Tagap (T cell activation Rho GTPase activating protein) - Rat Genome Database

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Gene: Tagap (T cell activation Rho GTPase activating protein) Mus musculus
Analyze
Symbol: Tagap
Name: T cell activation Rho GTPase activating protein
RGD ID: 1615843
MGI Page MGI
Description: Predicted to enable GTPase activator activity. Acts upstream of or within defense response to virus. Orthologous to human TAGAP (T cell activation RhoGTPase activating protein).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2610315E15Rik; MGC31468; T-cell activation GTPase-activating protein 1; T-cell activation Rho GTPase-activating protein; t-cell activation Rho GTPase-activating protein-like; t-complex distorter 1A; Tcd-1; Tcd1; Tcd1a; tcs; tcs-; tcs-1; tcs1; TR; TRD
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39178,144,832 - 8,153,729 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl178,144,832 - 8,153,729 (+)EnsemblGRCm39 Ensembl
GRCm38177,926,000 - 7,934,897 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl177,926,000 - 7,934,897 (+)EnsemblGRCm38mm10GRCm38
MGSCv37178,118,865 - 8,127,762 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36177,764,194 - 7,773,071 (+)NCBIMGSCv36mm8
Celera177,485,575 - 7,494,472 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map174.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1685890   PMID:3943128   PMID:6722884   PMID:6816725   PMID:8268678   PMID:10349636   PMID:10647000   PMID:10827448   PMID:10835400   PMID:10835401   PMID:11042159   PMID:11076861  
PMID:11217851   PMID:11471064   PMID:11544199   PMID:12466851   PMID:12477932   PMID:14559236   PMID:15489334   PMID:16116428   PMID:21677750   PMID:21873635   PMID:25268627   PMID:28462950  
PMID:29017772   PMID:29895617   PMID:32203420   PMID:32312989   PMID:37744350  


Genomics

Comparative Map Data
Tagap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39178,144,832 - 8,153,729 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl178,144,832 - 8,153,729 (+)EnsemblGRCm39 Ensembl
GRCm38177,926,000 - 7,934,897 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl177,926,000 - 7,934,897 (+)EnsemblGRCm38mm10GRCm38
MGSCv37178,118,865 - 8,127,762 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36177,764,194 - 7,773,071 (+)NCBIMGSCv36mm8
Celera177,485,575 - 7,494,472 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map174.82NCBI
TAGAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386159,034,481 - 159,044,991 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6159,034,468 - 159,045,152 (-)EnsemblGRCh38hg38GRCh38
GRCh376159,455,513 - 159,466,023 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366159,376,012 - 159,386,172 (-)NCBINCBI36Build 36hg18NCBI36
Build 346159,426,437 - 159,436,593NCBI
Celera6160,103,877 - 160,114,037 (-)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6156,926,121 - 156,936,805 (-)NCBIHuRef
CHM1_16159,717,951 - 159,728,635 (-)NCBICHM1_1
T2T-CHM13v2.06160,280,073 - 160,290,583 (-)NCBIT2T-CHM13v2.0
Tagap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8149,575,750 - 49,584,747 (-)NCBIGRCr8
mRatBN7.2147,170,725 - 47,179,705 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,170,725 - 47,179,792 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx147,719,600 - 47,727,630 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0153,707,066 - 53,715,070 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0147,795,071 - 47,803,101 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,493,990 - 47,503,492 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,493,994 - 47,502,952 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0148,797,283 - 48,806,249 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,385,839 - 41,392,522 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1141,387,283 - 41,448,005 (-)NCBI
Celera142,857,885 - 42,865,915 (-)NCBICelera
Cytogenetic Map1q11NCBI
Tagap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554393,478,708 - 3,488,777 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554393,479,041 - 3,488,403 (+)NCBIChiLan1.0ChiLan1.0
TAGAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25179,138,483 - 179,150,006 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16177,043,593 - 177,060,951 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06156,923,859 - 156,934,714 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16161,938,983 - 161,949,158 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6161,938,457 - 161,949,158 (-)Ensemblpanpan1.1panPan2
TAGAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,382,688 - 48,392,977 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,383,504 - 48,392,188 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha149,225,120 - 49,235,413 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0148,567,839 - 48,578,123 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl148,567,856 - 48,577,377 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1148,443,361 - 48,453,660 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0148,314,262 - 48,324,561 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0148,873,733 - 48,884,032 (-)NCBIUU_Cfam_GSD_1.0
Tagap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946143,363,303 - 143,438,946 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648910,615,304 - 10,624,383 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648910,615,324 - 10,623,720 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAGAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl18,209,314 - 8,219,630 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.118,209,298 - 8,217,993 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2110,042,257 - 10,050,953 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TAGAP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11386,620,021 - 86,630,814 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1386,620,046 - 86,630,956 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604059,012,151 - 59,023,344 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tagap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624929631,593 - 639,482 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624929630,707 - 642,915 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tagap
143 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:276
Count of miRNA genes:221
Interacting mature miRNAs:238
Transcripts:ENSMUST00000036370
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357452Vtbt18_mvertebral trabecular bone trait 18 (mouse)Not determined17120975022Mouse
1302196Myaa1_mmodifier of Yaa 1 (mouse)Not determined17120975022Mouse
1357902Obq19_mobesity QTL 19 (mouse)Not determined17125662076Mouse
12910982Pifs2_mpeptide-induced fatal syndrome 2 (mouse)17126189355Mouse
1357743Lith3_mlithogenic gene 3 (mouse)Not determined17126194456Mouse
1301615Cfld3_mcystic fibrosis lung disease 3 (mouse)Not determined17127081639Mouse
1300613Pcyts4_mplasmacytoma susceptibility 4 (mouse)Not determined17127081639Mouse
1302100Circp2_mcircadian photosensitivity 2 (mouse)Not determined17129198453Mouse
12910527Nrq1a_mnoise-induced hearing loss resistant QTL 1a (mouse)17129198453Mouse
12910528Nrq1_mnoise-induced hearing loss resistant QTL 1 (mouse)17129198453Mouse
13524851Asrq8_macoustic startle response 8 (mouse)17131030170Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17334817537348299Mouse
1357680Idd23_minsulin dependent diabetes susceptibility 23 (mouse)Not determined17397489026401133Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
1301327Lmr7_mleishmaniasis resistance 7 (mouse)Not determined17485475227715939Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17689393640893936Mouse
4141608Phl1_mprogressive hearing loss 1 (mouse)Not determined17787584329487423Mouse

Markers in Region
RH124372  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38177,933,376 - 7,933,606UniSTSGRCm38
GRCm38176,956,301 - 6,956,531UniSTSGRCm38
MGSCv37178,126,241 - 8,126,471UniSTSGRCm37
MGSCv371740,968 - 41,198UniSTSGRCm37
MGSCv37177,160,650 - 7,160,880UniSTSGRCm37
Celera177,486,866 - 7,487,096UniSTS
Cytogenetic Map17A1UniSTS
UniSTS:237565  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38177,934,475 - 7,934,608UniSTSGRCm38
GRCm38176,955,300 - 6,955,433UniSTSGRCm38
MGSCv37178,127,340 - 8,127,473UniSTSGRCm37
MGSCv371739,966 - 40,099UniSTSGRCm37
MGSCv37177,159,649 - 7,159,782UniSTSGRCm37
Celera177,485,864 - 7,485,997UniSTS
Cytogenetic Map17A1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000036370   ⟹   ENSMUSP00000047431
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl178,144,832 - 8,153,729 (+)Ensembl
GRCm38.p6 Ensembl177,926,000 - 7,934,897 (+)Ensembl
RefSeq Acc Id: ENSMUST00000226153
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl178,145,767 - 8,145,865 (+)Ensembl
GRCm38.p6 Ensembl177,926,935 - 7,927,033 (+)Ensembl
RefSeq Acc Id: NM_145968   ⟹   NP_666080
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39178,144,832 - 8,153,729 (+)NCBI
GRCm38177,926,000 - 7,934,897 (+)ENTREZGENE
MGSCv37178,118,865 - 8,127,762 (+)RGD
Celera177,485,575 - 7,494,472 (-)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006523354   ⟹   XP_006523417
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39178,145,687 - 8,153,673 (+)NCBI
GRCm38177,926,871 - 7,934,841 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_666080 (Get FASTA)   NCBI Sequence Viewer  
  XP_006523417 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH30886 (Get FASTA)   NCBI Sequence Viewer  
  AAH39780 (Get FASTA)   NCBI Sequence Viewer  
  AAI50729 (Get FASTA)   NCBI Sequence Viewer  
  B2RWW0 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000047431
  ENSMUSP00000047431.8
GenBank Protein SPT35805 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_666080   ⟸   NM_145968
- UniProtKB: Q8K2L9 (UniProtKB/Swiss-Prot),   Q920D6 (UniProtKB/Swiss-Prot),   B2RWW0 (UniProtKB/Swiss-Prot),   A0A2X0SG59 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006523417   ⟸   XM_006523354
- Peptide Label: isoform X1
- UniProtKB: A0A2X0SG59 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000047431   ⟸   ENSMUST00000036370
Protein Domains
Rho-GAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RWW0-F1-model_v2 AlphaFold B2RWW0 1-714 view protein structure

Promoters
RGD ID:13674686
Promoter ID:EPDNEW_M21492
Type:initiation region
Name:Tagap_1
Description:Mus musculus T cell activation Rho GTPase activating protein, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38177,926,000 - 7,926,060EPDNEW
RGD ID:6828744
Promoter ID:MM_KWN:22045
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:UC008AIR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36178,118,721 - 8,119,221 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3615484 AgrOrtholog
Ensembl Genes ENSMUSG00000033450 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000036370 ENTREZGENE
  ENSMUST00000036370.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.555.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARHGAP20-like_RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:72536 UniProtKB/Swiss-Prot
MGD MGI:3615484 ENTREZGENE
NCBI Gene 72536 ENTREZGENE
PANTHER T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-CELL ACTIVATION RHO GTPASE-ACTIVATING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tagap PhenoGen
PROSITE RHOGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2X0SG59 ENTREZGENE, UniProtKB/TrEMBL
  B2RWW0 ENTREZGENE
  Q8K2L9 ENTREZGENE
  Q920D6 ENTREZGENE
  TAGAP_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q8K2L9 UniProtKB/Swiss-Prot
  Q920D6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-02-07 Tagap  T cell activation Rho GTPase activating protein  Tagap  T-cell activation Rho GTPase-activating protein  Symbol and/or name change 5135510 APPROVED