Obi1 (ORC ubiquitin ligase 1) - Rat Genome Database

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Gene: Obi1 (ORC ubiquitin ligase 1) Mus musculus
Analyze
Symbol: Obi1
Name: ORC ubiquitin ligase 1
RGD ID: 1616736
MGI Page MGI
Description: Predicted to enable chromatin binding activity and ubiquitin-protein transferase activity. Acts upstream of or within positive regulation of mRNA splicing, via spliceosome. Predicted to be located in chromosome. Predicted to be part of chromatin. Orthologous to human OBI1 (ORC ubiquitin ligase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2610206B13Rik; 2810449K13Rik; AI451544; MGC35679; Obl1; riken cdna 2610206b13 gene; ring finger protein 219; Rnf2; Rnf219
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914104,714,970 - 104,760,148 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14104,714,972 - 104,760,081 (-)EnsemblGRCm39 Ensembl
GRCm3814104,477,534 - 104,522,712 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14104,477,536 - 104,522,645 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714104,876,751 - 104,921,883 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614103,363,213 - 103,408,345 (-)NCBIMGSCv36mm8
Celera14103,091,780 - 103,136,907 (-)NCBICelera
Cytogenetic Map14E2.3NCBI
cM Map1454.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromatin  (ISO)
chromosome  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11812828   PMID:12160731   PMID:12466851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:14691545  
PMID:15033168   PMID:15489334   PMID:15952741   PMID:16141072   PMID:16141073   PMID:16919269   PMID:21677750   PMID:23636947   PMID:32220064   PMID:32554809   PMID:33104214  


Genomics

Comparative Map Data
Obi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914104,714,970 - 104,760,148 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14104,714,972 - 104,760,081 (-)EnsemblGRCm39 Ensembl
GRCm3814104,477,534 - 104,522,712 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14104,477,536 - 104,522,645 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714104,876,751 - 104,921,883 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614103,363,213 - 103,408,345 (-)NCBIMGSCv36mm8
Celera14103,091,780 - 103,136,907 (-)NCBICelera
Cytogenetic Map14E2.3NCBI
cM Map1454.24NCBI
OBI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381378,614,289 - 78,659,155 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1378,614,289 - 78,659,155 (-)EnsemblGRCh38hg38GRCh38
GRCh371379,188,424 - 79,233,290 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361378,086,422 - 78,131,315 (-)NCBINCBI36Build 36hg18NCBI36
Build 341378,086,430 - 78,131,315NCBI
Celera1360,086,863 - 60,131,755 (-)NCBICelera
Cytogenetic Map13q31.1NCBI
HuRef1359,888,745 - 59,933,635 (-)NCBIHuRef
CHM1_11379,156,278 - 79,201,134 (-)NCBICHM1_1
T2T-CHM13v2.01377,840,023 - 77,884,889 (-)NCBIT2T-CHM13v2.0
Obi1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81587,684,022 - 87,723,342 (-)NCBIGRCr8
mRatBN7.21581,269,413 - 81,308,734 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1581,269,416 - 81,308,734 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1585,260,403 - 85,299,151 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01586,383,456 - 86,422,210 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01583,311,067 - 83,349,817 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01588,632,089 - 88,670,325 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1588,631,794 - 88,670,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01592,127,751 - 92,165,948 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41588,548,933 - 88,588,816 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1580,396,575 - 80,435,845 (-)NCBICelera
Cytogenetic Map15q22NCBI
Obi1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540428,758,918 - 28,804,972 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540428,759,640 - 28,803,257 (+)NCBIChiLan1.0ChiLan1.0
OBI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21480,191,945 - 80,239,208 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11378,783,266 - 78,830,538 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01359,840,406 - 59,884,765 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11378,874,466 - 78,918,298 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1378,874,466 - 78,918,446 (-)Ensemblpanpan1.1panPan2
OBI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12232,006,441 - 32,047,609 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2232,007,210 - 32,047,527 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2231,803,937 - 31,845,113 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02232,327,448 - 32,368,633 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2232,327,801 - 32,368,556 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12231,989,037 - 32,030,201 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02232,026,080 - 32,067,023 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02232,098,203 - 32,139,378 (-)NCBIUU_Cfam_GSD_1.0
Obi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945127,383,335 - 127,430,516 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365112,800,425 - 2,848,628 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365112,800,466 - 2,847,896 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OBI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1150,740,916 - 50,786,774 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11150,741,893 - 50,786,824 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21155,430,773 - 55,475,967 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OBI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1357,683,989 - 57,726,851 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl357,683,746 - 57,726,750 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604613,913,551 - 13,956,671 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Obi1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475121,752,270 - 21,803,930 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475121,752,339 - 21,803,387 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Obi1
1801 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:347
Count of miRNA genes:260
Interacting mature miRNAs:296
Transcripts:ENSMUST00000022716
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
10054475Ossc3_mosteosarcoma susceptibility 3 (mouse)Not determined1470863768104863926Mouse
1300551Lprm3_mlymphoproliferation modifier 3 (mouse)Not determined1471221224105221344Mouse
1301844Pgia29_mproteoglycan induced arthritis 29 (mouse)Not determined1474352296108352384Mouse
1558819Ossc2_mosteosarcoma susceptibility 2 (mouse)Not determined1474394976108395093Mouse
14928314Manh77_mmandible shape 77 (mouse)1476767790110767790Mouse
1558823Tbbmd6_mtotal body bone mineral density 6 (mouse)Not determined1477073696111073787Mouse
4142508Tgq25_mtriglyceride QTL 25 (mouse)Not determined85134068119134068Mouse
12792981Fbmd5_mfemoral bone mineral density 5, females only (mouse)1499838217125033054Mouse

Markers in Region
AI451544  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814104,477,799 - 104,477,884UniSTSGRCm38
MGSCv3714104,877,016 - 104,877,101UniSTSGRCm37
Celera14103,092,045 - 103,092,130UniSTS
Cytogenetic Map14E2.2UniSTS
Whitehead/MRC_RH141104.54UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000022716   ⟹   ENSMUSP00000022716
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14104,714,972 - 104,760,068 (-)Ensembl
GRCm38.p6 Ensembl14104,477,536 - 104,522,632 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227640   ⟹   ENSMUSP00000154694
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14104,739,822 - 104,760,081 (-)Ensembl
GRCm38.p6 Ensembl14104,502,386 - 104,522,645 (-)Ensembl
RefSeq Acc Id: ENSMUST00000228210   ⟹   ENSMUSP00000153932
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14104,743,719 - 104,760,058 (-)Ensembl
GRCm38.p6 Ensembl14104,506,283 - 104,522,622 (-)Ensembl
RefSeq Acc Id: ENSMUST00000228448   ⟹   ENSMUSP00000154655
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14104,740,054 - 104,760,069 (-)Ensembl
GRCm38.p6 Ensembl14104,502,618 - 104,522,633 (-)Ensembl
RefSeq Acc Id: NM_026047   ⟹   NP_080323
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914104,714,970 - 104,760,102 (-)NCBI
GRCm3814104,477,534 - 104,522,666 (-)NCBI
MGSCv3714104,876,751 - 104,921,883 (-)RGD
Celera14103,091,780 - 103,136,907 (-)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011245206   ⟹   XP_011243508
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914104,739,264 - 104,760,148 (-)NCBI
GRCm3814104,501,828 - 104,522,712 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036158857   ⟹   XP_036014750
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914104,714,970 - 104,740,431 (-)NCBI
Sequence:
RefSeq Acc Id: NP_080323   ⟸   NM_026047
- UniProtKB: Q9D1Y0 (UniProtKB/Swiss-Prot),   Q9CYU1 (UniProtKB/Swiss-Prot),   Q8K2Y0 (UniProtKB/Swiss-Prot),   G3X8V5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011243508   ⟸   XM_011245206
- Peptide Label: isoform X2
- UniProtKB: A0A2I3BRT6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000153932   ⟸   ENSMUST00000228210
RefSeq Acc Id: ENSMUSP00000154694   ⟸   ENSMUST00000227640
RefSeq Acc Id: ENSMUSP00000022716   ⟸   ENSMUST00000022716
RefSeq Acc Id: ENSMUSP00000154655   ⟸   ENSMUST00000228448
RefSeq Acc Id: XP_036014750   ⟸   XM_036158857
- Peptide Label: isoform X1
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K2Y0-F1-model_v2 AlphaFold Q8K2Y0 1-722 view protein structure

Promoters
RGD ID:8683158
Promoter ID:EPDNEW_M19609
Type:initiation region
Name:Rnf219_1
Description:Mus musculus ring finger protein 219 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3814104,522,627 - 104,522,687EPDNEW
RGD ID:6824566
Promoter ID:MM_KWN:17693
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_026047,   UC007UXD.1,   UC007UXE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3614104,921,596 - 104,922,096 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919736 AgrOrtholog
Ensembl Genes ENSMUSG00000022120 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000022716 ENTREZGENE
  ENSMUST00000022716.4 UniProtKB/TrEMBL
  ENSMUST00000227640.2 UniProtKB/TrEMBL
  ENSMUST00000228210.2 UniProtKB/TrEMBL
  ENSMUST00000228448 ENTREZGENE
  ENSMUST00000228448.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro OBI1 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  RNF219_RING-HC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:72486 UniProtKB/TrEMBL
MGD MGI:1919736 ENTREZGENE
NCBI Gene 72486 ENTREZGENE
PANTHER ORC UBIQUITIN LIGASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14609 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam zf-C3HC4_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Obi1 PhenoGen
PROSITE ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2I3BPV5_MOUSE UniProtKB/TrEMBL
  A0A2I3BRT6 ENTREZGENE, UniProtKB/TrEMBL
  G3X8V5 ENTREZGENE, UniProtKB/TrEMBL
  Q8K2Y0 ENTREZGENE
  Q9CYU1 ENTREZGENE
  Q9D019_MOUSE UniProtKB/TrEMBL
  Q9D1Y0 ENTREZGENE
  RN219_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q9CYU1 UniProtKB/Swiss-Prot
  Q9D1Y0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-04-14 Obi1  ORC ubiquitin ligase 1  Obl1  ORC ubiquitin ligase 1  Symbol and/or name change 5135510 APPROVED
2020-04-07 Obl1  ORC ubiquitin ligase 1  Rnf219  ring finger protein 219  Symbol and/or name change 5135510 APPROVED