Npffr1 (neuropeptide FF receptor 1) - Rat Genome Database

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Gene: Npffr1 (neuropeptide FF receptor 1) Mus musculus
Analyze
Symbol: Npffr1
Name: neuropeptide FF receptor 1
RGD ID: 1618135
MGI Page MGI
Description: Predicted to enable G protein-coupled receptor activity and peptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cellular response to hormone stimulus. Is active in cilium. Orthologous to human NPFFR1 (neuropeptide FF receptor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor 147; G-protein coupled receptor NPFF1R; Gm236; Gpr1; Gpr147; NPF; NPFF1; NPFF1R; OT7T022; RFamide-related peptide receptor
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391061,430,600 - 61,465,243 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1061,431,271 - 61,464,344 (+)EnsemblGRCm39 Ensembl
GRCm381061,595,295 - 61,629,464 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1061,595,492 - 61,628,565 (+)EnsemblGRCm38mm10GRCm38
MGSCv371061,058,232 - 61,089,133 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361060,991,514 - 61,021,742 (+)NCBIMGSCv36mm8
Celera1062,696,844 - 62,727,819 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cilium  (IDA,ISO)
plasma membrane  (IBA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12679517   PMID:14696013   PMID:15121216   PMID:16141072   PMID:16141073   PMID:16602821   PMID:20554321  
PMID:21873635   PMID:22355072   PMID:22691552   PMID:24823392   PMID:25756309   PMID:26053317   PMID:26418326   PMID:28154160   PMID:30075164   PMID:30081043  


Genomics

Comparative Map Data
Npffr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391061,430,600 - 61,465,243 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1061,431,271 - 61,464,344 (+)EnsemblGRCm39 Ensembl
GRCm381061,595,295 - 61,629,464 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1061,595,492 - 61,628,565 (+)EnsemblGRCm38mm10GRCm38
MGSCv371061,058,232 - 61,089,133 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361060,991,514 - 61,021,742 (+)NCBIMGSCv36mm8
Celera1062,696,844 - 62,727,819 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.24NCBI
NPFFR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381070,247,329 - 70,284,004 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1070,247,329 - 70,284,004 (-)EnsemblGRCh38hg38GRCh38
GRCh371072,007,085 - 72,043,760 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361071,684,719 - 71,707,727 (-)NCBINCBI36Build 36hg18NCBI36
Build 341071,684,718 - 71,696,154NCBI
Celera1065,294,771 - 65,323,520 (-)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1066,007,982 - 66,036,738 (-)NCBIHuRef
CHM1_11072,296,529 - 72,325,723 (-)NCBICHM1_1
T2T-CHM13v2.01071,116,278 - 71,152,972 (-)NCBIT2T-CHM13v2.0
Npffr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82030,082,604 - 30,116,752 (+)NCBIGRCr8
mRatBN7.22029,539,795 - 29,573,951 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2029,539,795 - 29,571,196 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2030,555,746 - 30,587,142 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02029,942,024 - 29,973,412 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02030,684,511 - 30,715,898 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02031,214,950 - 31,248,710 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2031,234,493 - 31,245,955 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02032,997,426 - 33,030,516 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42028,983,735 - 28,995,194 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12028,997,534 - 29,008,994 (+)NCBI
Celera2030,966,998 - 30,998,217 (+)NCBICelera
Cytogenetic Map20q11NCBI
Npffr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543720,976,867 - 21,001,194 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543720,976,867 - 21,001,194 (+)NCBIChiLan1.0ChiLan1.0
NPFFR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2882,401,334 - 82,438,138 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11082,406,655 - 82,443,459 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01066,721,483 - 66,758,287 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11069,257,022 - 69,291,838 (-)NCBIpanpan1.1PanPan1.1panPan2
NPFFR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1421,191,403 - 21,223,715 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl421,197,733 - 21,203,099 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha421,323,904 - 21,351,213 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0421,466,975 - 21,492,765 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl421,473,411 - 21,493,131 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1421,364,430 - 21,390,200 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0421,569,576 - 21,595,343 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0421,920,758 - 21,946,551 (-)NCBIUU_Cfam_GSD_1.0
Npffr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721359,834,368 - 59,851,935 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365218,329,153 - 8,342,246 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365218,327,093 - 8,342,390 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPFFR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1473,182,892 - 73,205,829 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11473,183,585 - 73,195,804 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21479,103,900 - 79,116,127 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPFFR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1961,030,574 - 61,052,052 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl961,041,567 - 61,051,960 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604821,770,185 - 21,792,342 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npffr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247544,396,759 - 4,406,078 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247544,390,049 - 4,410,208 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Npffr1
983 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:133
Interacting mature miRNAs:141
Transcripts:ENSMUST00000020287
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102159119268091639Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
1300898Cfid_mcystic fibrosis intestinal distress (mouse)Not determined102972040363720483Mouse
10045632Heal16_mwound healing/regeneration 16 (mouse)Not determined103097449964974630Mouse
1357558Bmch4_mbone mechanical trait 4 (mouse)Not determined103157713665577284Mouse
27095920Pglq9_mpelvic girdle length QTL 9, 10 week (mouse)103377599670835830Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
4141070Ltgq1_mliver triglyceride QTL 1 (mouse)Not determined4123732675237326Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
26884421Cvht5_mcranial vault height 5, 10 week (mouse)104557609669135830Mouse
26884400Huml5_mhumerus length 5, 16 week (mouse)104627609669235830Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
4141159Phl2_mprogressive hearing loss 2 (mouse)Not determined104797449970112651Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000020287   ⟹   ENSMUSP00000020287
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1061,431,271 - 61,464,344 (+)Ensembl
GRCm38.p6 Ensembl1061,595,492 - 61,628,565 (+)Ensembl
RefSeq Acc Id: NM_001177511   ⟹   NP_001170982
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391061,431,074 - 61,465,243 (+)NCBI
GRCm381061,595,295 - 61,629,464 (+)NCBI
MGSCv371061,058,232 - 61,089,133 (+)RGD
Celera1062,696,844 - 62,727,819 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011243444   ⟹   XP_011241746
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391061,430,600 - 61,465,243 (+)NCBI
GRCm381061,613,956 - 61,629,464 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001170982 (Get FASTA)   NCBI Sequence Viewer  
  XP_011241746 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAO85090 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000020287
  ENSMUSP00000020287.6
Reference Protein Sequences
RefSeq Acc Id: NP_001170982   ⟸   NM_001177511
- UniProtKB: E9Q468 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011241746   ⟸   XM_011243444
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000020287   ⟸   ENSMUST00000020287
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9Q468-F1-model_v2 AlphaFold E9Q468 1-432 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2685082 AgrOrtholog
Ensembl Genes ENSMUSG00000020090 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020287 ENTREZGENE
  ENSMUST00000020287.8 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  NPFF_rcpt UniProtKB/TrEMBL
  NPFF_rcpt_1 UniProtKB/TrEMBL
KEGG Report mmu:237362 UniProtKB/TrEMBL
MGD MGI:2685082 ENTREZGENE
NCBI Gene 237362 ENTREZGENE
PANTHER NEUROPEPTIDE FF RECEPTOR 1 UniProtKB/TrEMBL
  NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Npffr1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  NPFFRECEPTOR UniProtKB/TrEMBL
  NPFFRECEPTR1 UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt E9Q468 ENTREZGENE, UniProtKB/TrEMBL
  Q80T60_MOUSE UniProtKB/TrEMBL