Krt35 (keratin 35) - Rat Genome Database

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Gene: Krt35 (keratin 35) Mus musculus
Analyze
Symbol: Krt35
Name: keratin 35
RGD ID: 1621558
MGI Page MGI
Description: Predicted to enable structural molecule activity. Predicted to be involved in epithelial cell differentiation and intermediate filament organization. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Is expressed in filiform papillae; skin; and tongue. Orthologous to human KRT35 (keratin 35).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI662400; Ha; Ha5; hair keratin acidic 5; hair keratin, type I Ha5; K35; keratin complex 1, acidic, gene 24; keratin complex 1, gene 24; keratin, hair, acidic, 5; keratin, type I cuticular Ha5; keratin-35; Krt1-2; Krt1-24; Krtha5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391199,983,018 - 99,987,050 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1199,983,019 - 99,987,067 (-)EnsemblGRCm39 Ensembl
GRCm3811100,092,192 - 100,096,224 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,092,193 - 100,096,241 (-)EnsemblGRCm38mm10GRCm38
MGSCv371199,953,506 - 99,957,538 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361199,908,288 - 99,912,315 (-)NCBIMGSCv36mm8
Celera11110,708,544 - 110,712,607 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15454262   PMID:16141072   PMID:16141073   PMID:16510873   PMID:16831889  
PMID:18021261   PMID:18684741   PMID:19470461   PMID:21267068   PMID:21565611   PMID:21873635   PMID:27234308   PMID:27287879   PMID:32325033  


Genomics

Comparative Map Data
Krt35
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391199,983,018 - 99,987,050 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1199,983,019 - 99,987,067 (-)EnsemblGRCm39 Ensembl
GRCm3811100,092,192 - 100,096,224 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,092,193 - 100,096,241 (-)EnsemblGRCm38mm10GRCm38
MGSCv371199,953,506 - 99,957,538 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361199,908,288 - 99,912,315 (-)NCBIMGSCv36mm8
Celera11110,708,544 - 110,712,607 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.4NCBI
KRT35
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381741,476,710 - 41,481,151 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1741,476,710 - 41,481,151 (-)EnsemblGRCh38hg38GRCh38
GRCh371739,632,962 - 39,637,403 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361736,886,467 - 36,890,918 (-)NCBINCBI36Build 36hg18NCBI36
Build 341736,886,466 - 36,891,194NCBI
Celera1736,286,163 - 36,290,612 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1735,396,551 - 35,401,000 (-)NCBIHuRef
CHM1_11739,868,249 - 39,872,698 (-)NCBICHM1_1
T2T-CHM13v2.01742,332,251 - 42,336,690 (-)NCBIT2T-CHM13v2.0
Krt35
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81085,526,571 - 85,529,968 (-)NCBIGRCr8
mRatBN7.21085,026,171 - 85,029,568 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,026,171 - 85,029,568 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,044,470 - 90,047,872 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01089,542,524 - 89,545,921 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01084,934,476 - 84,937,873 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,006,179 - 88,009,576 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,006,179 - 88,009,576 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01087,798,389 - 87,801,786 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,031,289 - 89,034,686 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,045,658 - 89,049,056 (-)NCBI
Celera1083,745,827 - 83,749,224 (-)NCBICelera
Cytogenetic Map10q31NCBI
Krt35
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545115,820,687 - 15,824,284 (-)NCBIChiLan1.0ChiLan1.0
KRT35
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21923,503,780 - 23,508,142 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11725,393,755 - 25,398,117 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,835,732 - 15,840,115 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11716,053,166 - 16,057,533 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1716,053,166 - 16,057,533 (+)Ensemblpanpan1.1panPan2
KRT35
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1921,286,925 - 21,292,699 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl921,287,584 - 21,292,339 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,748,716 - 20,754,485 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0922,007,866 - 22,013,640 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl922,007,925 - 22,013,645 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,793,869 - 20,799,638 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0921,059,892 - 21,065,658 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0921,163,698 - 21,169,463 (+)NCBIUU_Cfam_GSD_1.0
KRT35
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1221,166,484 - 21,171,915 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11221,166,366 - 21,171,894 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21221,447,219 - 21,452,620 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KRT35
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,759,441 - 64,764,085 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1664,760,395 - 64,764,422 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607735,605,267 - 35,609,697 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Krt35
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247952,125,658 - 2,128,783 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247952,125,658 - 2,128,783 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Krt35
109 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:467
Count of miRNA genes:348
Interacting mature miRNAs:395
Transcripts:ENSMUST00000103127, ENSMUST00000173988
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
13513918Heal55_mwound healing/ regeneration 55 (mouse)1199672251100232454Mouse

Markers in Region
AI662400  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811100,092,333 - 100,092,422UniSTSGRCm38
MGSCv371199,953,647 - 99,953,736UniSTSGRCm37
Celera11110,708,685 - 110,708,774UniSTS
Cytogenetic Map11DUniSTS
Whitehead/MRC_RH111330.57UniSTS
Krt35  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811100,092,331 - 100,092,423UniSTSGRCm38
Celera11110,708,683 - 110,708,775UniSTS
Cytogenetic Map11DUniSTS
cM Map1163.4UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000103127   ⟹   ENSMUSP00000099416
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1199,983,019 - 99,987,051 (-)Ensembl
GRCm38.p6 Ensembl11100,092,193 - 100,096,225 (-)Ensembl
RefSeq Acc Id: ENSMUST00000173988
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1199,983,021 - 99,987,067 (-)Ensembl
GRCm38.p6 Ensembl11100,092,195 - 100,096,241 (-)Ensembl
RefSeq Acc Id: NM_016880   ⟹   NP_058576
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391199,983,018 - 99,987,050 (-)NCBI
GRCm3811100,092,192 - 100,096,224 (-)ENTREZGENE
MGSCv371199,953,506 - 99,957,538 (-)RGD
Celera11110,708,544 - 110,712,607 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_058576 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD01693 (Get FASTA)   NCBI Sequence Viewer  
  AAI00543 (Get FASTA)   NCBI Sequence Viewer  
  AAI40966 (Get FASTA)   NCBI Sequence Viewer  
  EDL02581 (Get FASTA)   NCBI Sequence Viewer  
  EDL02582 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000099416
  ENSMUSP00000099416.4
GenBank Protein Q497I4 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_058576   ⟸   NM_016880
- UniProtKB: B2RU48 (UniProtKB/Swiss-Prot),   Q9Z2T8 (UniProtKB/Swiss-Prot),   Q497I4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000099416   ⟸   ENSMUST00000103127
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q497I4-F1-model_v2 AlphaFold Q497I4 1-455 view protein structure

Promoters
RGD ID:8676656
Promoter ID:EPDNEW_M16359
Type:multiple initiation site
Name:Krt35_1
Description:Mus musculus keratin 35 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811100,096,239 - 100,096,299EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1858899 AgrOrtholog
Ensembl Genes ENSMUSG00000048013 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000103127 ENTREZGENE
  ENSMUST00000103127.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  Single helix bin UniProtKB/Swiss-Prot
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot
InterPro IF_conserved UniProtKB/Swiss-Prot
  IF_rod_dom UniProtKB/Swiss-Prot
  Keratin_I UniProtKB/Swiss-Prot
KEGG Report mmu:53617 UniProtKB/Swiss-Prot
MGD MGI:1858899 ENTREZGENE
NCBI Gene 53617 ENTREZGENE
PANTHER KERATIN, TYPE I CUTICULAR HA5 UniProtKB/Swiss-Prot
  PTHR23239 UniProtKB/Swiss-Prot
Pfam Filament UniProtKB/Swiss-Prot
PhenoGen Krt35 PhenoGen
PRINTS TYPE1KERATIN UniProtKB/Swiss-Prot
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot
  IF_ROD_2 UniProtKB/Swiss-Prot
SMART Filament UniProtKB/Swiss-Prot
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot
UniProt B2RU48 ENTREZGENE
  KRT35_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q9Z2T8 ENTREZGENE
UniProt Secondary B2RU48 UniProtKB/Swiss-Prot
  Q9Z2T8 UniProtKB/Swiss-Prot