Fbxw20 (F-box and WD-40 domain protein 20) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Fbxw20 (F-box and WD-40 domain protein 20) Mus musculus
Analyze
No known orthologs.
Symbol: Fbxw20
Name: F-box and WD-40 domain protein 20
RGD ID: 1621876
MGI Page MGI
Description: Predicted to be active in cytoplasm. Orthologous to human FBXW12 (F-box and WD repeat domain containing 12).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: F-box and WD-40 domain protein 12; Fbxw12; MGC103250
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399109,046,500 - 109,063,822 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9109,046,500 - 109,063,822 (-)EnsemblGRCm39 Ensembl
GRCm389109,217,432 - 109,234,754 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9109,217,432 - 109,234,754 (-)EnsemblGRCm38mm10GRCm38
MGSCv379109,119,946 - 109,137,238 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369109,074,838 - 109,092,135 (-)NCBIMGSCv36mm8
Celera9108,776,189 - 108,793,488 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15520277   PMID:16141072   PMID:16141073   PMID:21873635   PMID:38355793  


Genomics

Variants

.
Variants in Fbxw20
499 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:424
Count of miRNA genes:322
Interacting mature miRNAs:340
Transcripts:ENSMUST00000079548, ENSMUST00000125062, ENSMUST00000125706
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959897283109089068Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975682646114303447Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975682646114303447Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976417989110418183Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978522698112522808Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979279863113279941Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981680321115680445Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982792386116792481Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982792386116792481Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982792386116792481Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984406017118406120Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986107600120107729Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986121898120118690Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986625682120625682Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987677199121677199Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989162124123162124Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989289476123289595Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989440541123440541Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989859058118767089Mouse
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994863354112701997Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9100889929124359700Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9101829255124359700Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9101829255124359700Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103118511124359700Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103118511124359700Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103118511124359700Mouse
13515058Adip20d_madiposity 20d (mouse)9108744078118744078Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000079548   ⟹   ENSMUSP00000078503
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9109,046,500 - 109,063,822 (-)Ensembl
GRCm38.p6 Ensembl9109,217,432 - 109,234,754 (-)Ensembl
RefSeq Acc Id: ENSMUST00000197329   ⟹   ENSMUSP00000143126
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9109,050,879 - 109,063,792 (-)Ensembl
GRCm38.p6 Ensembl9109,221,811 - 109,234,724 (-)Ensembl
RefSeq Acc Id: ENSMUST00000198261
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9109,049,411 - 109,063,801 (-)Ensembl
GRCm38.p6 Ensembl9109,220,343 - 109,234,733 (-)Ensembl
RefSeq Acc Id: NM_001008428   ⟹   NP_001008428
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399109,046,500 - 109,063,822 (-)NCBI
GRCm389109,217,432 - 109,234,754 (-)NCBI
MGSCv379109,119,946 - 109,137,238 (-)RGD
Celera9108,776,189 - 108,793,511 (-)NCBI
cM Map9 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001008428 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85247 (Get FASTA)   NCBI Sequence Viewer  
  BAE22662 (Get FASTA)   NCBI Sequence Viewer  
  BAE22872 (Get FASTA)   NCBI Sequence Viewer  
  EDL21348 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000078503
  ENSMUSP00000078503.7
  ENSMUSP00000143126.2
Reference Protein Sequences
RefSeq Acc Id: NP_001008428   ⟸   NM_001008428
- UniProtKB: Q5U467 (UniProtKB/TrEMBL),   Q3UXA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000143126   ⟸   ENSMUST00000197329
RefSeq Acc Id: ENSMUSP00000078503   ⟸   ENSMUST00000079548
Protein Domains
F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U467-F1-model_v2 AlphaFold Q5U467 1-468 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3584372 AgrOrtholog
Ensembl Genes ENSMUSG00000061701 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000079548 ENTREZGENE
  ENSMUST00000079548.12 UniProtKB/TrEMBL
  ENSMUST00000197329.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1280.50 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
InterPro F-box_dom_cyclin-like UniProtKB/TrEMBL
  F-box_dom_like UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report mmu:434440 UniProtKB/TrEMBL
MGD MGI:3584372 ENTREZGENE
NCBI Gene 434440 ENTREZGENE
PANTHER EXPRESSED SEQUENCE C85627-RELATED UniProtKB/TrEMBL
  F-BOX ONLY PROTEIN 3 UniProtKB/TrEMBL
Pfam F-box-like UniProtKB/TrEMBL
PhenoGen Fbxw20 PhenoGen
PROSITE FBOX UniProtKB/TrEMBL
SMART FBOX UniProtKB/TrEMBL
Superfamily-SCOP F-box_dom_Skp2-like UniProtKB/TrEMBL
  WD40_like UniProtKB/TrEMBL
UniProt A0A0G2JFD2_MOUSE UniProtKB/TrEMBL
  Q3UXA1 ENTREZGENE, UniProtKB/TrEMBL
  Q5U467 ENTREZGENE, UniProtKB/TrEMBL