A4gnt (alpha-1,4-N-acetylglucosaminyltransferase) - Rat Genome Database

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Gene: A4gnt (alpha-1,4-N-acetylglucosaminyltransferase) Mus musculus
Analyze
Symbol: A4gnt
Name: alpha-1,4-N-acetylglucosaminyltransferase
RGD ID: 1618773
MGI Page MGI
Description: Enables acetylglucosaminyltransferase activity. Acts upstream of or within negative regulation of epithelial cell proliferation and protein O-linked glycosylation. Predicted to be located in Golgi apparatus and membrane. Orthologous to human A4GNT (alpha-1,4-N-acetylglucosaminyltransferase).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: alph; Alpha4gnt; AV080780; Gm798
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39999,473,233 - 99,504,420 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl999,494,555 - 99,504,420 (+)EnsemblGRCm39 Ensembl
GRCm38999,591,179 - 99,622,367 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl999,612,502 - 99,622,367 (+)EnsemblGRCm38mm10GRCm38
MGSCv37999,512,921 - 99,522,786 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36999,421,854 - 99,431,719 (+)NCBIMGSCv36mm8
Celera999,148,870 - 99,158,739 (+)NCBICelera
Cytogenetic Map9E3.3NCBI
cM Map951.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Clinical utility of quantitative RT-PCR targeted to alpha1,4-N-acetylglucosaminyltransferase mRNA for detection of pancreatic cancer. Ishizone S, etal., Cancer Sci. 2006 Feb;97(2):119-26.
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10430883   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14681479   PMID:16141072   PMID:16141073   PMID:19751437   PMID:21267068  
PMID:21873635   PMID:22307328   PMID:31246144   PMID:32025032   PMID:34210998  


Genomics

Comparative Map Data
A4gnt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39999,473,233 - 99,504,420 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl999,494,555 - 99,504,420 (+)EnsemblGRCm39 Ensembl
GRCm38999,591,179 - 99,622,367 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl999,612,502 - 99,622,367 (+)EnsemblGRCm38mm10GRCm38
MGSCv37999,512,921 - 99,522,786 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36999,421,854 - 99,431,719 (+)NCBIMGSCv36mm8
Celera999,148,870 - 99,158,739 (+)NCBICelera
Cytogenetic Map9E3.3NCBI
cM Map951.91NCBI
A4GNT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383138,123,713 - 138,133,302 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3138,123,713 - 138,132,390 (-)EnsemblGRCh38hg38GRCh38
GRCh373137,842,555 - 137,851,232 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363139,325,756 - 139,333,897 (-)NCBINCBI36Build 36hg18NCBI36
Celera3136,267,340 - 136,276,009 (-)NCBICelera
Cytogenetic Map3q22.3NCBI
HuRef3135,217,324 - 135,225,993 (-)NCBIHuRef
CHM1_13137,806,379 - 137,815,048 (-)NCBICHM1_1
T2T-CHM13v2.03140,864,300 - 140,873,888 (-)NCBIT2T-CHM13v2.0
A4gnt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88109,050,362 - 109,058,539 (+)NCBIGRCr8
mRatBN7.28100,172,038 - 100,179,218 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8100,172,104 - 100,178,569 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.08107,856,853 - 107,866,438 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8107,859,366 - 107,865,789 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08107,282,862 - 107,290,193 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48104,476,664 - 104,491,166 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera899,569,661 - 99,579,946 (+)NCBICelera
Cytogenetic Map8q31NCBI
A4gnt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955501881,851 - 887,639 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955501881,851 - 887,977 (+)NCBIChiLan1.0ChiLan1.0
A4GNT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22136,028,637 - 136,037,305 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13136,033,366 - 136,042,034 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03135,151,027 - 135,159,692 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13142,602,475 - 142,610,835 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3142,602,475 - 142,610,835 (-)Ensemblpanpan1.1panPan2
A4GNT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12334,339,955 - 34,352,204 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2334,341,628 - 34,348,068 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2334,332,534 - 34,344,786 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02334,879,898 - 34,892,137 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2334,880,571 - 34,888,069 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12334,561,786 - 34,574,038 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02334,627,173 - 34,639,418 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02334,878,243 - 34,890,497 (-)NCBIUU_Cfam_GSD_1.0
A4gnt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560273,739,415 - 73,744,589 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936540479,290 - 484,370 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936540479,290 - 484,370 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
A4GNT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1378,923,681 - 78,932,504 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11378,921,212 - 78,932,575 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21386,522,225 - 86,529,461 (+)NCBISscrofa10.2Sscrofa10.2susScr3
A4GNT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11552,407,272 - 52,417,129 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1552,410,321 - 52,416,867 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604125,422,500 - 25,431,991 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
A4gnt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473014,634,480 - 14,640,070 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473014,634,378 - 14,640,070 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in A4gnt
1110 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:504
Count of miRNA genes:361
Interacting mature miRNAs:408
Transcripts:ENSMUST00000042553
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49452421101406120Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95203447899792481Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959897283109089068Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966089077100089175Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967006220101006220Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968779563102779705Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968779563102779705Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969121898103121973Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969428566103428698Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972859058106859205Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972859058106859205Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974250230108250378Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975682646114303447Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975682646114303447Mouse
1301869Tbbmd4_mtotal body bone mineral density 4 (mouse)Not determined976024387101406120Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976417989110418183Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978522698112522808Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979279863113279941Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981680321115680445Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982792386116792481Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982792386116792481Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982792386116792481Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984406017118406120Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985779563108518385Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986107600120107729Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986121898120118690Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986625682120625682Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987677199121677199Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989162124123162124Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989289476123289595Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989440541123440541Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989859058118767089Mouse
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994863354112701997Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse

Markers in Region
BM383234  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38999,621,106 - 99,621,285UniSTSGRCm38
MGSCv37999,521,525 - 99,521,704UniSTSGRCm37
Celera999,157,478 - 99,157,657UniSTS
Cytogenetic Map9E3.3UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000042553   ⟹   ENSMUSP00000045629
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl999,494,555 - 99,504,420 (+)Ensembl
GRCm38.p6 Ensembl999,612,502 - 99,622,367 (+)Ensembl
RefSeq Acc Id: NM_001077424   ⟹   NP_001070892
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39999,494,555 - 99,504,420 (+)NCBI
GRCm38999,612,502 - 99,622,367 (+)NCBI
MGSCv37999,512,921 - 99,522,786 (+)RGD
Celera999,148,870 - 99,158,739 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006511244   ⟹   XP_006511307
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39999,495,068 - 99,504,153 (+)NCBI
GRCm38999,613,014 - 99,622,100 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006511246   ⟹   XP_006511309
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39999,473,233 - 99,504,153 (+)NCBI
GRCm38999,591,179 - 99,622,100 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001070892   ⟸   NM_001077424
- UniProtKB: Q14BT6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006511309   ⟸   XM_006511246
- Peptide Label: isoform X2
- UniProtKB: Q14BT6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006511307   ⟸   XM_006511244
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000045629   ⟸   ENSMUST00000042553

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q14BT6-F1-model_v2 AlphaFold Q14BT6 1-341 view protein structure

Promoters
RGD ID:8670572
Promoter ID:EPDNEW_M13317
Type:initiation region
Name:A4gnt_1
Description:Mus musculus alpha-1,4-N-acetylglucosaminyltransferase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38999,612,514 - 99,612,574EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2143261 AgrOrtholog
Ensembl Genes ENSMUSG00000037953 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000042553 ENTREZGENE
  ENSMUST00000042553.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.550.20 UniProtKB/Swiss-Prot
InterPro A1-4-GlycosylTfrase_dom UniProtKB/Swiss-Prot
  GlycoTrfase_DXD_sugar-bd_CS UniProtKB/Swiss-Prot
  Nucleotide-diphossugar_trans UniProtKB/Swiss-Prot
KEGG Report mmu:333424 UniProtKB/Swiss-Prot
MGD MGI:2143261 ENTREZGENE
NCBI Gene 333424 ENTREZGENE
PANTHER ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE UniProtKB/Swiss-Prot
  LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE UniProtKB/Swiss-Prot
Pfam Gb3_synth UniProtKB/Swiss-Prot
  Gly_transf_sug UniProtKB/Swiss-Prot
PhenoGen A4gnt PhenoGen
Superfamily-SCOP SSF53448 UniProtKB/Swiss-Prot
UniProt A4GCT_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE