053223Mouse
38501071Stsl6_mSalmonella typhimurium susceptibility locus 6 (mouse)73419942551149748Mouse
10045622Heal20_mwound healing/regeneration 20 (mouse)Not determined73431688768317043Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73444786968448018Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
25314301Vmm3_mvariable multisystem mineralization 3, lung (mouse)73729942572049748Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
1300878Skts1_mskin tumor susceptibility 1 (mouse)Not determined73789138671891582Mouse
10402488Dipa2_mdrug induced psychomotor activation 2 (mouse)Not determined73842154872421684Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74114882075148965Mouse
4141929Chlq18_mcirculating hormone level QTL 18 (mouse)Not determined74114882075148965Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000033057   ⟹   ENSMUSP00000033057
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl744,856,943 - 44,861,547 (-)Ensembl
GRCm38.p6 Ensembl745,207,519 - 45,212,123 (-)Ensembl
RefSeq Acc Id: ENSMUST00000209466   ⟹   ENSMUSP00000147489
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl744,857,049 - 44,861,247 (-)Ensembl
GRCm38.p6 Ensembl745,207,625 - 45,211,823 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210454
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl744,860,427 - 44,861,571 (-)Ensembl
GRCm38.p6 Ensembl745,211,003 - 45,212,147 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210741   ⟹   ENSMUSP00000147678
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl744,856,949 - 44,861,236 (-)Ensembl
GRCm38.p6 Ensembl745,207,525 - 45,211,812 (-)Ensembl
RefSeq Acc Id: NM_015789   ⟹   NP_056604
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39744,856,949 - 44,861,307 (-)NCBI
GRCm38745,207,525 - 45,211,883 (-)NCBI
MGSCv37752,462,895 - 52,467,253 (-)RGD
Celera740,663,416 - 40,667,775 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006540985   ⟹   XP_006541048
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39744,856,949 - 44,861,592 (-)NCBI
GRCm38745,207,525 - 45,212,165 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_056604   ⟸   NM_015789
- Peptide Label: precursor
- UniProtKB: Q9ERW0 (UniProtKB/Swiss-Prot),   Q9EQT4 (UniProtKB/Swiss-Prot),   Q9ERW1 (UniProtKB/Swiss-Prot),   Q9QZL9 (UniProtKB/Swiss-Prot),   Q3V2N2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006541048   ⟸   XM_006540985
- Peptide Label: isoform X1
- UniProtKB: A0A1B0GRV4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000147678   ⟸   ENSMUST00000210741
RefSeq Acc Id: ENSMUSP00000033057   ⟸   ENSMUST00000033057
RefSeq Acc Id: ENSMUSP00000147489   ⟸   ENSMUST00000209466

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZL9-F1-model_v2 AlphaFold Q9QZL9 1-230 view protein structure

Promoters
RGD ID:8663989
Promoter ID:EPDNEW_M10025
Type:initiation region
Name:Dkkl1_1
Description:Mus musculus dickkopf-like 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38745,211,861 - 45,211,921EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1354963 AgrOrtholog
Ensembl Genes ENSMUSG00000030792 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000033057 ENTREZGENE
  ENSMUST00000033057.9 UniProtKB/Swiss-Prot
  ENSMUST00000209466.2 UniProtKB/TrEMBL
  ENSMUST00000210741 ENTREZGENE
  ENSMUST00000210741.2 UniProtKB/TrEMBL
InterPro DKKL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:50722 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1354963 ENTREZGENE
NCBI Gene 50722 ENTREZGENE
PhenoGen Dkkl1 PhenoGen
UniProt A0A1B0GRE6_MOUSE UniProtKB/TrEMBL
  A0A1B0GRV4 ENTREZGENE, UniProtKB/TrEMBL
  DKKL1_MOUSE UniProtKB/Swiss-Prot
  Q3V2N2 ENTREZGENE, UniProtKB/TrEMBL
  Q9EQT4 ENTREZGENE
  Q9ERW0 ENTREZGENE
  Q9ERW1 ENTREZGENE
  Q9QZL9 ENTREZGENE
UniProt Secondary Q9EQT4 UniProtKB/Swiss-Prot
  Q9ERW0 UniProtKB/Swiss-Prot
  Q9ERW1 UniProtKB/Swiss-Prot