Tarm1 (T cell-interacting, activating receptor on myeloid cells 1) - Rat Genome Database

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Gene: Tarm1 (T cell-interacting, activating receptor on myeloid cells 1) Mus musculus
Analyze
Symbol: Tarm1
Name: T cell-interacting, activating receptor on myeloid cells 1
RGD ID: 1618104
MGI Page MGI
Description: Predicted to enable immunoglobulin receptor binding activity. Involved in negative regulation of CD4-positive, alpha-beta T cell proliferation and positive regulation of cytokine production involved in inflammatory response. Located in plasma membrane. Orthologous to human TARM1 (T cell-interacting, activating receptor on myeloid cells 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9930022N03Rik; ENSMUSG00000053338; Gm9904; OLT-2; OSCAR-like transcript-2 protein; T-cell-interacting, activating receptor on myeloid cells protein 1
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3973,535,015 - 3,551,159 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl73,535,016 - 3,551,140 (-)EnsemblGRCm39 Ensembl
GRCm3873,486,499 - 3,502,754 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl73,486,500 - 3,502,624 (-)EnsemblGRCm38mm10GRCm38
MGSCv3773,489,957 - 3,503,433 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera73,442,677 - 3,460,387 (-)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.04NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IDA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:14610273   PMID:16141072   PMID:16141073   PMID:21873635   PMID:26311901   PMID:33397982  


Genomics

Comparative Map Data
Tarm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3973,535,015 - 3,551,159 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl73,535,016 - 3,551,140 (-)EnsemblGRCm39 Ensembl
GRCm3873,486,499 - 3,502,754 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl73,486,500 - 3,502,624 (-)EnsemblGRCm38mm10GRCm38
MGSCv3773,489,957 - 3,503,433 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera73,442,677 - 3,460,387 (-)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.04NCBI
TARM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381954,069,895 - 54,081,365 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1954,069,895 - 54,081,365 (-)EnsemblGRCh38hg38GRCh38
GRCh371954,573,149 - 54,584,634 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361959,265,069 - 59,276,421 (-)NCBINCBI36Build 36hg18NCBI36
Celera1951,612,866 - 51,624,307 (-)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1950,888,981 - 50,900,482 (-)NCBIHuRef
CHM1_11954,574,966 - 54,586,384 (-)NCBICHM1_1
T2T-CHM13v2.01957,148,389 - 57,159,893 (-)NCBIT2T-CHM13v2.0
Tarm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8174,582,103 - 74,600,203 (+)NCBIGRCr8
mRatBN7.2165,666,742 - 65,682,402 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl165,671,902 - 65,679,626 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0164,241,742 - 64,256,646 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl164,241,865 - 64,254,564 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0163,233,198 - 63,248,022 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4163,979,894 - 63,992,593 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera163,390,776 - 63,405,679 (+)NCBICelera
Cytogenetic Map1q12NCBI
TARM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22060,074,577 - 60,087,223 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11961,996,362 - 62,009,012 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01951,002,643 - 51,014,597 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11959,846,601 - 59,857,087 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1959,846,601 - 59,857,087 (-)Ensemblpanpan1.1panPan2
LOC484314
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11103,182,052 - 103,187,416 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1103,243,657 - 103,249,266 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01103,831,921 - 103,837,531 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11103,464,747 - 103,470,357 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01103,226,403 - 103,232,012 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,945,330 - 103,950,941 (-)NCBIUU_Cfam_GSD_1.0
TARM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl656,038,524 - 56,049,764 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1656,038,524 - 56,051,487 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2653,165,322 - 53,171,328 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TARM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1646,749,522 - 46,755,192 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl646,749,580 - 46,754,799 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607326,835,838 - 26,840,960 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:113
Interacting mature miRNAs:122
Transcripts:ENSMUST00000065703
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301177Vent3_mventricular size 3 (mouse)Not determined7120511925Mouse
10054067Sle20_msystematic lupus erythematosus susceptibility 20 (mouse)Not determined7120511925Mouse
1302188Lxw6_mlupus BXSB x NZW 6 (mouse)Not determined7121698146Mouse
12904941Edlmmq6_mextensor digitorum longus muscle mass QTL 6 (mouse)7121821047Mouse
12904948Tammq5_mtibialis anterior muscle mass QTL 5 (mouse)7121821047Mouse
12904953Gmmq5_mgastrocnemius muscle mass QTL 5 (mouse)7121821047Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1302115Abhr3_mallergen-induced bronchial hyperresponsiveness 3 (mouse)Not determined7331599616637423Mouse
1301115Lrdm1_mlymphoproliferation (Fas) renal disease modifier 1 (mouse)Not determined7335204824879418Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000065703   ⟹   ENSMUSP00000069745
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl73,537,587 - 3,551,034 (-)Ensembl
GRCm38.p6 Ensembl73,489,071 - 3,502,518 (-)Ensembl
RefSeq Acc Id: ENSMUST00000203020   ⟹   ENSMUSP00000145188
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl73,535,016 - 3,551,074 (-)Ensembl
GRCm38.p6 Ensembl73,486,500 - 3,502,558 (-)Ensembl
RefSeq Acc Id: ENSMUST00000203821   ⟹   ENSMUSP00000145491
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl73,537,086 - 3,551,140 (-)Ensembl
GRCm38.p6 Ensembl73,488,570 - 3,502,624 (-)Ensembl
RefSeq Acc Id: NM_001362148   ⟹   NP_001349077
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3973,535,016 - 3,551,140 (-)NCBI
GRCm3873,486,500 - 3,502,624 (-)NCBI
Sequence:
RefSeq Acc Id: NM_177363   ⟹   NP_796337
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3973,537,585 - 3,551,140 (-)NCBI
GRCm3873,489,069 - 3,502,624 (-)NCBI
MGSCv3773,489,957 - 3,503,433 (-)RGD
Celera73,442,677 - 3,460,387 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006539980   ⟹   XP_006540043
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3973,535,015 - 3,551,159 (-)NCBI
GRCm3873,486,499 - 3,502,643 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_796337   ⟸   NM_177363
- Peptide Label: isoform 1 precursor
- UniProtKB: B6A8R8 (UniProtKB/Swiss-Prot),   A0A0R3P9C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006540043   ⟸   XM_006539980
- Peptide Label: isoform X1
- UniProtKB: A0A0R3P9C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001349077   ⟸   NM_001362148
- Peptide Label: isoform 2 precursor
- UniProtKB: A0A0N4SVP3 (UniProtKB/TrEMBL),   A0A0R3P9C5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000145491   ⟸   ENSMUST00000203821
RefSeq Acc Id: ENSMUSP00000069745   ⟸   ENSMUST00000065703
RefSeq Acc Id: ENSMUSP00000145188   ⟸   ENSMUST00000203020
Protein Domains
Ig-like   Ig-like C2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B6A8R8-F1-model_v2 AlphaFold B6A8R8 1-288 view protein structure

Promoters
RGD ID:6891608
Promoter ID:EPDNEW_M9255
Type:initiation region
Name:Tarm1_1
Description:Mus musculus T cell-interacting, activating receptor on myeloidcells 1 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3873,502,624 - 3,502,684EPDNEW
RGD ID:6840328
Promoter ID:MM_KWN:48380
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:UC009EUZ.1,   UC009EVA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3673,503,251 - 3,503,751 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2442280 AgrOrtholog
Ensembl Genes ENSMUSG00000053338 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000065703.9 UniProtKB/TrEMBL
  ENSMUST00000203020 ENTREZGENE
  ENSMUST00000203020.3 UniProtKB/TrEMBL
  ENSMUST00000203821 ENTREZGENE
  ENSMUST00000203821.3 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2442280 ENTREZGENE
NCBI Gene 245126 ENTREZGENE
PANTHER MHC CLASS I NK CELL RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-CELL-INTERACTING, ACTIVATING RECEPTOR ON MYELOID CELLS PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tarm1 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SVP3 ENTREZGENE, UniProtKB/TrEMBL
  A0A0R3P9C5 ENTREZGENE, UniProtKB/TrEMBL
  B6A8R8 ENTREZGENE, UniProtKB/Swiss-Prot