Foxr2 (forkhead box R2) - Rat Genome Database

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Gene: Foxr2 (forkhead box R2) Mus musculus
Analyze
Symbol: Foxr2
Name: forkhead box R2
RGD ID: 1617900
MGI Page MGI
Description: Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human FOXR2 (forkhead box R2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EG436240; forkhead box protein N6; forkhead box protein R2; Fox; Foxn6; RP23-180D16.2
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X151,897,577 - 151,915,857 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX151,901,782 - 151,915,857 (+)EnsemblGRCm39 Ensembl
GRCm38X153,114,581 - 153,132,861 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX153,118,786 - 153,132,861 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X149,553,331 - 149,567,404 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X148,459,504 - 148,473,577 (+)NCBIMGSCv36mm8
CeleraX136,121,698 - 136,135,767 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleoplasm  (ISO)
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15202009   PMID:16141072   PMID:16141073   PMID:18799693   PMID:21267068  
PMID:21677750   PMID:21873635   PMID:30976792  


Genomics

Comparative Map Data
Foxr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X151,897,577 - 151,915,857 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX151,901,782 - 151,915,857 (+)EnsemblGRCm39 Ensembl
GRCm38X153,114,581 - 153,132,861 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX153,118,786 - 153,132,861 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X149,553,331 - 149,567,404 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X148,459,504 - 148,473,577 (+)NCBIMGSCv36mm8
CeleraX136,121,698 - 136,135,767 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
FOXR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X55,623,400 - 55,626,192 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX55,623,400 - 55,626,192 (+)EnsemblGRCh38hg38GRCh38
GRCh37X55,649,833 - 55,652,625 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X55,666,558 - 55,668,483 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X55,532,853 - 55,534,778NCBI
CeleraX59,489,526 - 59,492,314 (+)NCBICelera
Cytogenetic MapXp11.21NCBI
HuRefX52,700,710 - 52,703,498 (+)NCBIHuRef
CHM1_1X55,639,876 - 55,642,664 (+)NCBICHM1_1
T2T-CHM13v2.0X54,916,575 - 54,919,367 (+)NCBIT2T-CHM13v2.0
Foxr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X21,618,111 - 21,651,791 (-)NCBIGRCr8
mRatBN7.2X18,242,420 - 18,276,095 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX18,244,255 - 18,245,163 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X19,142,671 - 19,243,293 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX19,144,501 - 19,145,409 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X19,904,191 - 19,918,064 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X38,395,980 - 38,396,888 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX18,516,067 - 18,622,663 (-)NCBICelera
Cytogenetic MapXq12NCBI
FOXR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X56,943,508 - 57,078,529 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X56,947,115 - 57,082,140 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X47,906,094 - 47,908,013 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X56,058,295 - 56,061,076 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX56,058,601 - 56,059,536 (+)Ensemblpanpan1.1panPan2
FOXR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X47,068,833 - 47,071,857 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX47,070,381 - 47,071,328 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX38,419,584 - 38,436,632 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X47,480,852 - 47,497,897 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX47,495,402 - 47,496,349 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X46,718,577 - 46,735,626 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X47,457,601 - 47,474,648 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X47,379,258 - 47,396,305 (+)NCBIUU_Cfam_GSD_1.0
Foxr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X39,988,820 - 39,990,116 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368191,044,654 - 1,045,598 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368191,044,648 - 1,045,598 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOXR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX48,178,487 - 48,179,434 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X48,174,318 - 48,181,106 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X54,301,567 - 54,302,819 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FOXR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X51,694,672 - 51,696,857 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX51,695,241 - 51,696,176 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660865,731,728 - 5,733,651 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Foxr2
283 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2228
Count of miRNA genes:563
Interacting mature miRNAs:734
Transcripts:ENSMUST00000096265, ENSMUST00000163801
Prediction methods:Miranda, Pita, Pita,Targetscan, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX102055848162758941Mouse
1301209Cia19_mcollagen induced arthritis 19 (mouse)Not determinedX120993165160213038Mouse
25314309Syncl5_msynaptonemal complex length 5 (mouse)X121909697152582996Mouse
10412164Cmv2_mcytomegalovirus resistance 2 (mouse)Not determinedX125685149159685269Mouse
13824981Svwq2_mseminal vesicle weight QTL 2 (mouse)X128900749153782996Mouse
1558900Bw3_mbody weight QTL 3 (mouse)Not determinedX133540040165298595Mouse
10401118Pgia39_mproteoglycan induced arthritis 39 (mouse)Not determinedX144474380169476592Mouse
1302000Pgia25_mproteoglycan induced arthritis 2 (mouse)Not determinedX144474380169476592Mouse
12738421Lfibq17_mliver fibrosis QTL 17 (mouse)X148148453164945064Mouse


Expression


Sequence


RefSeq Acc Id: ENSMUST00000096265   ⟹   ENSMUSP00000093984
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX151,901,782 - 151,915,857 (+)Ensembl
GRCm38.p6 EnsemblX153,118,786 - 153,132,861 (+)Ensembl
RefSeq Acc Id: ENSMUST00000163801   ⟹   ENSMUSP00000128452
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX151,909,893 - 151,915,857 (+)Ensembl
GRCm38.p6 EnsemblX153,126,897 - 153,132,861 (+)Ensembl
RefSeq Acc Id: NM_001034894   ⟹   NP_001030066
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X151,901,784 - 151,915,857 (+)NCBI
GRCm38X153,118,788 - 153,132,861 (+)NCBI
CeleraX136,121,698 - 136,135,767 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011247841   ⟹   XP_011246143
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X151,897,577 - 151,915,857 (+)NCBI
GRCm38X153,114,581 - 153,132,861 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017318543   ⟹   XP_017174032
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X151,898,509 - 151,915,857 (+)NCBI
GRCm38X153,116,553 - 153,132,861 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001030066 (Get FASTA)   NCBI Sequence Viewer  
  XP_011246143 (Get FASTA)   NCBI Sequence Viewer  
  XP_017174032 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI51187 (Get FASTA)   NCBI Sequence Viewer  
  BAE26209 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000093984
  ENSMUSP00000093984.4
  ENSMUSP00000128452.2
GenBank Protein Q3UM89 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001030066   ⟸   NM_001034894
- UniProtKB: A2AG72 (UniProtKB/Swiss-Prot),   B2RXE0 (UniProtKB/Swiss-Prot),   Q3UM89 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011246143   ⟸   XM_011247841
- Peptide Label: isoform X1
- UniProtKB: A2AG72 (UniProtKB/Swiss-Prot),   B2RXE0 (UniProtKB/Swiss-Prot),   Q3UM89 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017174032   ⟸   XM_017318543
- Peptide Label: isoform X1
- UniProtKB: A2AG72 (UniProtKB/Swiss-Prot),   B2RXE0 (UniProtKB/Swiss-Prot),   Q3UM89 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000128452   ⟸   ENSMUST00000163801
RefSeq Acc Id: ENSMUSP00000093984   ⟸   ENSMUST00000096265

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3UM89-F1-model_v2 AlphaFold Q3UM89 1-302 view protein structure

Promoters
RGD ID:13681672
Promoter ID:EPDNEW_M24985
Type:single initiation site
Name:Foxr2_1
Description:Mus musculus forkhead box R2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X153,118,800 - 153,118,860EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3511682 AgrOrtholog
Ensembl Genes ENSMUSG00000071665 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000096265 ENTREZGENE
  ENSMUST00000096265.10 UniProtKB/Swiss-Prot
  ENSMUST00000163801.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
InterPro Fork_head_dom UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report mmu:436240 UniProtKB/Swiss-Prot
MGD MGI:3511682 ENTREZGENE
NCBI Gene 436240 ENTREZGENE
PANTHER FORKHEAD BOX PROTEIN R1 UniProtKB/Swiss-Prot
  FORKHEAD BOX PROTEIN R2 UniProtKB/Swiss-Prot
Pfam Forkhead UniProtKB/Swiss-Prot
PhenoGen Foxr2 PhenoGen
PRINTS FORKHEAD UniProtKB/Swiss-Prot
PROSITE FORK_HEAD_3 UniProtKB/Swiss-Prot
SMART SM00339 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
UniProt A2AG72 ENTREZGENE
  B2RXE0 ENTREZGENE
  FOXR2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2AG72 UniProtKB/Swiss-Prot
  B2RXE0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-09-16 Foxr2  forkhead box R2  EG436240  predicted gene, EG436240  Symbol and/or name change 5135510 APPROVED