Klrg2 (killer cell lectin-like receptor subfamily G, member 2) - Rat Genome Database

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Gene: Klrg2 (killer cell lectin-like receptor subfamily G, member 2) Mus musculus
Analyze
Symbol: Klrg2
Name: killer cell lectin-like receptor subfamily G, member 2
RGD ID: 1623151
MGI Page MGI
Description: Predicted to enable carbohydrate binding activity. Predicted to be located in membrane. Orthologous to human KLRG2 (killer cell lectin like receptor G2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2310020F24Rik; killer cell lectin-like receptor subfamily G member 2
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39638,593,264 - 38,615,750 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl638,602,628 - 38,614,177 (-)EnsemblGRCm39 Ensembl
GRCm38638,616,329 - 38,638,815 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl638,625,693 - 38,637,242 (-)EnsemblGRCm38mm10GRCm38
MGSCv37638,576,660 - 38,587,239 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36638,556,268 - 38,566,841 (-)NCBIMGSCv36mm8
Celera638,607,614 - 38,618,192 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map617.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:16141072   PMID:16141073   PMID:32554809   PMID:38355793  


Genomics

Comparative Map Data
Klrg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39638,593,264 - 38,615,750 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl638,602,628 - 38,614,177 (-)EnsemblGRCm39 Ensembl
GRCm38638,616,329 - 38,638,815 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl638,625,693 - 38,637,242 (-)EnsemblGRCm38mm10GRCm38
MGSCv37638,576,660 - 38,587,239 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36638,556,268 - 38,566,841 (-)NCBIMGSCv36mm8
Celera638,607,614 - 38,618,192 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map617.85NCBI
KLRG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387139,427,098 - 139,483,673 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7139,452,690 - 139,483,673 (-)EnsemblGRCh38hg38GRCh38
GRCh377139,137,436 - 139,168,419 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367138,788,628 - 138,818,997 (-)NCBINCBI36Build 36hg18NCBI36
Celera7133,876,259 - 133,906,629 (-)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7133,447,971 - 133,478,537 (-)NCBIHuRef
CHM1_17139,072,282 - 139,102,632 (-)NCBICHM1_1
T2T-CHM13v2.07140,740,393 - 140,796,968 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27138,482,632 - 138,513,003 (-)NCBI
Klrg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8468,314,347 - 68,341,759 (-)NCBIGRCr8
mRatBN7.2467,360,216 - 67,374,867 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl467,363,919 - 67,374,147 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0466,370,674 - 66,381,351 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl466,371,511 - 66,380,734 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0466,181,601 - 66,192,056 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4466,199,037 - 66,208,260 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera462,381,539 - 62,392,214 (-)NCBICelera
Cytogenetic Map4q23NCBI
KLRG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26176,248,545 - 176,287,350 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1728,258,798 - 28,297,582 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07131,399,485 - 131,431,598 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17143,883,389 - 143,915,177 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7143,884,701 - 143,915,138 (-)Ensemblpanpan1.1panPan2
KLRG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1169,308,506 - 9,323,005 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1610,147,742 - 10,164,613 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0169,225,469 - 9,242,082 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl169,210,814 - 9,242,524 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1169,175,980 - 9,192,632 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0169,020,064 - 9,036,563 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0169,091,102 - 9,107,712 (+)NCBIUU_Cfam_GSD_1.0
Klrg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511815,479,380 - 15,494,787 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365923,725,016 - 3,740,262 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLRG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1810,213,758 - 10,234,121 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11810,213,477 - 10,233,562 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21810,699,741 - 10,719,654 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLRG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121108,197,801 - 108,235,999 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21108,198,147 - 108,235,749 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366615612,891 - 198,341 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klrg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476519,852,319 - 19,874,544 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Klrg2
548 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:398
Count of miRNA genes:288
Interacting mature miRNAs:313
Transcripts:ENSMUST00000096030
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
4141094Hrtr1_mheart rate 1 (mouse)Not determined3674146370741463Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3170349965703611Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63267698066676980Mouse
14746995Manh60_mmandible shape 60 (mouse)63720266271202662Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
1300767Aliq4_macute lung injury QTL 4 (mouse)Not determined63627333270273435Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63387226167872400Mouse
11252142Mom12_mModifier of Min 12 (mouse)63387226167872400Mouse
10043868Cia6b_mcollagen induced arthritis QTL 6b (mouse)Not determined63471159838946537Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
1357539Bsbob3_mBSB obesity 3 (mouse)Not determined63644845670448576Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2829099362291115Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3282758578215957Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000096030   ⟹   ENSMUSP00000093732
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl638,603,595 - 38,614,168 (-)Ensembl
GRCm38.p6 Ensembl638,626,660 - 38,637,233 (-)Ensembl
RefSeq Acc Id: ENSMUST00000201345   ⟹   ENSMUSP00000143835
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl638,604,196 - 38,614,177 (-)Ensembl
GRCm38.p6 Ensembl638,627,261 - 38,637,242 (-)Ensembl
RefSeq Acc Id: ENSMUST00000202245   ⟹   ENSMUSP00000144581
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl638,602,628 - 38,614,168 (-)Ensembl
GRCm38.p6 Ensembl638,625,693 - 38,637,233 (-)Ensembl
RefSeq Acc Id: NM_001033171   ⟹   NP_001028343
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39638,603,595 - 38,614,174 (-)NCBI
GRCm38638,626,660 - 38,637,239 (-)NCBI
MGSCv37638,576,660 - 38,587,239 (-)RGD
Celera638,607,614 - 38,618,192 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006506711   ⟹   XP_006506774
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39638,593,264 - 38,615,750 (-)NCBI
GRCm38638,616,329 - 38,638,815 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001028343   ⟸   NM_001033171
- UniProtKB: Q3UM83 (UniProtKB/Swiss-Prot),   Q3TE30 (UniProtKB/Swiss-Prot),   G5E8L6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006506774   ⟸   XM_006506711
- Peptide Label: isoform X1
- UniProtKB: Q3UM83 (UniProtKB/Swiss-Prot),   Q3TE30 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000144581   ⟸   ENSMUST00000202245
RefSeq Acc Id: ENSMUSP00000093732   ⟸   ENSMUST00000096030
RefSeq Acc Id: ENSMUSP00000143835   ⟸   ENSMUST00000201345
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3UM83-F1-model_v2 AlphaFold Q3UM83 1-387 view protein structure

Promoters
RGD ID:6839543
Promoter ID:MM_KWN:45638
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung
Transcripts:NM_001033171
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36638,586,556 - 38,587,507 (-)MPROMDB
RGD ID:6889370
Promoter ID:EPDNEW_M8136
Type:initiation region
Name:Klrg2_1
Description:Mus musculus killer cell lectin-like receptor subfamily G, member2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38638,637,242 - 38,637,302EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921503 AgrOrtholog
Ensembl Genes ENSMUSG00000071537 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000096030 ENTREZGENE
  ENSMUST00000096030.7 UniProtKB/TrEMBL
  ENSMUST00000201345.2 UniProtKB/TrEMBL
  ENSMUST00000202245.4 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KLRG2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NKR-like_CTLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:74253 UniProtKB/TrEMBL
MGD MGI:1921503 ENTREZGENE
NCBI Gene 74253 ENTREZGENE
PANTHER KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY G MEMBER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR47606 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klrg2 PhenoGen
PROSITE C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0J9YTT0_MOUSE UniProtKB/TrEMBL
  A0A0J9YVB2_MOUSE UniProtKB/TrEMBL
  G5E8L6 ENTREZGENE, UniProtKB/TrEMBL
  KLRG2_MOUSE UniProtKB/Swiss-Prot
  Q3TE30 ENTREZGENE
  Q3UM83 ENTREZGENE
UniProt Secondary Q3TE30 UniProtKB/Swiss-Prot