Ear4 (eosinophil-associated, ribonuclease A family, member 4) - Rat Genome Database

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Gene: Ear4 (eosinophil-associated, ribonuclease A family, member 4) Mus musculus
Analyze
No known orthologs.
Symbol: Ear4
Name: eosinophil-associated, ribonuclease A family, member 4
RGD ID: 1620073
MGI Page MGI
Description: Predicted to enable RNA nuclease activity. Predicted to be involved in chemotaxis; defense response to Gram-positive bacterium; and innate immune response in mucosa. Predicted to be located in lysosome. Predicted to be active in extracellular space. Orthologous to human RNASE2 (ribonuclease A family member 2) and RNASE3 (ribonuclease A family member 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: eosinophil cationic-type ribonuclease 4; eosinophil-associated ribonuclease 4; liver, eosinophil-derived neurotoxin; mR; MR-4; mR4; murine ribonuclease 4; non-secretory ribonuclease; ribonuclease 2; ribonuclease 4; ribonuclease, RNase A family, 2; RNase 2; Rnase2; RNS2
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
NCBI Annotation Information: Genome Annotation Status: not in current annotation release
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381443,901,680 - 43,902,141 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371450,125,641 - 50,126,107 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361450,125,641 - 50,126,107 (+)NCBIMGSCv36mm8
Celera1447,503,714 - 47,504,180 (+)NCBICelera
Cytogenetic Map14C1NCBI


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
extracellular space  (IBA,ISO)
lysosome  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9336452   PMID:12466851   PMID:15058383   PMID:15676279   PMID:21873635  


Genomics


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001017422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF017259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: NM_001017422   ⟹   NP_001017422
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381443,901,680 - 43,902,141 (-)ENTREZGENE
MGSCv371450,125,641 - 50,126,107 (+)RGD
Celera1447,503,714 - 47,504,180 (+)RGD
cM Map14 ENTREZGENE
Protein Sequences
Protein RefSeqs NP_001017422 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53490 (Get FASTA)   NCBI Sequence Viewer  
  O35291 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001017422   ⟸   NM_001017422
- Peptide Label: precursor
- UniProtKB: O35291 (UniProtKB/Swiss-Prot),   F6YUX7 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35291-F1-model_v2 AlphaFold O35291 1-155 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1858238 AgrOrtholog
Gene3D-CATH 3.10.130.10 UniProtKB/Swiss-Prot
InterPro RNaseA UniProtKB/Swiss-Prot
  RNaseA-like_dom_sf UniProtKB/Swiss-Prot
  RNaseA_AS UniProtKB/Swiss-Prot
  RNaseA_domain UniProtKB/Swiss-Prot
KEGG Report mmu:53877 UniProtKB/Swiss-Prot
MGD MGI:1858238 ENTREZGENE
NCBI Gene 53877 ENTREZGENE
PANTHER EOSINOPHIL CATIONIC PROTEIN UniProtKB/Swiss-Prot
  PTHR11437 UniProtKB/Swiss-Prot
Pfam RnaseA UniProtKB/Swiss-Prot
PhenoGen Ear4 PhenoGen
PRINTS RIBONUCLEASE UniProtKB/Swiss-Prot
PROSITE RNASE_PANCREATIC UniProtKB/Swiss-Prot
SMART RNAse_Pc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54076 UniProtKB/Swiss-Prot
UniProt F6YUX7 ENTREZGENE
  O35291 ENTREZGENE, UniProtKB/Swiss-Prot