Mylk4 (myosin light chain kinase family, member 4) - Rat Genome Database

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Gene: Mylk4 (myosin light chain kinase family, member 4) Mus musculus
Analyze
Symbol: Mylk4
Name: myosin light chain kinase family, member 4
RGD ID: 1618950
MGI Page MGI
Description: Predicted to enable myosin light chain kinase activity. Orthologous to human MYLK4 (myosin light chain kinase family member 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EG238564; myosin light chain kinase family member 4; sgK085; sugen kinase 85
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391332,884,807 - 32,967,947 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1332,884,810 - 32,967,937 (-)EnsemblGRCm39 Ensembl
GRCm381332,700,824 - 32,806,773 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1332,700,827 - 32,783,954 (-)EnsemblGRCm38mm10GRCm38
MGSCv371332,792,696 - 32,873,648 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361332,716,344 - 32,791,693 (-)NCBIMGSCv36mm8
Celera1332,909,607 - 32,990,711 (-)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:16141072   PMID:16141073   PMID:21873635   PMID:27325775   PMID:33870126  


Genomics

Comparative Map Data
Mylk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391332,884,807 - 32,967,947 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1332,884,810 - 32,967,937 (-)EnsemblGRCm39 Ensembl
GRCm381332,700,824 - 32,806,773 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1332,700,827 - 32,783,954 (-)EnsemblGRCm38mm10GRCm38
MGSCv371332,792,696 - 32,873,648 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361332,716,344 - 32,791,693 (-)NCBIMGSCv36mm8
Celera1332,909,607 - 32,990,711 (-)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.72NCBI
MYLK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3862,663,637 - 2,770,376 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl62,663,629 - 2,770,330 (-)EnsemblGRCh38hg38GRCh38
GRCh3762,663,871 - 2,770,610 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3662,608,870 - 2,696,153 (-)NCBINCBI36Build 36hg18NCBI36
Celera63,892,821 - 3,980,110 (-)NCBICelera
Cytogenetic Map6p25.2NCBI
HuRef62,536,304 - 2,624,297 (-)NCBIHuRef
CHM1_162,665,967 - 2,753,728 (-)NCBICHM1_1
T2T-CHM13v2.062,529,217 - 2,636,238 (-)NCBIT2T-CHM13v2.0
Mylk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,877,739 - 31,956,012 (+)NCBIGRCr8
mRatBN7.21731,669,028 - 31,747,250 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1731,661,513 - 31,744,544 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01732,980,753 - 33,056,578 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1732,082,937 - 32,100,166 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1733,028,293 - 33,045,690 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01733,976,723 - 34,004,177 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01734,873,053 - 34,948,155 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1731,231,423 - 31,306,810 (+)NCBICelera
Cytogenetic Map17p12NCBI
Mylk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546510,613,914 - 10,684,629 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546510,590,235 - 10,690,630 (+)NCBIChiLan1.0ChiLan1.0
MYLK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2517,290,291 - 17,392,601 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1613,281,520 - 13,383,250 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v062,486,235 - 2,587,893 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.162,590,139 - 2,686,737 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl62,597,456 - 2,686,770 (-)Ensemblpanpan1.1panPan2
MYLK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1352,997,595 - 3,107,400 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha353,005,815 - 3,115,572 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0353,057,076 - 3,163,236 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,060,336 - 3,138,312 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1352,929,667 - 3,039,085 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0352,951,754 - 3,061,676 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0354,284,818 - 4,394,074 (-)NCBIUU_Cfam_GSD_1.0
Mylk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494622,762,667 - 22,871,807 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366333,759,909 - 3,830,384 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366333,748,867 - 3,832,560 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYLK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.171,567,816 - 1,656,230 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.271,668,984 - 1,745,594 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYLK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11769,398,995 - 69,486,934 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660442,610,927 - 2,696,776 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mylk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475622,076,307 - 22,142,513 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475622,054,285 - 22,149,819 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mylk4
2403 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2129
Count of miRNA genes:783
Interacting mature miRNAs:1021
Transcripts:ENSMUST00000057428, ENSMUST00000132206, ENSMUST00000134352
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301255Cd4ts6_mCD4 T cell subset 6 (mouse)Not determined1316854534168684Mouse
10449140Eosn2_meosinophil differential 2 (mouse)1322131134221311Mouse
15039338Nmrs34_mNAFLD-associated magnetic resonance shift 34 (mouse)1322131134221311Mouse
1301455Bmd3_mbone mineral density 3 (mouse)Not determined13347761237477820Mouse
10045624Heal24_mwound healing/regeneration (mouse)Not determined13347761237477820Mouse
10045625Heal23_mwound healing/regeneration 23 (mouse)Not determined13347761237477820Mouse
1301367Twq1_mtestis weight QTL 1 (mouse)Not determined13361551237615672Mouse
1301733Heal3_mwound healing/regeneration 3 (mouse)Not determined13368020037680343Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse
10402494Igmsc1_mimmunoglobulin M secreting cells 1 (mouse)Not determined131716854544918560Mouse
1301984Pbd2_mpeak bone density 2 (mouse)Not determined131718950838947406Mouse
1301880Hypt_mhypertension (mouse)Not determined131815679252156924Mouse
13463469Gssq1_mglomerulosclerosis severity QTL 1 (mouse)131906090853061050Mouse
12880423V25Dq7_mvitamin D inactive form serum level QTL 7 (mouse)131958398353583983Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132061551255720517Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
10045618Heal17_mwound healing/regeneration 17 (mouse)Not determined132074693954747056Mouse
4142489Ath25_matherosclerosis 25 (mouse)Not determined2583652959836529Mouse
10401111Pgia40_mproteoglycan induced arthritis 40 (mouse)Not determined132791846961918560Mouse
1300710Pcd4ts2_mp-glycoprotein positive CD4 T cell subset 2 (mouse)Not determined132821044262210544Mouse
1357802Vtbt15_mvertebral trabecular bone trait 15 (mouse)Not determined132821737962217515Mouse
10045621Heal21_mwound healing/regeneration 21 (mouse)Not determined132821737962217515Mouse
10755533Chol18_mcholesterol 18 (mouse)133096946764969467Mouse
10755517Chol15_mcholesterol 15 (mouse)133096946764969467Mouse
12738439Twq4_mtestis weight QTL 4 (mouse)133112911065129110Mouse
14696729Kidlq2_mkidney weight, left QTL 2 (mouse)133134473665344736Mouse
14700800Syncq10_msynovial calcification QTL 10 (mouse)133244098333693983Mouse

Markers in Region
D13Mit265  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381332,770,541 - 32,770,650UniSTSGRCm38
MGSCv371332,862,410 - 32,862,519UniSTSGRCm37
Celera1332,979,473 - 32,979,582UniSTS
Cytogenetic Map13A3.2UniSTS
cM Map1313.0UniSTS
Whitehead Genetic136.6UniSTS
Whitehead/MRC_RH13353.17UniSTS
Whitehead_YAC13 UniSTS
RH126207  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381332,741,892 - 32,742,091UniSTSGRCm38
MGSCv371332,833,761 - 32,833,960UniSTSGRCm37
Celera1332,950,824 - 32,951,023UniSTS
Cytogenetic Map13A3.2UniSTS
Whitehead/MRC_RH13351.46UniSTS
D13Cwr2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381332,702,775 - 32,702,918UniSTSGRCm38
MGSCv371332,794,644 - 32,794,787UniSTSGRCm37
Celera1332,911,555 - 32,911,698UniSTS
Cytogenetic Map13A3.2UniSTS
cM Map13 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000057428   ⟹   ENSMUSP00000060149
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1332,884,810 - 32,965,762 (-)Ensembl
GRCm38.p6 Ensembl1332,700,827 - 32,781,779 (-)Ensembl
RefSeq Acc Id: ENSMUST00000132206
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1332,950,497 - 32,967,937 (-)Ensembl
GRCm38.p6 Ensembl1332,766,514 - 32,783,954 (-)Ensembl
RefSeq Acc Id: ENSMUST00000229922
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1332,911,850 - 32,960,532 (-)Ensembl
GRCm38.p6 Ensembl1332,727,867 - 32,776,549 (-)Ensembl
RefSeq Acc Id: ENSMUST00000230119   ⟹   ENSMUSP00000155702
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1332,901,558 - 32,960,396 (-)Ensembl
GRCm38.p6 Ensembl1332,717,575 - 32,776,413 (-)Ensembl
RefSeq Acc Id: ENSMUST00000238977   ⟹   ENSMUSP00000159085
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1332,884,817 - 32,967,937 (-)Ensembl
GRCm38.p6 Ensembl1332,700,834 - 32,783,954 (-)Ensembl
RefSeq Acc Id: NM_001368880   ⟹   NP_001355809
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391332,884,807 - 32,967,947 (-)NCBI
GRCm381332,700,824 - 32,783,964 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001426639   ⟹   NP_001413568
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391332,884,813 - 32,967,947 (-)NCBI
RefSeq Acc Id: XM_006516668   ⟹   XP_006516731
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391332,884,813 - 32,960,558 (-)NCBI
GRCm381332,703,405 - 32,776,641 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001355809 (Get FASTA)   NCBI Sequence Viewer  
  NP_001413568 (Get FASTA)   NCBI Sequence Viewer  
  XP_006516731 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000060149.5
  ENSMUSP00000155702.2
  ENSMUSP00000159085
  ENSMUSP00000159085.3
GenBank Protein Q5SUV5 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_006516731   ⟸   XM_006516668
- Peptide Label: isoform X1
- UniProtKB: A0A5F8MPR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001355809   ⟸   NM_001368880
- Peptide Label: isoform 1
- UniProtKB: A0A5F8MPR5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000155702   ⟸   ENSMUST00000230119
RefSeq Acc Id: ENSMUSP00000159085   ⟸   ENSMUST00000238977
RefSeq Acc Id: ENSMUSP00000060149   ⟸   ENSMUST00000057428
RefSeq Acc Id: NP_001413568   ⟸   NM_001426639
- Peptide Label: isoform 2
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5SUV5-F1-model_v2 AlphaFold Q5SUV5 1-386 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3643758 AgrOrtholog
Ensembl Genes ENSMUSG00000044951 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000057428.13 UniProtKB/TrEMBL
  ENSMUST00000230119.2 UniProtKB/TrEMBL
  ENSMUST00000238977 ENTREZGENE
  ENSMUST00000238977.3 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:3643758 ENTREZGENE
NCBI Gene 238564 ENTREZGENE
PANTHER MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mylk4 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2R8VI35_MOUSE UniProtKB/TrEMBL
  A0A5F8MPR5 ENTREZGENE, UniProtKB/TrEMBL
  F8WIP5_MOUSE UniProtKB/TrEMBL
  MYLK4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE