Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SEC16A mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | increases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of SEC16A mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | SEC16A (Homo sapiens) | 6480464 | ESR1 protein affects the reaction [Estradiol results in decreased expression of SEC16A mRNA] | CTD | PMID:15223131 | 17beta-estradiol | decreases expression | ISO | Sec16a (Rattus norvegicus) | 6480464 | Estradiol results in decreased expression of SEC16A mRNA | CTD | PMID:32145629 | 17beta-estradiol | decreases expression | ISO | SEC16A (Homo sapiens) | 6480464 | Estradiol results in decreased expression of SEC16A mRNA | CTD | PMID:15223131 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SEC16A mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Sec16a (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SEC16A mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Sec16a (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SEC16A mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of SEC16A mRNA | CTD | PMID:25975270 | 3-chloropropane-1,2-diol | increases expression | ISO | Sec16a (Rattus norvegicus) | 6480464 | alpha-Chlorohydrin results in increased expression of SEC16A protein | CTD | PMID:34915118 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | SEC16A (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SEC16A mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | decreases expression | EXP | | 6480464 | bisphenol S results in decreased expression of SEC16A mRNA | CTD | PMID:33297965 | acrolein | multiple interactions | ISO | SEC16A (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SEC16A mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of SEC16A mRNA | CTD | PMID:32699268 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of SEC16A mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases methylation | ISO | SEC16A (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of SEC16A exon and Aflatoxin B1 results in increased methylation of SEC16A gene | CTD | PMID:27153756 and PMID:30157460 | Aflatoxin B2 alpha | decreases methylation | ISO | SEC16A (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of SEC16A exon | CTD | PMID:30157460 | all-trans-retinoic acid | decreases expression | ISO | SEC16A (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of SEC16A mRNA | CTD | PMID:15498508 | alpha-pinene | multiple interactions | ISO | SEC16A (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SEC16A mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of SEC16A mRNA | CTD | PMID:32699268 | antirheumatic drug | decreases expression | ISO | SEC16A (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of SEC16A mRNA | CTD | PMID:24449571 | arsenous acid | decreases expression | EXP | | 6480464 | Arsenic Trioxide results in decreased expression of SEC16A mRNA | CTD | PMID:35676786 | benzene | increases expression | ISO | SEC16A (Homo sapiens) | 6480464 | Benzene results in increased expression of SEC16A mRNA | CTD | PMID:19162166 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | SEC16A (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | benzo[e]pyrene | decreases methylation | ISO | SEC16A (Homo sapiens) | 6480464 | benzo(e)pyrene results in decreased methylation of SEC16A exon | CTD | PMID:30157460 | bisphenol A | decreases expression | ISO | SEC16A (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of SEC16A mRNA and bisphenol A results in decreased expression of SEC16A protein | CTD | PMID:15223131 and PMID:34186270 | bisphenol A | decreases expression | ISO | Sec16a (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of SEC16A mRNA | CTD | PMID:32145629 | bisphenol A | affects expression | ISO | Sec16a (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of SEC16A mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | ISO | SEC16A (Homo sapiens) | 6480464 | ESR1 protein affects the reaction [bisphenol A results in decreased expression of SEC16A mRNA] | CTD | PMID:15223131 | Bisphenol B | increases expression | ISO | SEC16A (Homo sapiens) | 6480464 | bisphenol B results in increased expression of SEC16A protein | CTD | PMID:34186270 | bisphenol F | multiple interactions | ISO | SEC16A (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SEC16A mRNA | CTD | PMID:28628672 | bisphenol F | increases expression | ISO | SEC16A (Homo sapiens) | 6480464 | bisphenol F results in increased expression of SEC16A protein | CTD | PMID:34186270 | Brodifacoum | decreases expression | ISO | Sec16a (Rattus norvegicus) | 6480464 | bromfenacoum results in decreased expression of SEC16A protein | CTD | PMID:28903499 | cadmium atom | multiple interactions | ISO | SEC16A (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SEC16A mRNA | CTD | PMID:35301059 | cadmium dichloride | decreases expression | ISO | Sec16a (Rattus norvegicus) | 6480464 | Cadmium Chloride results in decreased expression of SEC16A mRNA | CTD | PMID:33453195 | cadmium dichloride | multiple interactions | ISO | SEC16A (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SEC16A mRNA | CTD | PMID:35301059 | caffeine | affects phosphorylation | ISO | SEC16A (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of SEC16A protein | CTD | PMID:35688186 | cisplatin | decreases expression | ISO | SEC16A (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of SEC16A mRNA | CTD | PMID:27594783 | copper(II) sulfate | increases expression | ISO | SEC16A (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of SEC16A mRNA | CTD | PMID:19549813 | coumarin | affects phosphorylation | ISO | SEC16A (Homo sapiens) | 6480464 | coumarin affects the phosphorylation of SEC16A protein | CTD | PMID:35688186 | cyclosporin A | increases expression | ISO | SEC16A (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of SEC16A mRNA | CTD | PMID:25562108 and PMID:27989131 | dexamethasone | multiple interactions | ISO | SEC16A (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SEC16A mRNA | CTD | PMID:28628672 | diarsenic trioxide | decreases expression | EXP | | 6480464 | Arsenic Trioxide results in decreased expression of SEC16A mRNA | CTD | PMID:35676786 | dicrotophos | increases expression | ISO | SEC16A (Homo sapiens) | 6480464 | dicrotophos results in increased expression of SEC16A mRNA | CTD | PMID:28302478 | doxorubicin | increases expression | ISO | SEC16A (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of SEC16A mRNA | CTD | PMID:29803840 | elemental selenium | decreases expression | ISO | SEC16A (Homo sapiens) | 6480464 | Selenium results in decreased expression of SEC16A mRNA | CTD | PMID:19244175 | endosulfan | increases expression | ISO | Sec16a (Rattus norvegicus) | 6480464 | Endosulfan results in increased expression of SEC16A mRNA | CTD | PMID:29391264 | enzyme inhibitor | multiple interactions | ISO | SEC16A (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SEC16A protein | CTD | PMID:23301498 | fenthion | decreases expression | EXP | | 6480464 | Fenthion results in decreased expression of SEC16A mRNA | CTD | PMID:34813904 | fluoranthene | multiple interactions | EXP | | 6480464 | [1-methylanthracene co-treated with fluoranthene] results in increased expression of SEC16A mRNA | CTD | PMID:28329830 | flutamide | increases expression | ISO | Sec16a (Rattus norvegicus) | 6480464 | Flutamide results in increased expression of SEC16A mRNA | CTD | PMID:24136188 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of SEC16A mRNA | CTD | PMID:25629700 | FR900359 | affects phosphorylation | ISO | SEC16A (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of SEC16A protein | CTD | PMID:37730182 | glafenine | increases expression | ISO | Sec16a (Rattus norvegicus) | 6480464 | Glafenine results in increased expression of SEC16A mRNA | CTD | PMID:24136188 | glyphosate | increases expression | EXP | | 6480464 | Glyphosate results in increased expression of SEC16A protein | CTD | PMID:36173347 | indometacin | multiple interactions | ISO | SEC16A (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SEC16A mRNA | CTD | PMID:28628672 | inulin | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of SEC16A mRNA | CTD | PMID:36331819 | ivermectin | decreases expression | ISO | SEC16A (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of SEC16A protein | CTD | PMID:32959892 | leflunomide | decreases expression | ISO | SEC16A (Homo sapiens) | 6480464 | leflunomide results in decreased expression of SEC16A mRNA | CTD | PMID:28988120 | methapyrilene | decreases methylation | ISO | SEC16A (Homo sapiens) | 6480464 | Methapyrilene results in decreased methylation of SEC16A exon | CTD | PMID:30157460 | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | decreases expression | ISO | SEC16A (Homo sapiens) | 6480464 | N more ... | CTD | PMID:12756304 | N-methyl-4-phenylpyridinium | increases expression | ISO | Sec16a (Rattus norvegicus) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of SEC16A mRNA | CTD | PMID:28801915 | ozone | multiple interactions | ISO | SEC16A (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SEC16A mRNA more ... | CTD | PMID:32699268 | paracetamol | decreases expression | ISO | SEC16A (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of SEC16A mRNA | CTD | PMID:21420995 | paracetamol | increases expression | ISO | Sec16a (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of SEC16A mRNA | CTD | PMID:33387578 | perfluorohexanesulfonic acid | decreases expression | EXP | | 6480464 | perfluorohexanesulfonic acid results in decreased expression of SEC16A mRNA | CTD | PMID:37995155 | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SEC16A mRNA and [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of SEC16A mRNA | CTD | PMID:36331819 | phenethyl isothiocyanate | increases expression | ISO | Sec16a (Rattus norvegicus) | 6480464 | phenethyl isothiocyanate results in increased expression of SEC16A mRNA | CTD | PMID:17616710 | phenobarbital | decreases expression | ISO | SEC16A (Homo sapiens) | 6480464 | Phenobarbital results in decreased expression of SEC16A protein | CTD | PMID:35881160 | phenobarbital | decreases expression | EXP | | 6480464 | Phenobarbital results in decreased expression of SEC16A protein | CTD | PMID:35881160 | potassium dichromate | increases expression | ISO | SEC16A (Homo sapiens) | 6480464 | Potassium Dichromate results in increased expression of SEC16A protein | CTD | PMID:23718831 | selenium atom | decreases expression | ISO | SEC16A (Homo sapiens) | 6480464 | Selenium results in decreased expression of SEC16A mRNA | CTD | PMID:19244175 | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of SEC16A mRNA | CTD | PMID:36209798 | sunitinib | increases expression | ISO | SEC16A (Homo sapiens) | 6480464 | Sunitinib results in increased expression of SEC16A mRNA | CTD | PMID:31533062 | tamibarotene | decreases expression | ISO | SEC16A (Homo sapiens) | 6480464 | tamibarotene results in decreased expression of SEC16A mRNA | CTD | PMID:15498508 | testosterone | decreases expression | EXP | | 6480464 | Testosterone deficiency results in decreased expression of SEC16A mRNA | CTD | PMID:33848595 | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of SEC16A mRNA | CTD | PMID:33045310 | tungsten | decreases expression | EXP | | 6480464 | Tungsten results in decreased expression of SEC16A mRNA | CTD | PMID:30912803 | valproic acid | increases methylation | ISO | SEC16A (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of SEC16A gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | SEC16A (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SEC16A mRNA | CTD | PMID:25979313 | vitamin E | decreases expression | ISO | SEC16A (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of SEC16A mRNA | CTD | PMID:19244175 | | 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