Scx (scleraxis scleraxis bHLH transcription factor)

Gene: Scx (scleraxis scleraxis bHLH transcription factor) Mus musculus

Analyze

Symbol:

Scx

Name:

scleraxis scleraxis bHLH transcription factor

RGD ID:

1618406

MGI Page

MGI

Description:

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and bHLH transcription factor binding activity. Involved in several processes, including BMP signaling pathway; regulation of gene expression; and skeletal system development. Acts upstream of or within skeletal muscle cell differentiation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut; limb; and sensory organ. Orthologous to human SCX (scleraxis bHLH transcription factor).

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

basic helix-loop-helix transcription factor scleraxis; BB114693; bHLHa; bHLHa41; S; Scl; scleraxis

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SCX (scleraxis bHLH transcription factor)	HGNC	Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, Panther, PhylomeDB
Rattus norvegicus (Norway rat):	Scx (scleraxis bHLH transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Scx (scleraxis bHLH transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SCX (scleraxis bHLH transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SCX (scleraxis bHLH transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Scx (scleraxis bHLH transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SCX (scleraxis bHLH transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SCX (scleraxis bHLH transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Scx (scleraxis bHLH transcription factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Scx (scleraxis bHLH transcription factor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SCX (scleraxis bHLH transcription factor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	scxa (scleraxis bHLH transcription factor a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Danio rerio (zebrafish):	scxb (scleraxis bHLH transcription factor b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Drosophila melanogaster (fruit fly):	CG33557	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	scx	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	76,341,594 - 76,343,668 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	76,341,652 - 76,343,658 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	76,457,411 - 76,459,468 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	76,457,452 - 76,459,458 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	76,287,868 - 76,289,898 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	76,284,693 - 76,286,716 (+)	NCBI		MGSCv36	mm8
Celera	15	77,957,869 - 77,959,899 (+)	NCBI		Celera
Cytogenetic Map	15	D3	NCBI
cM Map	15	35.92	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brown-Vialetto-Van Laere syndrome 2 (ISO)

epidermolysis bullosa simplex with muscular dystrophy (ISO)

genetic disease (ISO)

holoprosencephaly (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (EXP)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (EXP)

2,2',5,5'-tetrachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3,3',5,5'-tetrabromobisphenol A (EXP)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (EXP)

6-propyl-2-thiouracil (ISO)

amitrole (ISO)

aristolochic acid A (ISO)

atrazine (ISO)

benzo[a]pyrene (EXP)

benzo[b]fluoranthene (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

carbon nanotube (EXP)

chloroprene (EXP)

choline (EXP)

copper atom (ISO)

copper(0) (ISO)

decabromodiphenyl ether (ISO)

dibutyl phthalate (ISO)

diethylstilbestrol (EXP)

ethanol (EXP)

fenvalerate (ISO)

fluoranthene (EXP)

folic acid (EXP)

furan (ISO)

gentamycin (ISO)

L-methionine (EXP)

mancozeb (ISO)

methimazole (ISO)

ozone (EXP)

paracetamol (ISO)

PCB138 (EXP)

pinostrobin (ISO)

progesterone (EXP)

resveratrol (ISO)

tetrachloroethene (EXP)

Theaflavin 3,3'-digallate (ISO)

trichloroethene (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

BMP signaling pathway (IMP)

cartilage development (NAS)

cell differentiation (IMP)

cellular response to BMP stimulus (IEP)

cellular response to mechanical stimulus (IEP)

cellular response to transforming growth factor beta stimulus (IEP)

chondrocyte differentiation (IMP)

collagen fibril organization (IMP)

deltoid tuberosity development (IMP)

developmental process (IBA)

DNA-templated transcription (IDA)

embryonic skeletal system development (IEP)

endochondral ossification (IMP)

face morphogenesis (IEP)

heart valve formation (IMP)

heart valve morphogenesis (IMP)

mesoderm formation (IMP)

negative regulation of apoptotic process (IMP)

negative regulation of DNA-templated transcription (IMP)

positive regulation of cartilage development (IMP)

positive regulation of cell population proliferation (IMP)

positive regulation of collagen biosynthetic process (IDA,IMP)

positive regulation of DNA-templated transcription (IDA)

positive regulation of gastrulation (IMP)

positive regulation of gene expression (IDA,IMP)

positive regulation of transcription by RNA polymerase II (IDA,IGI,ISO)

regulation of cartilage development (IMP)

regulation of transcription by RNA polymerase II (IBA)

sclerotome development (IEP)

skeletal muscle cell differentiation (IMP)

tendon cell differentiation (IMP)

tendon development (IMP)

tendon formation (IMP)

tissue homeostasis (IMP)

Cellular Component

nucleus (IDA,ISO)

transcription regulator complex (IDA,ISO)

Molecular Function

bHLH transcription factor binding (IPI,ISO)

cis-regulatory region sequence-specific DNA binding (IDA)

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IDA,ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

E-box binding (IDA,ISO)

protein binding (IPI)

protein dimerization activity (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IDA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IBA)

sequence-specific DNA binding (IDA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal ectoplacental cone morphology (IAGP)

abnormal egg cylinder morphology (IAGP)

abnormal extraembryonic tissue morphology (IAGP)

abnormal parietal endoderm morphology (IAGP)

abnormal sclerotome morphology (IAGP)

abnormal tail morphology (IAGP)

abnormal tail movements (IAGP)

abnormal tendon morphology (IAGP)

abnormal tendon stiffness (IAGP)

abnormal visceral endoderm morphology (IAGP)

absent deltoid tuberosity (IAGP)

absent mesoderm (IAGP)

absent somites (IAGP)

dilated dorsal aorta (IAGP)

embryonic growth arrest (IAGP)

embryonic growth retardation (IAGP)

embryonic lethality between somite formation and embryo turning, incomplete penetrance (IAGP)

failure of primitive streak formation (IAGP)

failure to gastrulate (IAGP)

impaired righting response (IAGP)

microcephaly (IEA)

no abnormal phenotype detected (IAGP)

preweaning lethality, complete penetrance (IEA)

syndactyly (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7729571	PMID:7743923	PMID:8889548	PMID:8918877	PMID:8955271	PMID:9027489	PMID:9050988	PMID:9106663	PMID:9328840	PMID:9520323	PMID:9799236	PMID:10208749
PMID:10349636	PMID:10477299	PMID:10804168	PMID:10804169	PMID:11042159	PMID:11076861	PMID:11217851	PMID:11585810	PMID:12168674	PMID:12441295	PMID:12466851	PMID:12477932
PMID:12705871	PMID:12837285	PMID:14568104	PMID:15183306	PMID:15261831	PMID:15371327	PMID:15604102	PMID:15618518	PMID:15634692	PMID:15728667	PMID:15788460	PMID:15804569
PMID:16141072	PMID:16141073	PMID:16169709	PMID:16408284	PMID:16971476	PMID:17138667	PMID:17430895	PMID:17477400	PMID:17497702	PMID:17567668	PMID:17693064	PMID:18239943
PMID:18287559	PMID:18361414	PMID:18498113	PMID:18539921	PMID:18557763	PMID:18684439	PMID:18802027	PMID:18816853	PMID:19176584	PMID:19198652	PMID:19304887	PMID:19362560
PMID:19384958	PMID:19463829	PMID:19590010	PMID:19698141	PMID:19828133	PMID:19996321	PMID:20059953	PMID:20059955	PMID:20193675	PMID:20206616	PMID:20498044	PMID:20696843
PMID:20740671	PMID:21038449	PMID:21173153	PMID:21254332	PMID:21267068	PMID:21399989	PMID:21455939	PMID:21600772	PMID:21625049	PMID:21873635	PMID:21913219	PMID:21939397
PMID:22147266	PMID:22190307	PMID:22228095	PMID:22377357	PMID:22421048	PMID:22438570	PMID:22474292	PMID:22837482	PMID:23034633	PMID:23349075	PMID:23499659	PMID:23555841
PMID:23615282	PMID:23650387	PMID:23653374	PMID:23720048	PMID:24044893	PMID:24058692	PMID:24146773	PMID:24154528	PMID:24157418	PMID:24194600	PMID:24385915	PMID:24912677
PMID:24983472	PMID:25249460	PMID:25535917	PMID:25715398	PMID:25926361	PMID:26062940	PMID:26395480	PMID:26443819	PMID:26701347	PMID:26883788	PMID:26969076	PMID:26988708
PMID:27019229	PMID:27324126	PMID:27527664	PMID:27862618	PMID:27864378	PMID:28166224	PMID:28172500	PMID:28327634	PMID:28332620	PMID:28438836	PMID:28937836	PMID:29084951
PMID:29231808	PMID:29453333	PMID:29507095	PMID:29618652	PMID:29750994	PMID:29768404	PMID:30002128	PMID:30021842	PMID:30225906	PMID:30458056	PMID:30738849	PMID:30745426
PMID:30854720	PMID:31320326	PMID:31540914	PMID:31719045	PMID:31874220	PMID:32132649	PMID:32439983	PMID:32463804	PMID:32580935	PMID:32877217	PMID:33059101	PMID:33201874
PMID:33248111	PMID:33259516	PMID:33347679	PMID:33480357	PMID:33482080	PMID:33667029	PMID:33966129	PMID:34091985	PMID:34150754	PMID:34376651	PMID:34557486	PMID:34590686
PMID:34671097	PMID:35648809	PMID:35784484	PMID:36910145	PMID:37047606	PMID:37244931	PMID:37246520	PMID:37261735	PMID:37702066

Genomics

Comparative Map Data

Scx
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	76,341,594 - 76,343,668 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	76,341,652 - 76,343,658 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	76,457,411 - 76,459,468 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	76,457,452 - 76,459,458 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	76,287,868 - 76,289,898 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	76,284,693 - 76,286,716 (+)	NCBI		MGSCv36	mm8
Celera	15	77,957,869 - 77,959,899 (+)	NCBI		Celera
Cytogenetic Map	15	D3	NCBI
cM Map	15	35.92	NCBI

SCX
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	144,266,453 - 144,268,481 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	144,266,453 - 144,268,481 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	145,321,356 - 145,323,384 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	145,393,505 - 145,395,033 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	8	141,665,524 - 141,666,939 (+)	NCBI		Celera
Cytogenetic Map	8	q24.3	NCBI
HuRef	8	140,605,530 - 140,607,095 (+)	NCBI		HuRef
CHM1_1	8	145,595,226 - 145,596,688 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	145,433,863 - 145,437,284 (+)	NCBI		T2T-CHM13v2.0

Scx
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	110,056,897 - 110,059,283 (+)	NCBI		GRCr8
mRatBN7.2	7	108,176,608 - 108,178,626 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	108,176,608 - 108,178,626 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	109,921,000 - 109,923,018 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	112,144,697 - 112,146,715 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	112,103,048 - 112,105,066 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	117,519,075 - 117,521,093 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	117,519,075 - 117,521,093 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	117,506,706 - 117,508,724 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	114,504,701 - 114,506,719 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	104,528,235 - 104,530,253 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

Scx
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955454	2,886,981 - 2,888,829 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955454	2,886,981 - 2,888,829 (+)	NCBI	ChiLan1.0	ChiLan1.0

SCX
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	161,751,296 - 161,754,726 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	137,281,132 - 137,284,629 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	141,027,765 - 141,031,194 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	144,018,463 - 144,021,487 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

SCX
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	37,701,781 - 37,704,949 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	37,703,232 - 37,704,657 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	37,665,396 - 37,668,564 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	38,178,072 - 38,181,239 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	13	37,850,219 - 37,853,385 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	37,978,828 - 37,981,997 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	38,455,164 - 38,458,331 (+)	NCBI		UU_Cfam_GSD_1.0

Scx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936470	7,966,096 - 7,972,379 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SCX
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	500,526 - 503,193 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	500,884 - 503,276 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

SCX
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	138,476,902 - 138,482,185 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	138,478,458 - 138,480,459 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	1,384,906 - 1,388,296 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Scx
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624735	12,579,956 - 12,581,736 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624735	12,579,963 - 12,583,128 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Scx
40 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	138
Count of miRNA genes:	127
Interacting mature miRNAs:	132
Transcripts:	ENSMUST00000043089
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4141952	W3q7_m	weight 3 weeks QTL 7 (mouse)			Not determined			3489694	78601286	Mouse
4142252	Tailaq4_m	tail length adjusted QTL 4 (mouse)			Not determined			3489694	78601286	Mouse
4142448	Tailq6_m	tail length QTL 6 (mouse)			Not determined			3489694	78601286	Mouse
1357559	Scfq2_m	subcutaneous fat pad weight QTL 2 (mouse)			Not determined		15	3489694	78601286	Mouse
1357659	Epfpq4_m	epididymal fat percentage QTL 4 (mouse)			Not determined		15	3489694	78601286	Mouse
27095932	Ulnl11_m	ulna length 11, 16 week (mouse)					15	6129481	76384200	Mouse
27226717	Tibw4_m	tibia width 4, proximal, 10 week (mouse)					15	6129481	78684200	Mouse
27226734	Tibmd5_m	tibia midshaft diameter 5, 10 week (mouse)					15	6129481	86684201	Mouse
26884442	Sklq6_m	skull length QTL 6, 5 week (mouse)					15	6129481	100797881	Mouse
27226777	Tibl8_m	tibia length 8, 5 week (mouse)					15	6929481	84584201	Mouse
1301433	Rapop5_m	radiation-induced apoptosis 5 (mouse)			Not determined		15	9273022	79474762	Mouse
1357526	Hyplip2_m	hyperlipidemia 2 (mouse)			Not determined		15	12402203	102896555	Mouse
26884425	Cvht2_m	cranial vault height 2, 5 week (mouse)					15	28800146	102008435	Mouse
1558985	Eae32_m	experimental allergic encephalomyelitis susceptibility 32 (mouse)			Not determined		15	32578416	103425899	Mouse
27226729	Tibmd2_m	tibia midshaft diameter 2, 5 week (mouse)					15	38000244	86684201	Mouse
26884402	Cvht9_m	cranial vault height 9, 16 week (mouse)					15	42163396	95497881	Mouse
1357703	Vtbt17_m	vertebral trabecular bone trait 17 (mouse)			Not determined		15	44553313	78553437	Mouse
1301568	Tria2_m	T-cell receptor induced activation 2 (mouse)			Not determined		15	44859141	78859281	Mouse
1357756	Alaa4_m	alopecia areata 4 (mouse)			Not determined		15	46389646	80389845	Mouse
10755515	Amzn3_m	anatomical modifier of Zfp423 3 (mouse)					15	46389646	80389845	Mouse
1301006	Hfib1_m	hepatic fibrogenesis 1 (mouse)			Not determined		15	47306334	81306479	Mouse
1301860	Gct3_m	granulosa cell tumorigenesis 3 (mouse)			Not determined		15	47409596	81409691	Mouse
26884397	Humsd5_m	humerus midshaft diameter 5, 10 week (mouse)					15	48363396	98397881	Mouse
26884399	Humsd1_m	humerus midshaft diameter 1, 5 week (mouse)					15	48363396	101708435	Mouse
1301429	Pcir3_m	periosteal circumference 3 (mouse)			Not determined		15	48465362	82465496	Mouse
1301779	Dpml_m	dopamine loss (mouse)			Not determined		15	51004694	76794493	Mouse
4142198	Hbtq_m	habituation QTL (mouse)			Not determined		15	51160708	85160833	Mouse
10045637	Heal27_m	wound healing/regeneration 29 (mouse)			Not determined		15	51418361	85418511	Mouse
10412067	Pain2_m	pain 2 (mouse)			Not determined		15	51645339	85645626	Mouse
1302080	Szs13_m	seizure susceptibility 13 (mouse)			Not determined		15	51685832	85694449	Mouse
1301708	Cocrb14_m	cocaine related behavior 14 (mouse)			Not determined		15	51806515	85806651	Mouse
38501067	Tip3_m	tuberculosis immunophenotype 3, IFN-g level (mouse)					15	53563396	89584203	Mouse
13504731	Cath5_m	carotid atherosclerosis 5 (mouse)					15	54789129	88789129	Mouse
1302074	Bmd4_m	bone mineral density 4 (mouse)			Not determined		15	56186708	103425899	Mouse
27095936	Ulnl4_m	ulna length 4, 5 week (mouse)					15	56763396	87684201	Mouse
1300800	Ses3_m	salmonella enteritidis susceptibility 3 (mouse)			Not determined		15	57117005	91117153	Mouse
1357407	Pfat4_m	predicted fat percentage 4 (mouse)	8.6		Body fat amount	predicted fat percentage	15	57117005	91117153	Mouse
12880420	V25Dq8_m	vitamin D inactive form serum level QTL 8 (mouse)					15	61584200	95584200	Mouse
1301601	Faq9_m	fluctuating asymmetry QTL 9 (mouse)			Not determined		15	63163903	97163995	Mouse
1558786	Msq1_m	MAV-1 susceptibility QTL 1 (mouse)			Not determined		15	63389646	81086436	Mouse
1302197	Bhr2_m	bronchial hyperresponsiveness 2 (mouse)			Not determined		15	64306334	103425899	Mouse
4141135	Cia35_m	collagen induced arthritis 35 (mouse)			Not determined		15	64811826	98811946	Mouse
1301119	Drb7_m	dopamine receptor binding 7 (mouse)			Not determined		15	65336578	99341028	Mouse
1301171	Brm2_m	brachyury modifier 2 (mouse)			Not determined		15	65525376	99525499	Mouse
4141921	Pstc3_m	periosteal circumference 3 (mouse)			Not determined		15	67270698	101270847	Mouse
1300627	Sluc26_m	susceptibility to lung cancer 26 (mouse)			Not determined		15	70345653	104073951	Mouse
1300648	Dbsty4_m	diabesity 4 (mouse)			Not determined		15	70349271	104073951	Mouse
1300726	Pitm4_m	prion incubation time 4 (mouse)			Not determined		15	70349271	104073951	Mouse
1300844	Emo2_m	emotionality 2 (mouse)			Not determined		15	72372459	76794493	Mouse
1302002	Cocia2_m	cocaine induced activation 2 (mouse)			Not determined		15	72372459	79899178	Mouse
14747011	Mancz13_m	mandible centroid size 13 (mouse)					15	72382669	104073951	Mouse
12791003	Aath8_m	aortic arch atherosclerosis 8 (mouse)					15	73430144	104073951	Mouse
15092079	Igly6_m	IgG glycosylation 6, GP6 (mouse)					15	74100540	82674156	Mouse
13442492	Mecth2_m	mechanosensation threshold 2 (mouse)					15	74662849	79387201	Mouse
1301472	Pain1_m	pain 1 (mouse)			Not determined		15	75320846	90813185	Mouse

Markers in Region

Scx

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
MGSCv37	15	76,288,588 - 76,289,638	UniSTS	GRCm37
Celera	15	77,958,589 - 77,959,639	UniSTS
Cytogenetic Map	15	D3	UniSTS
cM Map	15	43.3	UniSTS
cM Map	15	43.0	UniSTS
cM Map	15	43.3	UniSTS

Scx

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	15	76,458,158 - 76,459,208	UniSTS	GRCm38
MGSCv37	15	76,288,588 - 76,289,638	UniSTS	GRCm37
Celera	15	77,958,589 - 77,959,639	UniSTS
Cytogenetic Map	15	D3	UniSTS
cM Map	15	43.3	UniSTS

Scx

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	15	D3	UniSTS
cM Map	15	43.3	UniSTS

Scx

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	15	D3	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_198885	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006520660	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB221642	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC157566	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK013456	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AV162294	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY338482	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC062161	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466545	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S78079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000043089 ⟹ ENSMUSP00000043668

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	15	76,341,720 - 76,343,649 (+)	Ensembl
GRCm38.p6 Ensembl	15	76,457,520 - 76,459,449 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000229271

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	15	76,341,652 - 76,343,658 (+)	Ensembl
GRCm38.p6 Ensembl	15	76,457,452 - 76,459,458 (+)	Ensembl

RefSeq Acc Id:

NM_198885 ⟹ NP_942588

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	15	76,341,638 - 76,343,668 (+)	NCBI
GRCm38	15	76,457,438 - 76,459,468 (+)	NCBI
MGSCv37	15	76,287,868 - 76,289,898 (+)	RGD
Celera	15	77,957,869 - 77,959,899 (+)	RGD
cM Map	15		ENTREZGENE

Sequence:

show sequence

CTCGGCTGGCGGCCCCACTCCAGTCCGAACACATGTGCCCGCCTCACCCGGCAGCCGCCACCGC
GGGGCGCAGCGGAGACCCCTGGCCCGGCGGCCTGTGGGGACCTAAAGAGGCGGCATGAGCAGCG
CACGGTGGAGCTGACGCCGCGCCCCCTGCCCGGCCCATGTCCTTCGCCATGCTGCGTTCAGCGC
CGCCGCCGGGTCGCTACCTGTACCCTGAGGTGAGCCCGCTGTCGGAGGATGAGGACCGCGGAAG
CGAGAGCTCGGGCTCCGACGAGAAACCCTGCCGTGTGCATGCTGCGCGCTGTGGCCTCCAGGGC
GCCCGGCGGCGGGCAGGAGGACGGAGGGCCGCGGGTAGCGGGCCAGGACCCGGGGGGCGGCCAG
GCCGCGAGCCCCGGCAGCGGCACACAGCGAATGCGCGCGAGCGGGACCGCACCAACAGCGTGAA
CACGGCCTTCACTGCGCTGCGCACACTCATCCCCACCGAGCCAGCGGACCGCAAGCTCTCCAAG
ATTGAGACGCTGCGCCTGGCCTCCAGCTACATTTCTCACCTGGGCAATGTGCTGCTGGTGGGTG
AGGCCTGTGGCGACGGGCAACCATGCCACTCGGGACCCGCTTTCTTCCACAGCGGTCGTGCGGG
CAGCCCACTGCCACCGCCGCCGCCGCCACCACCACTGGCCAGAGACGGCGGCGAGAACACCCAG
CCCAAACAGATCTGCACCTTCTGCCTCAGCAACCAGAGAAAGTTGAGCAAAGACCGTGACAGAA
AGACGGCGATTCGAAGTTAGAAGGAGGAGGGTCCACAGCAGCCAAGAGGTGATGCCACTAGTGA
AGGTGGATGCCACTGAAGAGTCACGGAGAGCCCCACTTTGGACCTGATCTGAGCGCAGGTCCCC
AAGAGCACGCTCACCAGGCCAGACCTGCCCCAGCTATGAGCAGGGCCTATGAACAGAGAGATGG
ACAGGCGGGTGATGGCTTGACTCTAAGCAGCCGAACACTGACCCAGGCCCACTGGGACTTTCCA
TGCTGGCTCTCTACCTGGGCCAAGTGTTGGCATCTTGTGTCTTTAATATGATAATATAAAGTCT
GGAAATTTTGTATAATTAAAAATGAAACAGTATCTTCCAAATTGAGGC

hide sequence

RefSeq Acc Id:

XM_006520660 ⟹ XP_006520723

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	15	76,341,594 - 76,343,263 (+)	NCBI
GRCm38	15	76,457,411 - 76,459,064 (+)	NCBI

Sequence:

show sequence

GGAGGCCAGGCGCGGGGGAGGAGCTGACTGCTATAAAGGCACTGCTCGGCTGGCGGCCCCACTC
CAGTCCGAACACATGTGCCCGCCTCACCCGGCAGCCGCCACCGCGGGGCGCAGCGGAGACCCCT
GGCCCGGCGGCCTGTGGGGACCTAAAGAGGCGGCATGAGCAGCGCACGGTGGAGCTGACGCCGC
GCCCCCTGCCCGGCCCATGTCCTTCGCCATGCTGCGTTCAGCGCCGCCGCCGGGTCGCTACCTG
TACCCTGAGGTGAGCCCGCTGTCGGAGGATGAGGACCGCGGAAGCGAGAGCTCGGGCTCCGACG
AGAAACCCTGCCGTGTGCATGCTGCGCGCTGTGGCCTCCAGGGCGCCCGGCGGCGGGCAGGAGG
ACGGAGGGCCGCGGGTAGCGGGCCAGGACCCGGGGGGCGGCCAGGCCGCGAGCCCCGGCAGCGG
CACACAGCGAATGCGCGCGAGCGGGACCGCACCAACAGCGTGAACACGGCCTTCACTGCGCTGC
GCACACTCATCCCCACCGAGCCAGCGGACCGCAAGCTCTCCAAGATTGAGACGCTGCGCCTGGC
CTCCAGCTACATTTCTCACCTGGGCAATGTGCTGCTGGTGGGTGAGGCCTGTGGCGACGGGCAA
CCATGCCACTCGGGACCCGCTTTCTTCCACAGCGGTCGTGCGGGCAGCCCACTGCCACCGCCGC
CGCCGCCACCACCACTGGCCAGAGACGGCGGCGAGAACACCCAGCCCAAACAGATCTGCACCTT
CTGCCTCAGCAACCAGAGAAAGTTGCCCACCTCCACCCCAAGGCTTATGGGCACCTGCTGCCTC
TCCCCTGGTCTACTGAGACCTGCAGTAGAGGGGCTAGGGGAGAAGGCTGAACTGAGAGATGCTG
GCCAGCCATGATTTACTGCTCTGGCCGCACTTGGTGGCACCGGAAAAGCAGGGTGAGCAGGGAA
AAAATACAACGGCTTTCCCCAATCCCCATTTCCTCTCCAGACAGCACGCGCAAGCTCCTGGGGC
CTGAACATCTGGGAAATTTAATTTTACAGTTTCGGCTCTGCAGCAGTATACTCCCCTCCCCAAA
ATGCACTGTGGGGGTGGCAGGAGCCCGGGATGGGGTGCCCTAGCACAGGCAGTGCCCCCAACAG
GAAGCCAGGAAGGTTCGGGCAGTGCTGGGTGACACTAAGTCTCCACTCAGACCCTGACACA

hide sequence

Protein Sequences


Protein RefSeqs	NP_942588	(Get FASTA)	NCBI Sequence Viewer
	XP_006520723	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB34266	(Get FASTA)	NCBI Sequence Viewer
	AAH62161	(Get FASTA)	NCBI Sequence Viewer
	AAR01197	(Get FASTA)	NCBI Sequence Viewer
	EDL29568	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000043668
	ENSMUSP00000043668.8
GenBank Protein	Q64124	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_942588 ⟸ NM_198885

- UniProtKB:

Q64124 (UniProtKB/Swiss-Prot), Q53ZC3 (UniProtKB/TrEMBL), Q6P6L3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSFAMLRSAPPPGRYLYPEVSPLSEDEDRGSESSGSDEKPCRVHAARCGLQGARRRAGGRRAAG
SGPGPGGRPGREPRQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIETLRLASSYIS
HLGNVLLVGEACGDGQPCHSGPAFFHSGRAGSPLPPPPPPPPLARDGGENTQPKQICTFCLSNQ
RKLSKDRDRKTAIRS

hide sequence

RefSeq Acc Id:	XP_006520723 ⟸ XM_006520660
- Peptide Label:	isoform X1
- UniProtKB:	Q6P6L3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSFAMLRSAPPPGRYLYPEVSPLSEDEDRGSESSGSDEKPCRVHAARCGLQGARRRAGGRRAAG SGPGPGGRPGREPRQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIETLRLASSYIS HLGNVLLVGEACGDGQPCHSGPAFFHSGRAGSPLPPPPPPPPLARDGGENTQPKQICTFCLSNQ RKLPTSTPRLMGTCCLSPGLLRPAVEGLGEKAELRDAGQP hide sequence

RefSeq Acc Id:

ENSMUSP00000043668 ⟸ ENSMUST00000043089

Protein Domains

bHLH

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q64124-F1-model_v2	AlphaFold	Q64124	1-207	view protein structure

Promoters

RGD ID:

6826457

Promoter ID:

MM_KWN:18874

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, Kidney, Lung, MEF_B4, MEF_B6

Transcripts:

NM_198885

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	15	76,286,956 - 76,288,377 (+)	MPROMDB

RGD ID:

8684118

Promoter ID:

EPDNEW_M20089

Type:

single initiation site

Name:

Scx_1

Description:

Mus musculus scleraxis , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	15	76,457,454 - 76,457,514	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:102934	AgrOrtholog
Ensembl Genes	ENSMUSG00000034161	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000043089	ENTREZGENE
	ENSMUST00000043089.9	UniProtKB/Swiss-Prot
Gene3D-CATH	4.10.280.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	bHLH_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HLH_DNA-bd_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:20289	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:102934	ENTREZGENE
NCBI Gene	20289	ENTREZGENE
PANTHER	BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR SCLERAXIS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	HLH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Scx	PhenoGen
PROSITE	BHLH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	HLH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF47459	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	Q53ZC3	ENTREZGENE, UniProtKB/TrEMBL
	Q64124	ENTREZGENE
	Q6P6L3	ENTREZGENE, UniProtKB/TrEMBL
	SCX_MOUSE	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-03-21	Scx	scleraxis scleraxis bHLH transcription factor	Scx	scleraxis	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype