Defb11 (defensin beta 11) - Rat Genome Database

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Gene: Defb11 (defensin beta 11) Mus musculus
Analyze
No known orthologs.
Symbol: Defb11
Name: defensin beta 11
RGD ID: 1621280
MGI Page MGI
Description: Predicted to enable CCR6 chemokine receptor binding activity. Predicted to be involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and innate immune response in mucosa. Predicted to act upstream of or within defense response to bacterium. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in central nervous system and retina.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BD-11; beta-defensin 11; Defb8; defensin, beta 11; mBD-11
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39822,395,383 - 22,396,448 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl822,395,392 - 22,396,428 (-)EnsemblGRCm39 Ensembl
GRCm38821,905,374 - 21,906,432 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl821,905,376 - 21,906,412 (-)EnsemblGRCm38mm10GRCm38
MGSCv37823,015,846 - 23,016,904 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36823,370,933 - 23,371,956 (-)NCBIMGSCv36mm8
Celera823,395,802 - 23,396,803 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map810.59NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11854508   PMID:12193721   PMID:12477932   PMID:12644567   PMID:16141072   PMID:16602821   PMID:20003482   PMID:21677750   PMID:21873635  


Genomics

Variants

.
Variants in Defb11
36 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:69
Interacting mature miRNAs:76
Transcripts:ENSMUST00000051965
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124751082Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8495000035067154Mouse
1357525Pnhdlc3_mplasma non-HDL cholesterol 3 (mouse)Not determined8721249923753815Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8721249935110107Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
11532713Sluc42_msusceptibility to lung cancer 42 (mouse)81344721035321225Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
4142199Poats1_mpost-ovarectomy adrenal tumor susceptibility 1 (mouse)Not determined1708262628849467Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81945501853455150Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81945501853455150Mouse

Markers in Region
UniSTS:485049  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38821,905,407 - 21,906,400UniSTSGRCm38
MGSCv37823,015,879 - 23,016,872UniSTSGRCm37
Celera823,395,835 - 23,396,769UniSTS
Cytogenetic Map8A2UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000051965   ⟹   ENSMUSP00000053932
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl822,395,392 - 22,396,428 (-)Ensembl
GRCm38.p6 Ensembl821,905,376 - 21,906,412 (-)Ensembl
RefSeq Acc Id: NM_139221   ⟹   NP_631967
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39822,395,383 - 22,396,448 (-)NCBI
GRCm38821,905,374 - 21,906,432 (-)ENTREZGENE
MGSCv37823,015,846 - 23,016,904 (-)RGD
Celera823,395,802 - 23,396,803 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_631967 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH99849 (Get FASTA)   NCBI Sequence Viewer  
  CAD26895 (Get FASTA)   NCBI Sequence Viewer  
  EDL32918 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000053932
  ENSMUSP00000053932.5
GenBank Protein Q8R2I7 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_631967   ⟸   NM_139221
- Peptide Label: precursor
- UniProtKB: Q499L3 (UniProtKB/Swiss-Prot),   Q8R2I7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000053932   ⟸   ENSMUST00000051965

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R2I7-F1-model_v2 AlphaFold Q8R2I7 1-77 view protein structure

Promoters
RGD ID:8666641
Promoter ID:EPDNEW_M11351
Type:initiation region
Name:Defb11_1
Description:Mus musculus defensin beta 11 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38821,906,432 - 21,906,492EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2179197 AgrOrtholog
Ensembl Genes ENSMUSG00000045337 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000051965 ENTREZGENE
  ENSMUST00000051965.5 UniProtKB/Swiss-Prot
InterPro Defensin_beta-typ UniProtKB/Swiss-Prot
KEGG Report mmu:246081 UniProtKB/Swiss-Prot
MGD MGI:2179197 ENTREZGENE
NCBI Gene 246081 ENTREZGENE
PANTHER BETA-DEFENSIN 10-RELATED UniProtKB/Swiss-Prot
  BETA-DEFENSIN-RELATED UniProtKB/Swiss-Prot
Pfam Defensin_beta UniProtKB/Swiss-Prot
PhenoGen Defb11 PhenoGen
Superfamily-SCOP Defensin-like UniProtKB/Swiss-Prot
UniProt DFB11_MOUSE UniProtKB/Swiss-Prot
  Q499L3 ENTREZGENE
  Q8R2I7 ENTREZGENE
UniProt Secondary Q499L3 UniProtKB/Swiss-Prot