Mrgpra4 (MAS-related GPR, member A4) - Rat Genome Database

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Gene: Mrgpra4 (MAS-related GPR, member A4) Mus musculus
Analyze
No known orthologs.
Symbol: Mrgpra4
Name: MAS-related GPR, member A4
RGD ID: 1619827
MGI Page MGI
Description: Enables neuropeptide receptor activity. Acts upstream of or within neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human MRGPRX4 (MAS related GPR family member X4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Mas-related G protein-coupled receptor g10; mas-related G-protein coupled receptor member A4; Mgrg10; Mrg; MrgA4; MrgA4 RF-amide G protein-coupled receptor; RF-amide G-protein coupled receptor
RGD Orthologs
Alliance Genes
More Info homologs ...
Related Pseudogenes: Gm18349   Gm18351   Gm18352   Gm2707   Gm5733   Gm5734   Gm9717   Mrgpra18-ps  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39747,630,542 - 47,632,044 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl747,630,585 - 47,631,843 (-)EnsemblGRCm39 Ensembl
GRCm38747,980,794 - 47,982,296 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl747,980,837 - 47,982,095 (-)EnsemblGRCm38mm10GRCm38
MGSCv37755,236,164 - 55,237,666 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36747,848,816 - 47,850,318 (-)NCBIMGSCv36mm8
Celera743,437,388 - 43,438,890 (-)NCBICelera
Cytogenetic Map7B4NCBI
cM Map731.08NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11551509   PMID:12397184   PMID:12477932   PMID:12909716   PMID:17553423   PMID:21873635   PMID:24583173  


Genomics

Variants

.
Variants in Mrgpra4
197 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:211
Count of miRNA genes:205
Interacting mature miRNAs:210
Transcripts:ENSMUST00000087092
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72754054961540549Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301175Ap7q_malcohol preference 7 QTL (mouse)Not determined73171484565715077Mouse
1300996Aorls2_maortic lesion size 2 (mouse)Not determined73239453266394681Mouse
4142003W3q10_mweight 3 weeks QTL 10 (mouse)Not determined3349772758148965Mouse
4142102Tailq5_mtail length QTL 5 (mouse)Not determined3349772758148965Mouse
4142218W6q17_mweight 6 weeks QTL 17 (mouse)Not determined3349772758148965Mouse
4141909W10q18_mweight 10 weeks QTL 18 (mouse)Not determined3349772758148965Mouse
1357883Epfq5_mepididymal fat pad weight QTL 5 (mouse)Not determined73349772758148965Mouse
1357634Splq7_mspleen weight QTL 7 (mouse)Not determined73349772758148965Mouse
39128210Lwq19_mliver weight QTL 19 (mouse)73349772758148965Mouse
1357469Kidq5_mkidney weight QTL 5 (mouse)Not determined73349772758148965Mouse
1559000Ossc1_mosteosarcoma susceptibility 1 (mouse)Not determined73405302568053223Mouse
38501071Stsl6_mSalmonella typhimurium susceptibility locus 6 (mouse)73419942551149748Mouse
10045622Heal20_mwound healing/regeneration 20 (mouse)Not determined73431688768317043Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73444786968448018Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
25314301Vmm3_mvariable multisystem mineralization 3, lung (mouse)73729942572049748Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
1300878Skts1_mskin tumor susceptibility 1 (mouse)Not determined73789138671891582Mouse
10402488Dipa2_mdrug induced psychomotor activation 2 (mouse)Not determined73842154872421684Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74114882075148965Mouse
4141929Chlq18_mcirculating hormone level QTL 18 (mouse)Not determined74114882075148965Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
12880417V125Dq5_mvitamin D active form serum level QTL 5 (mouse)74524974879249748Mouse
25314304Vmm1_mvariable multisystem mineralization 1, muzzle (mouse)74714974856549748Mouse
25314302Vmm2_mvariable multisystem mineralization 2, heart (mouse)74714974874149748Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000087092   ⟹   ENSMUSP00000084327
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl747,630,585 - 47,631,843 (-)Ensembl
GRCm38.p6 Ensembl747,980,837 - 47,982,095 (-)Ensembl
RefSeq Acc Id: NM_153524   ⟹   NP_705744
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39747,630,542 - 47,632,044 (-)NCBI
GRCm38747,980,794 - 47,982,296 (-)ENTREZGENE
MGSCv37755,236,164 - 55,237,666 (-)RGD
Celera743,437,388 - 43,438,890 (-)RGD
cM Map7 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_705744 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI15742 (Get FASTA)   NCBI Sequence Viewer  
  AAI45572 (Get FASTA)   NCBI Sequence Viewer  
  AAI45574 (Get FASTA)   NCBI Sequence Viewer  
  AAK91790 (Get FASTA)   NCBI Sequence Viewer  
  CDG86227 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000084327
  ENSMUSP00000084327.3
GenBank Protein Q91WW2 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_705744   ⟸   NM_153524
- UniProtKB: Q1RLL1 (UniProtKB/Swiss-Prot),   Q91WW2 (UniProtKB/Swiss-Prot),   W8W3F5 (UniProtKB/TrEMBL),   B7ZP12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000084327   ⟸   ENSMUST00000087092
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91WW2-F1-model_v2 AlphaFold Q91WW2 1-313 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3033100 AgrOrtholog
Ensembl Genes ENSMUSG00000067173 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000087092 ENTREZGENE
  ENSMUST00000087092.4 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:235854 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:3033100 ENTREZGENE
NCBI Gene 235854 ENTREZGENE
PANTHER PTHR11334 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11334:SF33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mrgpra4 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B7ZP12 ENTREZGENE, UniProtKB/TrEMBL
  MRGA4_MOUSE UniProtKB/Swiss-Prot
  Q1RLL1 ENTREZGENE
  Q91WW2 ENTREZGENE
  W8W3F5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q1RLL1 UniProtKB/Swiss-Prot