Defa42 (defensin, alpha, 42) - Rat Genome Database

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Gene: Defa42 (defensin, alpha, 42) Mus musculus
Analyze
No known orthologs.
Symbol: Defa42
Name: defensin, alpha, 42
RGD ID: 1621021
MGI Page MGI
Description: Predicted to enable protein homodimerization activity. Predicted to be involved in cellular response to lipopolysaccharide; defense response to other organism; and disruption of plasma membrane integrity in another organism. Predicted to be located in azurophil granule. Predicted to be active in extracellular space. Orthologous to human DEFA4 (defensin alpha 4) and DEFA6 (defensin alpha 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-defensin 42; EG665927; Gm7849; novel defensin-related cryptidin; predicted gene 7849; predicted gene, EG665927
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39821,945,443 - 21,946,533 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl821,945,461 - 21,946,576 (-)EnsemblGRCm39 Ensembl
GRCm38821,455,427 - 21,456,517 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl821,455,445 - 21,456,560 (-)EnsemblGRCm38mm10GRCm38
MGSCv37822,565,899 - 22,566,989 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36822,920,972 - 22,922,107 (-)NCBIMGSCv36mm8
Celera821,795,408 - 21,796,498 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map810.35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20003482   PMID:21873635  


Genomics

Variants

.
Variants in Defa42
30 total Variants

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124751082Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8495000035067154Mouse
1357525Pnhdlc3_mplasma non-HDL cholesterol 3 (mouse)Not determined8721249923753815Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8721249935110107Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
11532713Sluc42_msusceptibility to lung cancer 42 (mouse)81344721035321225Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
4142199Poats1_mpost-ovarectomy adrenal tumor susceptibility 1 (mouse)Not determined1708262628849467Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81945501853455150Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81945501853455150Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000110752   ⟹   ENSMUSP00000106380
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl821,945,461 - 21,946,576 (-)Ensembl
GRCm38.p6 Ensembl821,455,445 - 21,456,560 (-)Ensembl
RefSeq Acc Id: NM_001177518   ⟹   NP_001170989
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39821,945,443 - 21,946,533 (-)NCBI
GRCm38821,455,427 - 21,456,517 (-)ENTREZGENE
MGSCv37822,565,899 - 22,566,989 (-)RGD
Celera821,795,408 - 21,796,498 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001170989 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000106377.4
  ENSMUSP00000106380
  ENSMUSP00000106380.4
Reference Protein Sequences
RefSeq Acc Id: NP_001170989   ⟸   NM_001177518
- Peptide Label: precursor
- UniProtKB: Q9QVW7 (UniProtKB/Swiss-Prot),   P17533 (UniProtKB/Swiss-Prot),   D3YX03 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000106380   ⟸   ENSMUST00000110752
Protein Domains
Alpha-defensin N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3YX03-F1-model_v2 AlphaFold D3YX03 1-116 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3645033 AgrOrtholog
Ensembl Genes ENSMUSG00000079113 UniProtKB/TrEMBL
  ENSMUSG00000079114 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000110749.4 UniProtKB/TrEMBL
  ENSMUST00000110752 ENTREZGENE
  ENSMUST00000110752.4 UniProtKB/TrEMBL
InterPro Alpha-defensin UniProtKB/TrEMBL
  Defensin_propep UniProtKB/TrEMBL
KEGG Report mmu:665927 UniProtKB/TrEMBL
  mmu:665956 UniProtKB/TrEMBL
MGD MGI:3645033 ENTREZGENE
NCBI Gene 665927 ENTREZGENE
PANTHER ALPHA-DEFENSIN 1-RELATED UniProtKB/TrEMBL
  PTHR11876 UniProtKB/TrEMBL
Pfam Defensin_propep UniProtKB/TrEMBL
PhenoGen Defa42 PhenoGen
PIRSF Alpha-defensin UniProtKB/TrEMBL
SMART Defensin_propep UniProtKB/TrEMBL
UniProt D3YX03 ENTREZGENE, UniProtKB/TrEMBL
  P17533 ENTREZGENE
  Q9QVW7 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-20 Defa42  defensin, alpha, 42  Gm7849  predicted gene 7849  Symbol and/or name change 5135510 APPROVED