Cfap300 (cilia and flagella associated protein 300) - Rat Genome Database

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Gene: Cfap300 (cilia and flagella associated protein 300) Mus musculus
Analyze
Symbol: Cfap300
Name: cilia and flagella associated protein 300
RGD ID: 1616537
MGI Page MGI
Description: Predicted to be located in cell projection; cytoplasm; and cytoskeleton. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 38. Orthologous to human CFAP300 (cilia and flagella associated protein 300).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9230110C19Rik; cilia- and flagella-associated protein 300; hypothetical protein LOC234912; RIKEN cDNA 9230110C19 gene; uncharacterized protein C11orf70 homolog; uncharacterized protein LOC234912
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3998,021,673 - 8,042,876 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl98,021,673 - 8,042,824 (-)EnsemblGRCm39 Ensembl
GRCm3898,021,672 - 8,042,875 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl98,021,672 - 8,042,823 (-)EnsemblGRCm38mm10GRCm38
MGSCv3798,021,672 - 8,042,823 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3698,022,193 - 8,043,344 (-)NCBIMGSCv36mm8
Celera95,413,955 - 5,435,063 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12819125   PMID:14610273   PMID:16141072   PMID:16141073   PMID:16602821   PMID:21267068  
PMID:36595063   PMID:38355793  


Genomics

Comparative Map Data
Cfap300
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3998,021,673 - 8,042,876 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl98,021,673 - 8,042,824 (-)EnsemblGRCm39 Ensembl
GRCm3898,021,672 - 8,042,875 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl98,021,672 - 8,042,823 (-)EnsemblGRCm38mm10GRCm38
MGSCv3798,021,672 - 8,042,823 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3698,022,193 - 8,043,344 (-)NCBIMGSCv36mm8
Celera95,413,955 - 5,435,063 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
CFAP300
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,047,437 - 102,084,554 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,047,437 - 102,084,554 (+)EnsemblGRCh38hg38GRCh38
GRCh3711101,918,168 - 101,955,285 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,423,409 - 101,459,360 (+)NCBINCBI36Build 36hg18NCBI36
Celera1199,079,748 - 99,116,853 (+)NCBICelera
Cytogenetic Map11q22.1NCBI
HuRef1197,844,750 - 97,881,818 (+)NCBIHuRef
CHM1_111101,801,177 - 101,838,287 (+)NCBICHM1_1
T2T-CHM13v2.011102,049,520 - 102,086,624 (+)NCBIT2T-CHM13v2.0
Cfap300
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8813,465,016 - 13,483,679 (-)NCBIGRCr8
mRatBN7.285,180,180 - 5,198,840 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl85,180,675 - 5,198,807 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx89,134,759 - 9,152,057 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.087,432,428 - 7,449,704 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.085,440,897 - 5,458,480 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.086,218,391 - 6,236,438 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl86,218,393 - 6,235,967 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.086,217,030 - 6,234,756 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,863,693 - 4,881,270 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera86,738,387 - 6,755,957 (-)NCBICelera
Cytogenetic Map8q11NCBI
Cfap300
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554125,368,495 - 5,400,305 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554125,368,983 - 5,399,406 (+)NCBIChiLan1.0ChiLan1.0
CFAP300
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29102,850,602 - 102,888,109 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111103,938,151 - 103,975,681 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01196,997,736 - 97,034,422 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111100,495,365 - 100,530,644 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11100,495,360 - 100,530,638 (+)Ensemblpanpan1.1panPan2
CFAP300
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1529,511,852 - 29,532,684 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,512,182 - 29,527,849 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha529,460,110 - 29,481,957 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,565,046 - 29,586,902 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,565,570 - 29,586,866 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,621,372 - 29,643,220 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0529,478,316 - 29,500,138 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,653,163 - 29,674,987 (-)NCBIUU_Cfam_GSD_1.0
Cfap300
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494785,731,368 - 85,769,843 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365515,766,610 - 5,797,531 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365515,766,757 - 5,797,491 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CFAP300
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl932,765,880 - 32,795,297 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1932,753,274 - 32,795,303 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2936,714,818 - 36,744,705 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CFAP300
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1193,414,720 - 93,453,964 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl193,414,766 - 93,454,729 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604332,408,477 - 32,444,774 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cfap300
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624878801,132 - 830,574 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624878801,173 - 830,479 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cfap300
791 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:253
Count of miRNA genes:203
Interacting mature miRNAs:229
Transcripts:ENSMUST00000065291
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142326Tgq19_mtriglyceride QTL 19 (mouse)Not determined121060750Mouse
1300899Chol6_mcholesterol 6 (mouse)Not determined9129902913Mouse
13434920Dcollq1_mdifferential colonization level QTL 1 (mouse)9130341840Mouse
35673312Ari7_mantibody response to influenza 7, day 45, IgG3 (mouse)9780000122211296Mouse

Markers in Region
MHAa61a6.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3898,024,630 - 8,024,781UniSTSGRCm38
MGSCv3798,024,630 - 8,024,781UniSTSGRCm37
Celera95,416,913 - 5,417,064UniSTS
Cytogenetic Map9A1UniSTS
Whitehead_YAC9 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000065291   ⟹   ENSMUSP00000063450
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl98,021,673 - 8,042,824 (-)Ensembl
GRCm38.p6 Ensembl98,021,672 - 8,042,823 (-)Ensembl
RefSeq Acc Id: ENSMUST00000215478   ⟹   ENSMUSP00000149159
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl98,022,315 - 8,042,814 (-)Ensembl
GRCm38.p6 Ensembl98,022,314 - 8,042,813 (-)Ensembl
RefSeq Acc Id: NM_001358295   ⟹   NP_001345224
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3998,021,673 - 8,042,876 (-)NCBI
GRCm3898,021,672 - 8,042,875 (-)NCBI
Sequence:
RefSeq Acc Id: NM_199017   ⟹   NP_950182
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3998,021,673 - 8,042,876 (-)NCBI
GRCm3898,021,672 - 8,042,875 (-)NCBI
MGSCv3798,021,672 - 8,042,823 (-)RGD
Celera95,413,955 - 5,435,063 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_152396
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3998,021,673 - 8,042,876 (-)NCBI
GRCm3898,021,672 - 8,042,875 (-)NCBI
Sequence:
RefSeq Acc Id: NR_152397
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3998,021,673 - 8,042,876 (-)NCBI
GRCm3898,021,672 - 8,042,875 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006509861   ⟹   XP_006509924
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3998,021,919 - 8,042,873 (-)NCBI
GRCm3898,021,918 - 8,042,786 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_950182   ⟸   NM_199017
- Peptide Label: isoform 1
- UniProtKB: Q8CC70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006509924   ⟸   XM_006509861
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001345224   ⟸   NM_001358295
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000063450   ⟸   ENSMUST00000065291
RefSeq Acc Id: ENSMUSP00000149159   ⟸   ENSMUST00000215478

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CC70-F1-model_v2 AlphaFold Q8CC70 1-267 view protein structure

Promoters
RGD ID:6844004
Promoter ID:MM_KWN:56341
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000115669,   ENSMUST00000115670,   NM_199017
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3698,042,691 - 8,043,191 (-)MPROMDB
RGD ID:8668772
Promoter ID:EPDNEW_M12417
Type:initiation region
Name:9230110C19Rik_1
Description:Mus musculus RIKEN cDNA 9230110C19 gene , transcript variant4, non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3898,042,808 - 8,042,868EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3045346 AgrOrtholog
Ensembl Genes ENSMUSG00000053070 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000065291 ENTREZGENE
  ENSMUST00000065291.2 UniProtKB/Swiss-Prot
  ENSMUST00000215478.2 UniProtKB/TrEMBL
InterPro CFAP300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:234912 UniProtKB/Swiss-Prot
MGD MGI:3045346 ENTREZGENE
NCBI Gene 234912 ENTREZGENE
PANTHER CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR31078 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF4498 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cfap300 PhenoGen
UniProt A0JP49_MOUSE UniProtKB/TrEMBL
  CF300_MOUSE UniProtKB/Swiss-Prot
  Q14BZ1_MOUSE UniProtKB/TrEMBL
  Q8CC70 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-29 Cfap300  cilia and flagella associated protein 300  9230110C19Rik  RIKEN cDNA 9230110C19 gene  Symbol and/or name change 5135510 APPROVED