Klhl33 (kelch-like 33) - Rat Genome Database

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Gene: Klhl33 (kelch-like 33) Mus musculus
Analyze
Symbol: Klhl33
Name: kelch-like 33
RGD ID: 1618678
MGI Page MGI
Description: Orthologous to human KLHL33 (kelch like family member 33).
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: EG546611; kelch-like protein 33
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,126,038 - 51,134,940 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,126,039 - 51,134,964 (-)EnsemblGRCm39 Ensembl
GRCm381450,888,581 - 50,897,483 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1450,888,582 - 50,897,507 (-)EnsemblGRCm38mm10GRCm38
MGSCv371451,511,064 - 51,512,930 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361449,813,340 - 49,815,206 (-)NCBIMGSCv36mm8
Celera1447,180,595 - 47,182,461 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
Additional References at PubMed
PMID:38355793  


Genomics

Comparative Map Data
Klhl33
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,126,038 - 51,134,940 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,126,039 - 51,134,964 (-)EnsemblGRCm39 Ensembl
GRCm381450,888,581 - 50,897,483 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1450,888,582 - 50,897,507 (-)EnsemblGRCm38mm10GRCm38
MGSCv371451,511,064 - 51,512,930 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361449,813,340 - 49,815,206 (-)NCBIMGSCv36mm8
Celera1447,180,595 - 47,182,461 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.29NCBI
KLHL33
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,425,852 - 20,436,166 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1420,425,852 - 20,436,166 (-)EnsemblGRCh38hg38GRCh38
GRCh371420,894,011 - 20,904,325 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361419,966,848 - 19,973,895 (-)NCBINCBI36Build 36hg18NCBI36
Celera14758,117 - 764,951 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,018,704 - 1,025,556 (-)NCBIHuRef
CHM1_11420,898,350 - 20,905,181 (-)NCBICHM1_1
T2T-CHM13v2.01414,622,721 - 14,633,066 (-)NCBIT2T-CHM13v2.0
Klhl33
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,579,473 - 26,589,766 (-)NCBIGRCr8
mRatBN7.21524,105,923 - 24,114,445 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,105,930 - 24,114,438 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01527,811,226 - 27,819,808 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,813,393 - 27,815,261 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,643,651 - 31,652,183 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41526,866,635 - 26,873,521 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1524,426,061 - 24,434,643 (-)NCBICelera
Cytogenetic Map15p14NCBI
Klhl33
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555501,240,038 - 1,246,438 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555501,239,143 - 1,247,570 (-)NCBIChiLan1.0ChiLan1.0
KLHL33
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21521,935,142 - 21,945,395 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11421,151,629 - 21,161,848 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,300,170 - 1,310,407 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11419,355,040 - 19,362,410 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,355,040 - 19,362,410 (-)Ensemblpanpan1.1panPan2
KLHL33
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11517,761,382 - 17,764,295 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1518,245,742 - 18,254,545 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01518,019,796 - 18,028,620 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11517,702,754 - 17,713,453 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01517,757,367 - 17,766,156 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01517,886,503 - 17,895,307 (-)NCBIUU_Cfam_GSD_1.0
Klhl33
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864077,649,713 - 77,670,866 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936877629,912 - 638,933 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936877630,870 - 638,957 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL33
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl778,470,321 - 78,479,959 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1778,470,250 - 78,479,963 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2783,498,590 - 83,508,302 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL33
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12920,942,839 - 20,954,113 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2920,943,234 - 20,945,059 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605925,470,448 - 25,478,906 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl33
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248254,741,121 - 4,742,944 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248254,735,443 - 4,744,052 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Klhl33
223 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:66
Interacting mature miRNAs:79
Transcripts:ENSMUST00000164415
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
27226744Metcl6_mmetatarsal-calcaneal length 6, 5 week (mouse)143032195752937457Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143322195759437449Mouse
27226727Tibl21_mtibia length 21, 16 week (mouse)143412195752937457Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
4141484Hcbip1_mhexachlorobenzene induced porphyria 1 (mouse)Not determined4733525059962593Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000164415   ⟹   ENSMUSP00000129810
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1451,128,846 - 51,130,712 (-)Ensembl
GRCm38.p6 Ensembl1450,891,389 - 50,893,255 (-)Ensembl
RefSeq Acc Id: ENSMUST00000170855   ⟹   ENSMUSP00000131456
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1451,133,399 - 51,134,913 (-)Ensembl
GRCm38.p6 Ensembl1450,895,942 - 50,897,456 (-)Ensembl
RefSeq Acc Id: ENSMUST00000226765
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1451,133,118 - 51,134,936 (-)Ensembl
GRCm38.p6 Ensembl1450,895,661 - 50,897,479 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227271   ⟹   ENSMUSP00000154785
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1451,126,039 - 51,134,964 (-)Ensembl
GRCm38.p6 Ensembl1450,888,582 - 50,897,507 (-)Ensembl
RefSeq Acc Id: NM_001166651   ⟹   NP_001160123
RefSeq Status: INFERRED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391451,126,038 - 51,132,809 (-)NCBI
GRCm381450,888,581 - 50,895,352 (-)NCBI
MGSCv371451,511,064 - 51,512,930 (-)RGD
Celera1447,180,595 - 47,182,461 (-)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001370764   ⟹   NP_001357693
RefSeq Status: INFERRED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391451,126,038 - 51,134,940 (-)NCBI
GRCm381450,888,581 - 50,897,483 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001160123 (Get FASTA)   NCBI Sequence Viewer  
  NP_001357693 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL20832 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000129810
  ENSMUSP00000129810.2
  ENSMUSP00000131456.2
  ENSMUSP00000154785
  ENSMUSP00000154785.2
Reference Protein Sequences
RefSeq Acc Id: NP_001160123   ⟸   NM_001166651
- Peptide Label: isoform 2
- UniProtKB: G3UW92 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001357693   ⟸   NM_001370764
- Peptide Label: isoform 1
- UniProtKB: A0A2I3BRZ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000129810   ⟸   ENSMUST00000164415
RefSeq Acc Id: ENSMUSP00000131456   ⟸   ENSMUST00000170855
RefSeq Acc Id: ENSMUSP00000154785   ⟸   ENSMUST00000227271
Protein Domains
BACK   BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A2I3BRZ3-F1-model_v2 AlphaFold A0A2I3BRZ3 1-793 view protein structure

Promoters
RGD ID:6824621
Promoter ID:MM_KWN:16567
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   BoneMarrow_0Hour,   Brain,   Lung
Transcripts:AK034241_A930018M24RIK,   NM_001166651
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361451,512,716 - 51,513,216 (-)MPROMDB
RGD ID:6849027
Promoter ID:MM_XEF:2215
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   Brain,   Lung
Transcripts:NM_001109997,   NM_001166652
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361451,516,136 - 51,517,327 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3644593 AgrOrtholog
Ensembl Genes ENSMUSG00000090799 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000164415 ENTREZGENE
  ENSMUST00000164415.2 UniProtKB/TrEMBL
  ENSMUST00000170855.2 UniProtKB/TrEMBL
  ENSMUST00000227271 ENTREZGENE
  ENSMUST00000227271.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  BTB-kelch_protein UniProtKB/TrEMBL
  BTB/POZ_dom UniProtKB/TrEMBL
  BTB/POZ_fold UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
  KLHL33 UniProtKB/TrEMBL
KEGG Report mmu:546611 UniProtKB/TrEMBL
MGD MGI:3644593 ENTREZGENE
NCBI Gene 546611 ENTREZGENE
PANTHER LD33804P UniProtKB/TrEMBL
  PTHR45632:SF14 UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
  KLHL33-like_BTB_POZ UniProtKB/TrEMBL
PhenoGen Klhl33 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
  SSF117281 UniProtKB/TrEMBL
UniProt A0A2I3BRZ3 ENTREZGENE, UniProtKB/TrEMBL
  B7ZMY3_MOUSE UniProtKB/TrEMBL
  G3UW92 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-22 Klhl33  kelch-like 33    kelch-like 33 (Drosophila)  Symbol and/or name change 5135510 APPROVED