Defa5 (defensin, alpha, 5) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Defa5 (defensin, alpha, 5) Mus musculus
Analyze
No known orthologs.
Symbol: Defa5
Name: defensin, alpha, 5
RGD ID: 1622403
MGI Page MGI
Description: Predicted to enable pore-forming activity and protein homodimerization activity. Acts upstream of or within defense response to bacterium. Predicted to be located in midbody and secretory granule. Predicted to be active in extracellular space. Is expressed in ileum. Orthologous to several human genes including DEFA1 (defensin alpha 1); DEFA1B (defensin alpha 1B); and DEFA5 (defensin alpha 5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-defensin 5; Defa29; Defcr; Defcr29; Defcr5; defensin, alpha, 29; defensin-related cryptdin-5
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39821,787,410 - 21,788,391 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl821,787,455 - 21,788,391 (+)EnsemblGRCm39 Ensembl
GRCm38821,297,394 - 21,298,375 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl821,297,439 - 21,298,375 (+)EnsemblGRCm38mm10GRCm38
MGSCv37822,437,073 - 22,438,054 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36822,792,191 - 22,793,033 (+)NCBIMGSCv36mm8
Celera823,214,289 - 23,227,738 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map810.35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1500431   PMID:7927786   PMID:8188287   PMID:8760109   PMID:10569786   PMID:12477932   PMID:19394326   PMID:19855381   PMID:20003482   PMID:21873635   PMID:26015543   PMID:27760493  
PMID:32468660  


Genomics

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:137
Count of miRNA genes:131
Interacting mature miRNAs:134
Transcripts:ENSMUST00000098892
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124751082Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8495000035067154Mouse
1357525Pnhdlc3_mplasma non-HDL cholesterol 3 (mouse)Not determined8721249923753815Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8721249935110107Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
11532713Sluc42_msusceptibility to lung cancer 42 (mouse)81344721035321225Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
4142199Poats1_mpost-ovarectomy adrenal tumor susceptibility 1 (mouse)Not determined1708262628849467Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81945501853455150Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81945501853455150Mouse

Markers in Region
Defcr17  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37822,728,705 - 22,729,408UniSTSGRCm37
MGSCv37822,389,491 - 22,390,194UniSTSGRCm37
Celera821,017,916 - 21,018,626UniSTS
Cytogenetic Map8A2UniSTS
cM Map8 UniSTS
Defa1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8A2UniSTS
cM Map89.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000098892   ⟹   ENSMUSP00000096491
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl821,787,455 - 21,788,391 (+)Ensembl
GRCm38.p6 Ensembl821,297,439 - 21,298,375 (+)Ensembl
RefSeq Acc Id: NM_007851   ⟹   NP_031877
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39821,787,410 - 21,788,391 (+)NCBI
GRCm38821,297,394 - 21,298,375 (+)ENTREZGENE
MGSCv37822,437,073 - 22,438,054 (+)RGD
Celera823,214,289 - 23,227,738 (+)ENTREZGENE
cM Map8 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_031877 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA20973 (Get FASTA)   NCBI Sequence Viewer  
  AAA57173 (Get FASTA)   NCBI Sequence Viewer  
  AAB60678 (Get FASTA)   NCBI Sequence Viewer  
  AAI19611 (Get FASTA)   NCBI Sequence Viewer  
  EDL15555 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000096491
  ENSMUSP00000096491.5
GenBank Protein P28312 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_031877   ⟸   NM_007851
- Peptide Label: precursor
- UniProtKB: Q64382 (UniProtKB/Swiss-Prot),   P28312 (UniProtKB/Swiss-Prot),   L7N230 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000096491   ⟸   ENSMUST00000098892
Protein Domains
Mammalian defensins

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28312-F1-model_v2 AlphaFold P28312 1-93 view protein structure

Promoters
RGD ID:8666609
Promoter ID:EPDNEW_M11336
Type:single initiation site
Name:Defa5_1
Description:Mus musculus defensin, alpha, 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38821,297,396 - 21,297,456EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99583 AgrOrtholog
Ensembl Genes ENSMUSG00000074439 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000098892 ENTREZGENE
  ENSMUST00000098892.5 UniProtKB/TrEMBL
InterPro Alpha-defensin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha-defensin_pro UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Defensin_beta/alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Defensin_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13239 UniProtKB/TrEMBL
MGD MGI:99583 ENTREZGENE
NCBI Gene 13239 ENTREZGENE
PANTHER ALPHA-DEFENSIN 1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11876 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Defensin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Defensin_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Defa5 PhenoGen
PIRSF Alpha-defensin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DEFENSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Defensin_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEFSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Defensin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt DEFA5_MOUSE UniProtKB/Swiss-Prot
  L7N230 ENTREZGENE, UniProtKB/TrEMBL
  P28312 ENTREZGENE
  Q0VDM0_MOUSE UniProtKB/TrEMBL
  Q64382 ENTREZGENE
UniProt Secondary Q64382 UniProtKB/Swiss-Prot